25 results on '"Pilotto, Elisabetta"'
Search Results
2. Siponimod-Related Bilateral Macular Edema: A Transient and Completely Reversible Disorder.
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Miscioscia, Alessandro, Rinaldi, Francesca, Pilotto, Elisabetta, Perini, Paola, Gallo, Paolo, Avery, Robert, Golnik, Karl C., Froment, Caroline, and Wang, An-Guor
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- 2024
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3. RETINAL DYSTROPHY IN JEUNE SYNDROME: A MULTIMODAL IMAGING CHARACTERIZATION.
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Pilotto, Elisabetta FEBO, Midena, Edoardo FEBO, FARVO, Longhin, Evelyn, and Frizziero, Luisa FEBO
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Purpose: To report multimodal imaging findings in a patient affected by Jeune syndrome-associated retinal dystrophy. Methods: Observational case report. Results: An 18-year-old girl affected by Jeune syndrome was referred to our low vision unit. She presented with bilateral high myopia, reduced visual acuity, exotropia, and nystagmus. Fundus examination detected posterior myopic staphyloma and diffuse retinal dystrophy confirmed using a full-field electroretinogram as a cone-rod dystrophy. Spectral domain optical coherence tomography detected a thick anomalous hyperreflective band located beneath an irregular and disrupted external limiting membrane, showing the primary involvement of the photoreceptors outer segment with relative sparing of the retinal pigment epithelium, as confirmed by fundus autofluorescence. Conclusion: This is a case of Jeune syndrome with retinal abnormalities studied with fundus autofluorescence and optical coherence tomography. Retinal noninvasive multimodal imaging could provide significant insight in the retinal involvement of patients affected by Jeune syndrome and should have an essential role in the multidisciplinary diagnostic approach and follow-up. [ABSTRACT FROM AUTHOR]
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- 2022
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4. A new technique of needle-guided retropupillary fixation of iris-claw intraocular lens.
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Frisina, Rino, Pilotto, Elisabetta, Tozzi, Luigi, Parrozzani, Raffaele, and Midena, Edoardo
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INTRAOCULAR lenses , *OPERATIVE surgery , *IRIS (Eye) diseases , *NEEDLES & pins , *PHACOEMULSIFICATION - Abstract
The authors developed a new surgical technique of retropupillary implantation of an iris-claw intraocular lens (RP-ICIOL). RP-ICIOL is an alternative surgical option to the scleral-fixation technique for the treatment of aphakia without capsular support. Several studies have shown that RP-ICIOL is efficient and safe. However, although it is easier to perform than scleral fixation, it presents some critical issues related to the enclavation procedure. The success of the correct enclavation without excessive surgical manipulations, with subsequent pigment dispersion and without pupil distortion, is highly related to the surgical skills of the individual surgeon. The new technique proposed by the authors consists of using a guide needle to facilitate the enclavation, and to make this surgical procedure standard. The new technique was performed in 26 patients affected by aphakia without capsular support with encouraging functional and anatomical results. [ABSTRACT FROM AUTHOR]
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- 2019
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5. MORPHOFUNCTIONAL EVALUATION IN DOME-SHAPED MACULA: A MICROPERIMETRY AND OPTICAL COHERENCE TOMOGRAPHY STUDY.
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PILOTTO, ELISABETTA, GUIDOLIN, FRANCESCA, PARRAVANO, MARIACRISTINA, VIOLA, FRANCESCO, DE GERONIMO, DANIELE, CONVENTO, ENRICA, DELL'ARTI, LAURA, TABACCHI, ELENA, PARROZZANI, RAFFAELE, CAVARZERAN, FABIANO, and MIDENA, EDOARDO
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- 2018
6. RETINAL VASCULAR ABNORMALITIES IN A LARGE COHORT OF PATIENTS AFFECTED BY NEUROFIBROMATOSIS TYPE 1: A Study Using Optical Coherence Tomography Angiography.
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PARROZZANI, RAFFAELE, PILOTTO, ELISABETTA, CLEMENTI, MAURIZIO, FRIZZIERO, LUISA, LEONARDI, FRANCESCA, CONVENTO, ENRICA, MIGLIONICO, GIACOMO, PULZE, SERENA, PERRINI, PIERDAVIDE, TREVISSON, EVA, CASSINA, MATTEO, and MIDENA, EDOARDO
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- 2018
7. HYPERREFLECTIVE INTRARETINAL SPOTS IN RADIATION MACULAR EDEMA ON SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY.
