26 results on '"McFadden, EP"'
Search Results
2. High-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography.
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Mollet NR, Cademartiri F, van Mieghem CA, Runza G, McFadden EP, Baks T, Serruys PW, Krestin GP, de Feyter PJ, Mollet, Nico R, Cademartiri, Filippo, van Mieghem, Carlos A G, Runza, Giuseppe, McFadden, Eugène P, Baks, Timo, Serruys, Patrick W, Krestin, Gabriel P, and de Feyter, Pim J
- Published
- 2005
3. Short- and long-term clinical outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: insights from the Rapamycin-Eluting and Taxus Stent Evaluated At Rotterdam Cardiology Hospital registries (RESEARCH and T-SEARCH).
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Valgimigli M, van Mieghem CAG, Ong ATL, Aoki J, Rodriguez Granillo GA, McFadden EP, Kappetein AP, de Feyter PJ, Smits PC, Regar E, Van der Giessen WJ, Sianos G, de Jaegere P, Van Domburg RT, Serruys PW, Valgimigli, Marco, van Mieghem, Carlos A G, Ong, Andrew T L, Aoki, Jiro, and Granillo, Gaston A Rodriguez
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- 2005
4. Incidence of high-strain patterns in human coronary arteries: assessment with three-dimensional intravascular palpography and correlation with clinical presentation.
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Schaar JA, Regar E, Mastik F, McFadden EP, Saia F, Disco C, de Korte CL, de Feyter PJ, van der Steen AFW, Serruys PW, Schaar, Johannes A, Regar, Evelyn, Mastik, Frits, McFadden, Eugene P, Saia, Francesco, Disco, Clemens, de Korte, Chris L, de Feyter, Pim J, van der Steen, Antonius F W, and Serruys, Patrick W
- Published
- 2004
5. Impact of periprocedural biomarker elevation on mortality in stable angina pectoris patients undergoing elective coronary intervention: a systematic review and meta-analysis including 24 666 patients.
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Soud M, Hideo-Kajita A, Ho G, Yacob O, Alahdab F, King F, Waksman R, McFadden EP, and Garcia-Garcia HM
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- Angina, Stable metabolism, Cause of Death, Coronary Artery Disease metabolism, Humans, Mortality, Myocardial Infarction metabolism, Perioperative Period, Postoperative Complications metabolism, Angina, Stable surgery, Cardiovascular Diseases mortality, Coronary Artery Disease surgery, Elective Surgical Procedures, Myocardial Infarction epidemiology, Percutaneous Coronary Intervention, Postoperative Complications epidemiology
- Abstract
Background: Uncertainty remains regarding the exact prognostic impact of biomarker elevation following percutaneous coronary intervention in patients with stable angina pectoris and the subsequent risk of death. We sought, therefore, to evaluate the effect of periprocedural myocardial infarction on the subsequent mortality risk following percutaneous coronary intervention in patients with stable angina pectoris and normal preprocedural cardiac biomarkers level., Methods: After a systematic literature search was done in PubMed and EMBASE, we performed a meta-analysis of studies with post-procedural cardiac biomarkers data. All-cause mortality and cardiac death were evaluated in subjects with stable angina pectoris who underwent an elective coronary intervention., Results: Fourteen studies with 24 666 patients were included. The mean age was 64.2 years ± 9.8 with about 3-quarters (74.9%) of these patients being men. The mean duration of follow-up was 18.1 months ± 14.3. Periprocedural myocardial infarction, based on study-specific biomarker criteria, occurred in 14.3% of the patients. Periprocedural myocardial infarction conferred a statistically significant increase in the risk of all-cause mortality (odds ratio, 1.62; 95% confidence interval, 1.30-2.01; P < 0.0001; I = 0%); where reported separately, cardiac death was also significantly increase (odds ratio, 2.77; 95% confidence interval, 1.60-4.80; P = 0.0003; I = 0%)., Conclusion: The occurrence of periprocedural myocardial infarction after an elective percutaneous coronary intervention in patients with stable angina pectoris is associated with a statistically significant increase in subsequent all-cause mortality and cardiac mortality.
