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Your search keyword '"Miele, Luca"' showing total 12 results
Start Over Author "Miele, Luca" Publisher lippincott williams & wilkins
12 results on '"Miele, Luca"'

1. Letter to the Editor: Suboptimal performance of CAR-OLT score to predict 1-year risk of cardiovascular events after liver transplantation.

Author

Biolato, Marco, Saracco, Margherita, Petti, Anna, Lavezzo, Bruna, Avolio, Alfonso Wolfango, Martini, Silvia, Grieco, Antonio, Romagnoli, Renato, Gasbarrini, Antonio, Agnes, Salvatore, Pompili, Maurizio, Miele, Luca, Marrone, Giuseppe, Liguori, Antonio, Pedicino, Daniela, Risso, Alessandra, Tomasello, Lidia, and Galati, Francesco

Published
2023
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2. Presence of Serum Antinuclear Antibodies Does Not Impact Long-Term Outcomes in Nonalcoholic Fatty Liver Disease.

Author

Younes, Ramy, Govaere, Olivier, Petta, Salvatore, Miele, Luca, Tiniakos, Dina, Burt, Alastair, David, Ezio, Vecchio, Fabio M., Maggioni, Marco, Cabibi, Daniela, Fracanzani, Anna L., Rosso, Chiara, Blanco, Maria J. Garcia, Armandi, Angelo, Caviglia, Gian Paolo, Zaki, Marco Y. W., Liguori, Antonio, Francione, Paolo, Pennisi, Grazia, and Grieco, Antonio

Published
2020
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3. Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease.

Author

Dongiovanni, Paola, Meroni, Marica, Mancina, Rosellina M., Baselli, Guido, Rametta, Raffaela, Pelusi, Serena, Männistö, Ville, Fracanzani, Anna L., Badiali, Sara, Miele, Luca, Grimaudo, Stefania, Petta, Salvatore, Bugianesi, Elisabetta, Soardo, Giorgio, Fargion, Silvia, Pihlajamäki, Jussi, Romeo, Stefano, and Valenti, Luca

Subjects
PHOSPHOPROTEIN phosphatases, HEPATIC fibrosis, FATTY liver
Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver damage and has a strong genetic component. The rs4841132 G>A variant, modulating the expression of protein phosphatase 1 regulatory subunit 3B (PPP1R3B), which is involved in glycogen synthesis, has been reported to reduce the risk of NAFLD but at the same time may favor liver disease by facilitating glycogen accumulation. The aim of this study was to assess the impact of rs4841132 on development of histologic steatosis and fibrosis in 1,388 European individuals in a liver biopsy cohort, on NAFLD hepatocellular carcinoma in a cross‐sectional Italian cohort (n = 132 cases), and on liver disease at the population level in the United Kingdom Biobank cohort. We investigated the underlying mechanism by examining the impact of the variant on gene expression profiles. In the liver biopsy cohort, the rs4841132 minor A allele was associated with protection against steatosis (odds ratio [OR], 0.63; 95% confidence interval [CI], 0.42‐0.95; P = 0.03) and clinically significant fibrosis (OR, 0.35; 95% CI, 0.14‐0.87; P = 0.02) and with reduced circulating cholesterol (P = 0.02). This translated into protection against hepatocellular carcinoma development (OR, 0.22; 95% CI, 0.07‐0.70; P = 0.01). At the population level, the rs4841132 variation was not associated with nonalcoholic or nonviral diseases of the liver but was associated with lower cholesterol (P = 1.7 × 10–8). In individuals with obesity, the A allele protecting against steatosis was associated with increased PPP1R3B messenger RNA expression and activation of lipid oxidation and with down‐regulation of pathways related to lipid metabolism, inflammation, and cell cycle. Conclusion: The rs4841132 A allele is associated with protection against hepatic steatosis and fibrosis in individuals at high risk of NAFLD but not in the general population and against dyslipidemia. The mechanism may be related to modulation of PPP1R3B expression and hepatic lipid metabolism. (Hepatology Communications 2018;2:666‐675) [ABSTRACT FROM AUTHOR]

Published
2018
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4. Availability of a Web and Smartphone Application to Stratify the Risk of of Early Allograft Failure Requiring Liver Retransplantation.

Author

Avolio, Alfonso W., Contegiacomo, Andrea, Agnes, Salvatore, Marrone, Giuseppe, Moschetta, Giovanni, Miele, Luca, and Melcher, Marc L.

Subjects
HOMOGRAFTS, LIVER failure, MOBILE apps, WEB-based user interfaces, KIDNEY failure, LIVER transplantation
Abstract

GLO:L3KC/01jan22:hep41754-toc-0001.jpg PHOTO (COLOR): . gl TO THE EDITOR: We read with interest the study that associated increased hospital costs with early allograft dysfunction (EAD) after liver transplantation (LT). SP ( sp 1 SP ) sp We believe the dichotomic definition of EAD adopted SP ( sp 2 SP ) sp does not allow a granular stratification of both failure risk and costs. The EASE score facilitates the prediction and mitigation of the overall postoperative risk by disentangling EAD cases in a granular way and could be tested in the cohort SP ( sp 1 SP ) sp for assessing LT and retransplant costs. [Extracted from the article]

Published
2022
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6. Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.

Author

Eslam, Mohammed, Mangia, Alessandra, Berg, Thomas, Chan, Henry Lik Yuen, Irving, William L., Dore, Gregory J., Abate, Maria Lorena, Bugianesi, Elisabetta, Adams, Leon A., Najim, Mustafa A.M., Miele, Luca, Weltman, Martin, Mollison, Lindsay, Cheng, Wendy, Riordan, Stephen, Fischer, Janett, Romero‐Gomez, Manuel, Spengler, Ulrich, Nattermann, Jacob, and Rahme, Antony

Published
2016
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7. Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.

Author

Bechmann, Lars P., Gastaldelli, Amalia, Vetter, Diana, Patman, Gillian L., Pascoe, Laura, Hannivoort, Rebekka A., Lee, Ursula E., Fiel, Isabel, Muñoz, Ursula, Ciociaro, Demetrio, Lee, Young-Min, Buzzigoli, Emma, Miele, Luca, Hui, Kei Y., Bugianesi, Elisabetta, Burt, Alastair D., Day, Christopher P., Mari, Andrea, Agius, Loranne, and Walker, Mark

Published
2012
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