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FRIZZIERO, LUISA, PARROZZANI, RAFFAELE, MIDENA, GIULIA, MIGLIONICO, GIACOMO, VUJOSEVIC, STELA, PILOTTO, ELISABETTA, and MIDENA, EDOARDO
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- 2016
8. EXTENT OF DIABETIC MACULAR EDEMA BY SCANNING LASER OPHTHALMOSCOPE IN THE RETROMODE AND ITS FUNCTIONAL CORRELATIONS.
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Vujosevic, Stela, Pucci, Porzia, Daniele, Anna Rita, Convento, Enrica, Pilotto, Elisabetta, Parrozzani, Raffaele, Kotsafti, Olympia, Cavarzeran, Fabiano, and Midena, Edoardo
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- 2014
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9. MACULAR AND PERIPAPILLARY CHOROIDAL THICKNESS IN DIABETIC PATIENTS.
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Vujosevic, Stela, Martini, Ferdinando, Cavarzeran, Fabiano, Pilotto, Elisabetta, and Midena, Edoardo
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- 2012
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10. MICROPERIMETRY AND FUNDUS AUTOFLUORESCENCE IN DIABETIC MACULAR EDEMA.
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Vujosevic, Stela, Bottega, Elisa, Casciano, Margherita, Pilotto, Elisabetta, Convento, Enrica, and Midena, Edoardo
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- 2010
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11. RETINAL FIXATION IMPAIRMENT IN DIABETIC MACULAR EDEMA.
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Vujosevic, Stela, Pilotto, Elisabetta, Bottega, Elisa, Benetti, Elisa, Cavarzeran, Fabiano, and Midena, Edoardo
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- 2008
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12. Changes in myopia, visual acuity, and psychological distress after biofeedback visual training.
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ANGI, MARIO R., CAUCCI, SABINA, PILOTTO, ELISABETTA, RACANO, ELISABETTA, RUPOLO, GIAMPIERO, SABBADIN, ELISABETTA, Angi, M R, Caucci, S, Pilotto, E, Racano, E, Rupolo, G, and Sabbadin, E
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- 1996
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13. Treating Myopia with Acoustic Biofeedback.
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Rupolo, Giampietro, Angi, Mario, Sabbadin, Elisabetta, Caucci, Sabina, Pilotto, Elisabetta, Racano, Elisabetta, and De Bertolini, Claudio
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- 1997
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14. PHOTODYNAMIC THERAPY FOR IRIS METASTASIS FROM A MEDIASTINAL CARCINOID TUMOR.
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Midena, Edoardo, Vujosevic, Stela, and Pilotto, Elisabetta
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IRIS (Eye) ,EYE diseases ,CANCER invasiveness ,CARCINOID ,PHOTOCHEMOTHERAPY ,FLUORESCENCE angiography ,OPHTHALMOLOGY ,CANCER - Abstract
The article describes a case of iris metastasis from a mediastinal carcinoid tumor that was successfully treated with photodynamic therapy (PDT) in a 36-year-old male patient. It was observed that at 2-years follow-up, bolus PDT application resulted to a complete and long-term regression of the iris tumor. It was also noted that fluorescein angiography of iris lesion showed no leakage with localized posterior synechiae, iris atrophy and lens opacity.
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- 2008
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15. RETINAL VASCULAR ABNORMALITIES RELATED TO NEUROFIBROMATOSIS TYPE 1: Natural History and Classification by Optical Coherence Tomography Angiography in 473 Patients.
