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Start Over Author "Petry, Andreas" Publisher lippincott williams & wilkins
1 results on '"Petry, Andreas"'

1. Phosphodiesterase 2 Mediates Redox-Sensitive Endothelial Cell Proliferation and Angiogenesis by Thrombin via Rac1 and NADPH Oxidase 2.

Author

Diebold, Isabel, Djordjevic, Talija, Petry, Andreas, Hatzelmann, Armin, Tenor, Hermann, Hess, John, and Görlach, Agnes

Subjects
CYCLIC nucleotide phosphodiesterases, THROMBIN, BLOOD coagulation factors, CELL proliferation, OXIDASES, NEOVASCULARIZATION
Abstract

The article examines whether cyclic nucleotide phosphodiesterases 2 (PDE2) will link to reactive oxygen species (ROS) generation and proliferative responses in human umbilical vein endothelial cells in response to thrombin. It was found that overexpression of PDE2 increases ROS generation and enhance proliferation. Inhibition of PDE2 prevents thrombin-induced proliferation and capillary formation. PDE2 also promotes activation of NADPH oxidase-dependent ROS production and angiogenesis.

Published
2009
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