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- 2020
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6. Standardized End Point Definitions for Coronary Intervention Trials: The Academic Research Consortium-2 Consensus Document.
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Garcia-Garcia HM, McFadden EP, Farb A, Mehran R, Stone GW, Spertus J, Onuma Y, Morel MA, van Es GA, Zuckerman B, Fearon WF, Taggart D, Kappetein AP, Krucoff MW, Vranckx P, Windecker S, Cutlip D, and Serruys PW
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- Aortic Valve Stenosis, Clinical Trials as Topic, Consensus, Humans, Bioprosthesis standards, Blood Vessel Prosthesis standards, Blood Vessel Prosthesis Implantation standards, Coronary Vessels surgery, Prosthesis Design standards, Stents standards
- Abstract
The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bioresorbable vascular scaffolds. In addition, recommendations for the incorporation of patient-related outcomes in clinical trials are proposed. Academic Research Consortium-2 is a collaborative effort between academic research organizations in the United States and Europe, device manufacturers, and European, US, and Asian regulatory bodies. Several in-person meetings were held to discuss the changes that have occurred in the device landscape and in clinical trials and regulatory pathways in the last decade. The consensus-based end point definitions in this document are endorsed by the stakeholders of this document and strongly advocated for clinical trial purposes. This Academic Research Consortium-2 document provides further standardization of end point definitions for coronary device trials, incorporating advances in technology and knowledge. Their use will aid interpretation of trial outcomes and comparison among studies, thus facilitating the evaluation of the safety and effectiveness of these devices., (© 2018 American Heart Association, Inc., and European Society of Cardiology.)
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- 2018
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7. Coronary pressure-derived fractional flow reserve measurements: recommendations for standardization, recording, and reporting as a core laboratory technique. Proposals for integration in clinical trials.
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Vranckx P, Cutlip DE, McFadden EP, Kern MJ, Mehran R, and Muller O
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- Clinical Trials as Topic, Coronary Angiography standards, Coronary Vessels pathology, Coronary Vessels surgery, Expert Testimony, Humans, Outcome Assessment, Health Care methods, Outcome Assessment, Health Care standards, Reperfusion Injury etiology, Blood Vessel Prosthesis Implantation standards, Coronary Vessels physiopathology, Diagnostic Tests, Routine, Fractional Flow Reserve, Myocardial, Reperfusion Injury diagnosis
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- 2012
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8. In vivo magnetic resonance imaging of large spontaneous aortic aneurysms in old apolipoprotein E-deficient mice.
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McFadden EP, Chaabane L, Contard F, Guerrier D, Briguet A, Douek P, and Soulas EC
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- Age Factors, Animals, Aorta pathology, Aortic Aneurysm etiology, Aortic Aneurysm physiopathology, Arteriosclerosis diagnosis, Disease Models, Animal, Disease Progression, Female, Mice, Mice, Knockout, Prospective Studies, Aortic Aneurysm diagnosis, Apolipoproteins E deficiency, Arteriosclerosis physiopathology, Magnetic Resonance Imaging
- Abstract
Unlabelled: Old ApoE-deficient mice were studied in vivo by magnetic resonance imaging (MRI) to prospectively evaluate vascular remodeling associated with atherosclerotic lesions., Material and Methods: Old female ApoE-/- mice on a normal diet were followed by MRI at 2 Tesla for a 3-month period and killed for histopathology. Aortic dimensions were measured and compared., Results: High-quality in vivo MR images were obtained at 2 Tesla with in plane spatial resolution of 86 X 86 microm2. On MRI, aortic lumen enlargement (>1.5-fold dilation) was seen in 10 of 13 mice, located predominantly in the suprarenal portion of the aorta. The mean maximal diameter of the aneurysms and of the aorta above and below the aneurysm were, respectively, 1.12 +/- 0.32 mm and 0.53 +/- 0.08 mm by MRI and 1.3+/- 0.41 mm and 0.55 +/- 0.15 mm by histology. Matched histologic cross-sections of the aortic wall showed medial degradation with rupture of the internal elastic lamina at multiple sites, associated with fibrolipidic plaque containing cholesterol crystals., Conclusions: Aortic lumen enlargement was diagnosed in old ApoE-/- mice at sites with advanced atherosclerotic plaques. MRI has potential both as an in vivo imaging technique for screening mouse models for vascular wall pathology and to follow arterial remodeling associated with the disease progression.