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Parrozzani R, Frizziero L, Trainiti S, Calciati A, Londei D, Miglionico G, Trevisson E, Midena G, Pilotto E, and Midena E
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- Adolescent, Choroid diagnostic imaging, Female, Follow-Up Studies, Fundus Oculi, Humans, Male, Prospective Studies, Retinal Vessels diagnostic imaging, Time Factors, Vascular Malformations diagnosis, Fluorescein Angiography methods, Neurofibromatosis 1 complications, Retinal Vessels abnormalities, Tomography, Optical Coherence methods, Vascular Malformations etiology, Visual Acuity
- Abstract
Purpose: To analyze and classify neurofibromatosis Type 1 (NF1)-related retinal vascular abnormalities (RVAs), their natural history and correlation with disease severity, in a large cohort of patients., Methods: This was an observational longitudinal study with prospective enrollment. Four hundred and seventy-three patients affected by NF1 and 150 age-matched healthy subjects were consecutively enrolled. Retinal vascular abnormalities were detected by means of near-infrared reflectance and studied by optical coherence tomography angiography. The superficial vascular plexus and the deep vascular complex (DVC) were quantitatively and qualitatively analyzed., Results: We identified RVAs in 82 of 473 (17%) NF1 patients, but in none of the 150 healthy subjects. A comparison revealed that NF1 patients with RVAs showed a higher number of NF1 diagnostic criteria (4.3 ± 1.5 vs. 3.9 ±1.5, respectively; P = 0.02) than patients without RVAs. Three different RVA types were identified on optical coherence tomography angiography: macrovascular angiomatosis of the sole superficial vascular plexus; macrovascular angiomatosis of the superficial vascular plexus combined with microvascular angiomatosis of the deep vascular complex; and combined macrovascular angiomatosis of both superficial vascular plexus and deep vascular complex. The prospective analysis of optical coherence tomography angiography images showed no significant longitudinal evolution of RVAs (mean follow-up: 3.7 ± 2.8 years). A single patient developed a de novo single RVA, and two RVAs showed detectable changes during follow-up., Conclusion: In NF1 patients, RVAs are a characteristic sign that correlates with a more severe systemic disease expression, usually remaining stable during time. Optical coherence tomography angiography allows for the identification of different RVAs subtypes.
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- 2021
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16. IDENTIFICATION AND CLASSIFICATION OF MACULAR MORPHOLOGIC BIOMARKERS RELATED TO VISUAL ACUITY IN RADIATION MACULOPATHY: A Multimodal Imaging Study.
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Parrozzani R, Midena E, Trainiti S, Londei D, Miglionico G, Annunziata T, Frisina R, Pilotto E, and Frizziero L
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- Cross-Sectional Studies, Female, Fluorescein Angiography methods, Follow-Up Studies, Fovea Centralis radiation effects, Fundus Oculi, Humans, Macular Degeneration diagnosis, Macular Degeneration etiology, Male, Middle Aged, Prospective Studies, Time Factors, Tomography, Optical Coherence methods, Brachytherapy adverse effects, Fovea Centralis pathology, Macular Degeneration classification, Melanoma radiotherapy, Uveal Neoplasms radiotherapy, Visual Acuity
- Abstract
Purpose: To identify and classify, by a multimodal imaging approach, the most relevant macular morphologic biomarkers related to visual acuity in patients affected by radiation maculopathy secondary to brachytherapy., Methods: Fifty-one consecutive patients previously treated with Iodine-125 brachytherapy because of uveal melanoma were enrolled. Each patient underwent full ophthalmologic examination including best-corrected visual acuity and multimodal macular imaging analysis. Macular morphological parameters were processed by a stepwise selection analysis., Results: Three macular parameters were identified as the most relevant macular morphologic biomarkers of poor visual acuity: the vertical thickness of the thickest macular cyst (P = 0.0001), the presence of foveal inner segment/outer segment (IS/OS) layer disruption (P = 0.0054), and the presence of foveal retinal pigment epithelium atrophy (0.0884). The intergrader agreement for these morphologic biomarkers was 0.98, 0.92, and 0.92, respectively (interclass correlation coefficient)., Conclusion: The vertical thickness of the thickest macular cyst, the presence of foveal retinal pigment epithelium atrophy, and IS/OS layer disruption can be used to clinically characterize radiation maculopathy. These parameters allow for separation of the edematous component of radiation maculopathy, which is potentially treatable in early disease stages, from late onset atrophic components, which are theoretically irreversible.
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- 2020
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17. MORPHOFUNCTIONAL EVALUATION OF MACULAR-FOVEAL CAPILLARIES: A Comparative Optical Coherence Tomography Angiography and Microperimetry Study.
