1. Lysyl Oxidase Inhibition Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice.
- Author
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Michihiro Okuyama, Weihua Jiang, Javidan, Aida, Zheying Chen, Jeff, Howatt, Deborah A., Lihua Yang, Hamaguchi, Mika, Takumi Yasugi, Jun Aono, Vazquez-Padron, Roberto Irenardo, Subramanian, Venkateswaran, Okuyama, Michihiro, Jiang, Weihua, Chen, Jeff Zheying, Yang, Lihua, Yasugi, Takumi, and Aono, Jun
- Subjects
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LYSYL oxidase , *ABDOMINAL aortic aneurysms , *SEXUAL dimorphism , *MICE , *ANGIOTENSIN II , *PROTEIN metabolism , *HUMAN reproduction , *PROTEINS , *RESEARCH , *ANIMAL experimentation , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *OXIDOREDUCTASES , *ENZYME inhibitors , *PHARMACODYNAMICS , *CHEMICAL inhibitors - Abstract
Consistent with LOX protein abundance, LOX activity in female aortic tissue was 2.5-fold significantly higher than in male aortic tissue, and AngII infusion had no influence on LOX activity in either sex (Figure C). H though L, LOX inhibition accelerated AngII-induced AAA formation and incidence in female mice as similar to male mice (n=5-25, *P<0.05 AngII+BAPN vs saline/BAPN/AngII; 2-way ANOVA followed by Holm-Sidak post hoc test). [Extracted from the article]
- Published
- 2020
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