1. Immune-mediated coagulopathy associated with topical bovine thrombin: review of the pediatric literature.
- Author
-
Rodgers GM
- Subjects
- Administration, Topical, Adolescent, Animals, Autoantibodies immunology, Blood Coagulation Disorders immunology, Cattle, Child, Child, Preschool, Cross Reactions, Hemostasis, Surgical adverse effects, Hemostasis, Surgical methods, Hemostatics administration & dosage, Hemostatics immunology, Humans, Infant, Postoperative Hemorrhage immunology, Thrombin administration & dosage, Thrombin immunology, Blood Coagulation Disorders chemically induced, Hemostatics adverse effects, Postoperative Hemorrhage chemically induced, Thrombin adverse effects
- Abstract
Postoperative bleeding may occur from a number of etiologies. An uncommon cause of postoperative bleeding is immune-mediated coagulopathy resulting from reexposure to a topical hemostat containing bovine thrombin. Some patients may develop antibodies to bovine thrombin (and other bovine coagulation proteins present in the product) which cross-react with human coagulation proteins, resulting in a coagulopathy, and occasionally, in serious bleeding and death. Most of the clinical information on this coagulopathy is in the adult medical literature. This article reviews the literature on pediatric cases with this coagulopathy and summarizes clinical outcomes and effective therapies.
- Published
- 2011
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