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Pilotto E, Leonardi F, Deganello D, Convento E, Midena E, and Frizziero L
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- Adult, Female, Fovea Centralis blood supply, Fundus Oculi, Humans, Male, Middle Aged, Retinal Diseases physiopathology, Retrospective Studies, Visual Acuity, Capillaries pathology, Fluorescein Angiography methods, Retinal Diseases diagnosis, Retinal Vessels pathology, Tomography, Optical Coherence methods, Visual Field Tests methods, Visual Fields physiology
- Abstract
Purpose: To analyze the macular function of eyes with macular-foveal capillaries (MFC), a condition characterized by the absence of the foveal avascular zone (FAZ), identified by optical coherence tomography angiography., Methods: Eight eyes with MFC at optical coherence tomography angiography and normal visual acuity were consecutively recruited. Eight eyes of healthy subjects were enrolled as healthy controls. All eyes underwent optical coherence tomography, optical coherence tomography angiography, best-correct visual acuity, low-luminance visual acuity, contrast sensitivity measurement, colour vision tests, and both mesopic and scotopic microperimetry., Results: Best-corrected visual acuity, low-luminance visual acuity, contrast sensitivity, and colour vision tests did not differ between the two groups. At mesopic microperimetry, both foveal retinal sensitivity and mean mesopic retinal sensitivity of the central 1° were statistically inferior in MFC versus control eyes (P < 0.0001 and P < 0.0001, respectively). At scotopic microperimetry, a dense foveal scotoma, normally present in control eyes, was completely lacking in MFC eyes. Scotopic foveal retinal sensitivity was statistically superior in MFC versus control eyes (P = 0.009)., Conclusion: The absence of the foveal dense scotoma in scotopic conditions underlines that the foveal rod-free zone is not present when capillaries are present in this area. An anomalous foveal distribution of photoreceptors, with both rods and cones present in this area, may be postulated in MFC eyes.
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- 2020
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18. CHANGES OF AQUEOUS HUMOR MÜLLER CELLS' BIOMARKERS IN HUMAN PATIENTS AFFECTED BY DIABETIC MACULAR EDEMA AFTER SUBTHRESHOLD MICROPULSE LASER TREATMENT.
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Midena E, Bini S, Martini F, Enrica C, Pilotto E, Micera A, Esposito G, and Vujosevic S
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- Aged, Blotting, Western, Diabetic Retinopathy diagnostic imaging, Diabetic Retinopathy surgery, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein metabolism, Humans, Laser Coagulation, Lasers, Semiconductor, Macular Edema diagnostic imaging, Macular Edema surgery, Male, Middle Aged, Potassium Channels, Inwardly Rectifying metabolism, Tomography, Optical Coherence, Vascular Endothelial Growth Factor A metabolism, Visual Acuity physiology, Aqueous Humor metabolism, Biomarkers metabolism, Diabetic Retinopathy metabolism, Ependymoglial Cells metabolism, Macular Edema metabolism
- Abstract
Purpose: To evaluate the changes in activity of biomarkers of Mu[Combining Diaeresis]ller cells (MC) in aqueous humor of patients with diabetic macular edema after subthreshold micropulse laser, over 1 year., Methods: Patients with untreated diabetic macular edema and central retinal thickness ≤ 400 μm were enrolled. Best-corrected visual acuity, full ophthalmic examination, and optical coherence tomography were performed. Subthreshold micropulse laser was applied every 3 months. Glial fibrillary acidic protein and inwardly rectifying potassium channel (Kir 4.1), MC activity markers, and vascular endothelial growth factor were quantified in the aqueous humor collected at baseline and at 1, 3, and 12 months after laser. Changes in the macular thickness and inner nuclear layer thickness, where MC bodies are located, were measured., Results: Ten eyes of 10 patients were included. Best-corrected visual acuity improved at 3 months (P = 0.047) and remained stable. Inner nuclear layer thickness significantly reduced at 12 months (P = 0.012). Glial fibrillary acidic protein, Kir 4.1, and vascular endothelial growth factor decreased at 1 and/or 3 and/or 12 months compared with baseline (P < 0.05)., Conclusion: Subthreshold micropulse laser improves visual function in diabetic macular edema. Kir 4.1 and glial fibrillary acidic protein decrease and inner nuclear layer thickness reduction demonstrate that subthreshold micropulse laser may restore MC function. Subthreshold micropulse laser also reduces vascular endothelial growth factor concentration. The effect of subthreshold micropulse laser in diabetic macular edema may in part be due to changes of MC metabolic activity.