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- 2004
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9. Anterior chordal transection impairs not only regional left ventricular function but also regional right ventricular function in mitral regurgitation.
- Author
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Le Tourneau T, Grandmougin D, Foucher C, McFadden EP, de Groote P, Prat A, Warembourg H, and Deklunder G
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- Cardiac Surgical Procedures methods, Echocardiography, Doppler, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve physiopathology, Mitral Valve surgery, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency physiopathology, Prospective Studies, Radionuclide Angiography, Stroke Volume, Survival Rate, Treatment Outcome, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right physiopathology, Cardiac Surgical Procedures adverse effects, Chordae Tendineae surgery, Mitral Valve Insufficiency surgery, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Right etiology
- Abstract
Background: Preservation of annuloventricular continuity through the chordae tendinae aims to maintain left ventricular (LV) function and thus improve postoperative prognosis. This study was designed to prospectively investigate the effect of anterior chordal transection on global and regional LV and right ventricular (RV) function in mitral regurgitation (MR)., Methods and Results: Sixty-five patients with severe MR underwent radionuclide angiography before and after either mitral valve (MV) repair (42 patients) or replacement with anterior chordal transection (23 patients). LV and RV ejection fractions (EF) were determined at rest. Both ventricles were divided into 9 regions to analyze regional EF and the effect of anteromedial translation related to surgery. After surgery there was a significant decrease in LVEF (P=0.038) and an increase in RVEF (P=0.036). However, LVEF did not change after MV repair (63.8+/-9.9% to 62.6+/-10.3%), whereas RVEF improved (40.7+/-10.1% to 44.5+/-8.1%, P=0.027). In contrast, LVEF decreased after MV replacement (61.7+/-10.1% to 57.2+/-9.9%, P=0.03), and RVEF was unchanged (40.9+/-10.9% to 41.3+/-9.1%). LVEF 4 and 5, in the area of anterior papillary muscle insertion, were impaired after MV replacement compared with MV repair (region 4, 77.6+/-16.7% versus 87.7+/-10.8%, P=0.005, and region 5, 73.9+/-19.3% versus 89.9+/-13.1%, P<0.001). Moreover, anterior chordal transection led to a significant impairment in the apicoseptal region of the RV (RVEF 4, 50.3+/-15.6% versus 59.3+/-13.8%, P=0.02)., Conclusions: Anterior chordal transection during MV replacement for MR impairs not only regional LV function but also regional RV function.
- Published
- 2001
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10. Patency of percutaneous transluminal coronary angioplasty sites at 6-month angiographic follow-up: A key determinant of survival in diabetics after coronary balloon angioplasty.
