1. Clinical characteristics and natural history of RHO-associated retinitis pigmentosa
- Author
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Gislin Dagnelie, Ralph J. Florijn, Caroline Van Cauwenbergh, Maria M. van Genderen, Alberta A H J Thiadens, Mays Talib, Nicoline E. Schalij-Delfos, Jan Wijnholds, Julie De Zaeytijd, Camiel J. F. Boon, Mary J. van Schooneveld, Caroline C W Klaver, Irina Balikova, Elfride De Baere, Marta Fiocco, Carel B. Hoyng, Magda A. Meester-Smoor, Xuan Thanh An Nguyen, Arthur A.B. Bergen, L. Ingeborgh van den Born, Jacoline B. ten Brink, Bart P. Leroy, Ophthalmology, Epidemiology, Human Genetics, ANS - Complex Trait Genetics, ARD - Amsterdam Reproduction and Development, and Netherlands Institute for Neuroscience (NIN)
- Subjects
0301 basic medicine ,Male ,Visual acuity ,genetic structures ,Visual Acuity ,Retinal Pigment Epithelium ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,chemistry.chemical_compound ,0302 clinical medicine ,Medicine and Health Sciences ,sector retinitis pigmentosa ,General Medicine ,Middle Aged ,Natural history ,Phenotype ,natural history ,Female ,medicine.symptom ,Tomography, Optical Coherence ,medicine.medical_specialty ,Long term follow up ,inherited retinal dystrophies ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Ophthalmology ,retinitis pigmentosa ,Retinitis pigmentosa ,medicine ,Electroretinography ,Humans ,In patient ,Aged ,Retrospective Studies ,Surrogate endpoint ,business.industry ,Retinal ,medicine.disease ,eye diseases ,Low vision ,030104 developmental biology ,chemistry ,rhodopsin ,030221 ophthalmology & optometry ,sense organs ,Visual Fields ,business ,Acute-Phase Proteins ,Follow-Up Studies ,Forecasting - Abstract
PURPOSE: To investigate the natural history of RHO-associated retinitis pigmentosa (RP). METHODS: A multicenter, medical chart review of 100 patients with autosomal dominant RHO-associated RP. RESULTS: Based on visual fields, time-to-event analysis revealed median ages of 52 and 79 years to reach low vision (central visual field
- Published
- 2021