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- 2020
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19. MORPHOFUNCTIONAL EVALUATION IN DOME-SHAPED MACULA: A MICROPERIMETRY AND OPTICAL COHERENCE TOMOGRAPHY STUDY.
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Pilotto E, Guidolin F, Parravano M, Viola F, De Geronimo D, Convento E, dellʼArti L, Tabacchi E, Parrozzani R, Cavarzeran F, and Midena E
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- Adult, Aged, Aged, 80 and over, Choroid pathology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Subretinal Fluid physiology, Tomography, Optical Coherence methods, Visual Acuity physiology, Visual Fields physiology, Young Adult, Macula Lutea abnormalities, Macula Lutea physiopathology
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Purpose: To investigate retinal sensitivity (Se) in dome-shaped macula (DSM) using microperimetry and to correlate functional findings to specific spectral domain optical coherence tomography features., Methods: Patients affected by DSM in at least 1 eye were consecutively enrolled in a prospective, cross-sectional study. All studied eyes performed best-corrected visual acuity measurement, microperimetry to assess Se and optical coherence tomography to investigate DSM pattern and to measure bulge height and retinal and choroidal thicknesses., Results: Fifty-three eyes of 29 patients were studied. Dome-shaped macula was vertically oriented (V-DSM) in 23 (43.4%), symmetric (S-DSM) in 17 (32.1%), and horizontally oriented (H-DSM) in 13 eyes (24.5%). Foveal subretinal fluid was present in 29/53 (54.7%) cases; it correlated to the bulge height (P < 0.0001) and determined a reduction of Se (P < 0.0001) not of best-corrected visual acuity (P = 0.7105). Mean Se was 13.9 ± 3.2 dB. Microperimetry parameters did not differ among the different DSM patterns. However, Se was significantly impaired if foveal subretinal fluid was present in V-DSM and in S-DSM, but not in H-DSM (V-DSM: P < 0.0001; S-DSM: P = 0.0252; H-DSM: P = 0.5723). In H-DSM, inferior choroidal thickness was thicker in cases with foveal subretinal fluid compared with those without it (P = 0.0363)., Conclusion: In DSM, Se evaluation better reflects the central functional impairment than best-corrected visual acuity, particularly when some optical coherence tomography features, such as foveal subretinal fluid and higher bulge height, are present.
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- 2018
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20. RETINAL VASCULAR ABNORMALITIES IN A LARGE COHORT OF PATIENTS AFFECTED BY NEUROFIBROMATOSIS TYPE 1: A Study Using Optical Coherence Tomography Angiography.
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Parrozzani R, Pilotto E, Clementi M, Frizziero L, Leonardi F, Convento E, Miglionico G, Pulze S, Perrini P, Trevisson E, Cassina M, and Midena E
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- Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Female, Fluorescein Angiography, Humans, Male, Microscopy, Confocal, Neurofibromatosis 1 diagnosis, Ophthalmoscopy, Prevalence, Prospective Studies, Retinal Diseases epidemiology, Tomography, Optical Coherence methods, Young Adult, Neurofibromatosis 1 pathology, Retinal Diseases pathology, Retinal Vessels pathology
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Purpose: To evaluate the prevalence, the vascular features, and the clinical diagnostic implication of retinal vascular abnormalities (RVAs) associated with neurofibromatosis Type 1 (NF1) in a large cohort of patients., Methods: Two hundred and ninety-four patients affected by NF1 were consecutively enrolled. The presence of RVAs was detected by means of infrared confocal scanning laser ophthalmoscopy images. Three hundred age- and race-matched healthy subjects were enrolled as a healthy control group. Fluorescein angiography, indocyanine green angiography, and optical coherence tomography angiography were also performed in patients with RVAs., Results: Retinal vascular abnormalities were detected in 18 patients with NF1 (6.1%) and in none of the healthy subjects. Retinal vascular abnormalities appeared in all cases as well-defined, small, tortuous retinal vessels with a spiral aspect, originating from small tributaries of retinal veins. The presence of RVAs did not correlate with the presence of other specific ocular or systemic NF1 features (P > 0.05). On optical coherence tomography angiography, RVAs appeared as an isolated tortuous vessel of the superficial vascular plexus in all cases, associated with localized anomalous crowded and congested capillary network of the deep vascular plexus in 75% of cases., Conclusion: Retinal vascular abnormalities are present in a limited proportion of patients affected by NF1 and can be considered an additional distinctive sign of the disease.
