1. Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
- Author
-
Stroud MJ, Banerjee I, Veevers J, and Chen J
- Subjects
- Animals, Cytoskeleton pathology, Heart Diseases pathology, Humans, Myocytes, Cardiac chemistry, Myocytes, Cardiac pathology, Nuclear Matrix pathology, Cytoskeleton chemistry, Cytoskeleton physiology, Heart Diseases physiopathology, Myocytes, Cardiac physiology, Nuclear Matrix chemistry, Nuclear Matrix physiology, Plakins chemistry, Plakins physiology
- Abstract
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of proteins within the inner and the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton. The importance of this complex has been highlighted by the discovery of mutations in genes encoding LINC complex proteins, which cause skeletal or cardiac myopathies. Herein, this review summarizes structure, function, and interactions of major components of the LINC complex, highlights how mutations in these proteins may lead to cardiac disease, and outlines future challenges in the field.
- Published
- 2014
- Full Text
- View/download PDF