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- 2018
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21. HYPERREFLECTIVE INTRARETINAL SPOTS IN RADIATION MACULAR EDEMA ON SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY.
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Frizziero L, Parrozzani R, Midena G, Miglionico G, Vujosevic S, Pilotto E, and Midena E
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- Adult, Aged, Female, Humans, Iodine Radioisotopes adverse effects, Macular Edema etiology, Male, Melanoma radiotherapy, Middle Aged, Radiation Injuries etiology, Retina diagnostic imaging, Uveal Neoplasms radiotherapy, Visual Acuity, Brachytherapy adverse effects, Macular Edema diagnostic imaging, Radiation Injuries diagnostic imaging, Retina radiation effects, Tomography, Optical Coherence
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Purpose: To better pathophysiologically characterize macular edema secondary to eye irradiation, analyzing the presence of optical coherence tomography (OCT) hyperreflective spots., Methods: Twenty-five consecutive eyes affected by radiation maculopathy, secondary to irradiation for a primary uveal melanoma, without macular involvement in the irradiation field, were consecutively enrolled. All subjects underwent full ophthalmologic examination, including fluorescein angiography, color fundus photography, and spectral domain OCT, even in en face modality. Optical coherence tomography central subfield thickness was stratified into the following 3 categories: <400 μm, 400 to 600 μm, and >600 μm. Spectral domain OCT images were analyzed to measure and localize hyperreflective spots by two independent masked graders., Results: Hyperreflective spots were documented in all eyes (100%). Hyperreflective spots significantly increased in number according to OCT central subfield thickness (<400 μm, 400-600 μm, >600 μm, P < 0.05). The intergrader agreement was at least substantial for all measurements (intraclass correlation coefficient: 0.80)., Conclusion: Spectral domain OCT documents discrete intraretinal reflectivity changes (hyperreflective spots) in all (studied) eyes affected by radiation maculopathy. Hyperreflective spots increase in number with increasing central subfield thickness and could be considered as a new clinical biomarker of intraretinal inflammation in patients affected by macular edema secondary to irradiation for uveal melanoma.
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- 2016
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22. Extent of diabetic macular edema by scanning laser ophthalmoscope in the retromode and its functional correlations.
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Vujosevic S, Pucci P, Daniele AR, Convento E, Pilotto E, Parrozzani R, Kotsafti O, Cavarzeran F, and Midena E
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- Adult, Aged, Diabetic Retinopathy physiopathology, Female, Fluorescein Angiography, Humans, Macular Edema physiopathology, Male, Middle Aged, Tomography, Optical Coherence, Visual Acuity physiology, Visual Field Tests, Visual Fields physiology, Diabetic Retinopathy diagnosis, Macular Edema diagnosis, Ophthalmoscopy methods
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Background: To determine whether scanning laser ophthalmoscope in the retromode (RM-SLO) is useful to evaluate the extent of diabetic macular edema (DME) and its functional characteristics., Methods: Comparative case series of 37 eyes (27 patients with diabetes). Inclusion criteria were: center involving DME determined by optical coherence tomography; RM-SLO, optical coherence tomography, fluorescein angiography (FA), and microperimetry performed on the same day; no significant media opacities. Two masked retinal specialists independently graded all images. The full extent of DME areas and two grades (small and large) DME areas were separately evaluated. The relationship between the DME extent obtained by RM-SLO and FA was assessed by Pearson correlation coefficient, intraclass correlation coefficient, and Bland-Altman plot. T-test was used to compare DME extent to central retinal thickness and macular sensitivity., Results: The values of RM-SLO from the right and left prospective were highly correlated in the evaluation of the extent of DME (rho = 0.99, P < 0.0001). Mean DME area on RM-SLO was 5.7 + 5.6 mm (range, 0.3-18.2 mm); mean DME area on FA was 6.4 + 5.9 mm (range, 0.3-19.7 mm). The correlation between RM-SLO and FA in the evaluation of DME extent was highly significant (rho = 0.97, P < 0.0001), even when DME extent was divided in 2 major areas (intraclass correlation coefficient >0.8, P < 0.0001). The correlation between retinal sensitivity and DME area (RM-SLO) was significant (rho = -0.61, P = 0.0003)., Conclusion: The extent has become an important parameter for monitoring DME, with or without treatment. The extent of DME well correlates with functional data, mainly retinal sensitivity. Retromode SLO can be reliably and easily used in the evaluation of DME extent, avoiding the use of invasive FA.
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- 2014
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23. Macular and peripapillary choroidal thickness in diabetic patients.
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Vujosevic S, Martini F, Cavarzeran F, Pilotto E, and Midena E
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- Blood Glucose metabolism, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 complications, Diabetic Retinopathy blood, Diabetic Retinopathy classification, Female, Fluorescein Angiography, Glycated Hemoglobin metabolism, Humans, Male, Middle Aged, Optic Disk, Organ Size, Retina, Severity of Illness Index, Tomography, Optical Coherence, Visual Acuity physiology, Choroid pathology, Diabetic Retinopathy complications
- Abstract
Purpose: To investigate macular and peripapillary choroidal thickness (CT) in diabetic patients with and without diabetic retinopathy (DR)., Methods: One hundred and fifty subjects were enrolled: 102 diabetic patients (102 eyes) and 48 normals, as controls. Exclusion criteria were previously treated DR, refractive error higher than ± 3 diopters, and treated or untreated glaucoma. All patients underwent full ophthalmic examination, stereoscopic color fundus photography, and spectral domain optical coherence tomography (RS-3000; Nidek). Spectral domain optical coherence tomography examination consisted of linear scans, 6 mm in length, centered onto the fovea, and circle scan positioned around the optic disk (3.46 mm in diameter). Choroidal thickness was measured manually at the fovea and at 1, 2, and 3 mm distance along all scans in the macula. Peripapillary CT was measured at eight points along the circle scan. All measurements were performed independently by 2 masked graders., Results: Mean age was not significantly different between patients with diabetes and controls. In the macular area, CT was significantly lower in the nasal quadrant versus all other quadrants (P < 0.0001), in both groups. In the peripapillary area, CT was significantly lower in the inferior quadrant versus all other quadrants (P < 0.05), in both groups. Mean macular and peripapillary CT progressively and significantly decreased with increasing level of DR (nonproliferative and proliferative DR vs. controls, P < 0.05). No significant CT difference was found between controls and diabetic eyes without detectable DR. Diabetic macular edema did not influence CT. Interobserver coefficient of repeatability was 28.8 (95% confidence interval, 24.8-32.8) for foveal measurements and 13.0 (95% confidence interval, 11.2-14.8) for peripapillary measurements. Pearson correlation coefficient was 0.99, and P <0.0001 for all measurements., Conclusion: Choroidal thickness is reduced in diabetic eyes and parallels appearance and evolution of DR. Spectral domain optical coherence tomography clearly confirms in vivo previously reported histopathologic observations. The role of choroid in the pathophysiology of DR needs to be adequately investigated.
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- 2012
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24. Microperimetry and fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagulation.
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Vujosevic S, Bottega E, Casciano M, Pilotto E, Convento E, and Midena E
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- Adult, Aged, Aged, 80 and over, Diabetic Retinopathy physiopathology, Female, Fluorescence, Fundus Oculi, Humans, Macular Edema physiopathology, Male, Middle Aged, Prospective Studies, Retina physiopathology, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity physiology, Visual Field Tests, Diabetic Retinopathy surgery, Fluorescein Angiography, Laser Coagulation methods, Lasers, Semiconductor therapeutic use, Macular Edema surgery, Visual Fields physiology
- Abstract
Purpose: The purpose of this study was to evaluate and compare microperimetry and fundus autofluorescence (FAF) after subthreshold micropulse diode laser versus modified Early Treatment Diabetic Retinopathy Study photocoagulation for clinically significant diabetic macular edema., Methods: A prospective randomized clinical trial including 62 eyes (50 patients) with untreated, center-involving, clinically significant diabetic macular edema was performed. All patients underwent best-corrected visual acuity determination (logarithm of the minimum angle of resolution), slit-lamp biomicroscopy, FAF, optical coherence tomography, microperimetry (macular sensitivity), and fluorescein angiography before and after treatment. Best-corrected visual acuity, optical coherence tomography, microperimetry, and FAF were repeated at 1-, 3-, 6-, 9-, and 12-month follow-up examinations. Fluorescein angiography was performed at baseline and at 6 and 12 months., Results: Before treatment, demographic and macular parameters were not different between the two treatment groups. At 12 months, best-corrected visual acuity remained stable in both groups (P = 0.41 and P = 0.82), mean central retinal thickness decreased in both groups (P = 0.0002 and P < 0.0001), and mean central 4 degrees and 12 degrees retinal sensitivity increased in the micropulse diode laser group (P = 0.02 and P = 0.0075) and decreased in the Early Treatment Diabetic Retinopathy Study group (P = 0.2 and P = 0.0026). There was no significant difference in either best-corrected visual acuity or central retinal thickness between the 2 treatment groups (P = 0.48 and P = 0.29), whereas there was a significant difference in 4 degrees and 12 degrees retinal sensitivity (P = 0.04 and P < 0.0001). Fundus autofluorescence never changed in the micropulse diode laser group even after retreatment. In the Early Treatment Diabetic Retinopathy Study group, FAF increased up to 9 months and decreased in 6 eyes (20%) at 12 months., Discussion: Micropulse diode laser seems to be as effective as modified Early Treatment Diabetic Retinopathy Study laser photocoagulation in the treatment of clinically significant diabetic macular edema. Micropulse diode laser treatment does not determine any change on FAF showing (at least) nonclinically visible damage of the retinal pigment epithelium. Microperimetry data encourage the use of a new, less aggressive laser therapeutic approach in the treatment of clinically significant diabetic macular edema.
- Published
- 2010
- Full Text
- View/download PDF
25. Retinal fixation impairment in diabetic macular edema.
- Author
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Vujosevic S, Pilotto E, Bottega E, Benetti E, Cavarzeran F, and Midena E
- Subjects
- Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 complications, Female, Fluorescein Angiography, Glycated Hemoglobin analysis, Humans, Male, Middle Aged, Prospective Studies, Tomography, Optical Coherence, Visual Acuity physiology, Visual Field Tests, Visual Fields physiology, Diabetic Retinopathy physiopathology, Fixation, Ocular physiology, Macular Edema physiopathology, Retina physiology
- Abstract
Purpose: To evaluate the characteristics of retinal fixation in patients with diabetic macular edema using microperimetry., Methods: One hundred seventy nine eyes (98 patients) with untreated diabetic macular edema underwent best corrected visual acuity determination (Early Treatment Diabetic Retinopathy Study charts), digital color stereoscopic fundus photos, fluorescein angiography and Optical Coherence Tomography assessment of macula. Fixation and retinal thresholds were determined with an automatic microperimeter., Results: Best corrected visual acuity (approximate Snellen equivalent) was: 20/25 or better in 90 (52%) eyes, 20/50 to 20/32 in 39 (22.5%) eyes, 20/200 to 20/62.5 in 35 (20.2%) eyes and inferior to 20/200 in 9 (5.2%) eyes. Fixation was central in 128 (71.51%), poor central in 26 (14.53%) and predominantly eccentric in 25 (13.97%) eyes; stable in 133 (74.3%), relatively unstable in 42 (23.46%) and unstable in 4 (2.23%) eyes. Both fixation location and stability were not significantly influenced by edema characteristics (diffuse, focal, cystoid, spongelike, with or without subfoveal neuroretinal detachment), (P > 0.05), whereas they were significantly influenced by the presence of subfoveal hard exudates, (P = 0.004 and P = 0.0046, respectively). Site and stability of fixation were significantly associated, (P < 0.0001). Retinal pseudofovea would have been covered by laser photocoagulation in 24 (47%) eyes with poorly central and predominantly eccentric fixation and in 29 (63%) eyes with relatively unstable and unstable fixation., Conclusion: Microperimetry shows that fixation location and stability in patients with diabetic macular edema are independent of edema characteristics, except when subfoveal hard exudates are present. Location of pseudofovea may influence treatment strategy.
- Published
- 2008
- Full Text
- View/download PDF
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