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Van Belle E, Ketelers R, Bauters C, Périé M, Abolmaali K, Richard F, Lablanche JM, McFadden EP, and Bertrand ME
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- Aged, Coronary Angiography, Coronary Disease mortality, Coronary Disease physiopathology, Diabetic Angiopathies mortality, Female, Follow-Up Studies, Heart Ventricles pathology, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Survival Rate, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Diabetic Angiopathies therapy
- Abstract
Background: Several reports have demonstrated a high mortality rate in diabetic patients treated by standard coronary balloon angioplasty. No clear explanation has been provided for this finding., Methods and Results: Consecutive diabetic patients successfully treated by standard coronary balloon angioplasty (n=604) were enrolled in a follow-up program including repeated angiography at 6 months and long-term clinical follow-up. Clinical follow-up was available in 603 patients (99.8%). Twelve patients died, 2 underwent bypass surgery before scheduled repeated angiography, and 76 declined angiography. Determinants of long-term mortality were analyzed in the 513 patients with angiography at 6 months and long-term clinical follow-up (mean follow-up, 6.5+/-2.4 years). On the basis of the results of repeated angiography, 3 groups of patients were defined: group 1, 162 patients without restenosis (32%); group 2, 257 patients with nonocclusive restenosis (50%); and group 3, 94 patients with coronary occlusion (18%). Overall actuarial 10-year mortality rate was 36%. Actuarial 10-year mortality was 24% in group 1, 35% in group 2, and 59% in group 3 (P:<0.0001). Multivariate analysis demonstrated that coronary occlusion was a strong and independent correlate of long-term total mortality (hazard ratio, 2.16; 95% CI, 1.43 to 3.26; P:=0.0003) and cardiac mortality (hazard ratio, 2.38; 95% CI, 1.48 to 3.85; P:=0.0004)., Conclusions: This study demonstrates that restenosis, especially in its occlusive form, is a major determinant of long-term mortality in diabetic patients after coronary balloon angioplasty.
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- 2001
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11. Mid-term comparative follow-up after aortic valve replacement with Carpentier-Edwards and Pericarbon pericardial prostheses.
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Le Tourneau T, Savoye C, McFadden EP, Grandmougin D, Carton HF, Hennequin JL, Dubar A, Fayad G, and Warembourg H
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- Aged, Aged, 80 and over, Female, Follow-Up Studies, Heart Valve Prosthesis Implantation instrumentation, Heart Valve Prosthesis Implantation methods, Humans, Male, Middle Aged, Prosthesis Failure, Aortic Valve surgery, Aortic Valve Stenosis surgery, Bioprosthesis, Heart Valve Prosthesis
- Abstract
Background: The first generation of pericardial valves had a high rate of premature deterioration. The aim of this study was to compare the outcome after aortic valve replacement with second generation pericardial prostheses (Pericarbon and Carpentier-Edwards)., Methods and Results: Between 1987 and 1994, 162 patients underwent aortic valve replacement with either a Pericarbon (n=81, 69+/-11 years) or a Carpentier-Edwards (n=81, 70+/-11 years) pericardial prosthesis. Mean follow-up was 4.4+/-2.7 years for Pericarbon and 4.8+/-2.4 years for Carpentier-Edwards valves (P=0. 27), giving a total follow-up of 745 patient-years. Thirty-day mortality and 5-year actuarial survival were, respectively, 6.2% and 63.2+/-5.7% in the Pericarbon group and 6.2% and 63.5+/-5.6% in the Carpentier-Edwards group. At 8 years, freedom from (and linearized rates per patient-year) thromboembolism, structural failure, and all valve-related events were, respectively, 91.8+/-3.6% (1.4%), 76. 9+/-8.7% (2.5%), and 58.4+/-9.3% (5.6%) in the Pericarbon group and 94.4+/-2.7% (1%), 100% (0%, P<0.01), and 88.8+/-3.7% (2%, P<0.05) in the Carpentier-Edwards group. There were 9 (11.1%) Pericarbon structural failures related predominantly to severe calcification and stenosis. The actual reoperation rate was 7.4% (1.6% per patient-year) in the Pericarbon group for fibrocalcific degeneration (n=3), periprosthetic leak (n=1), endocarditis (n=1), and aortic dissection (n=1). There was neither structural valve failure nor valve reoperation in the Carpentier-Edwards group. Echocardiographic review of 70 patients from 85 survivors (82.3%) found 4 additional Pericarbon valves with signs of early structural failure but no Carpentier-Edwards valve with such changes., Conclusions: Eight years after aortic valve replacement, Pericarbon pericardial prostheses compared unfavorably with Carpentier-Edwards pericardial prostheses, with a high incidence of structural valve failure and reoperation.
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- 1999
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12. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study.
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Bertrand ME, Legrand V, Boland J, Fleck E, Bonnier J, Emmanuelson H, Vrolix M, Missault L, Chierchia S, Casaccia M, Niccoli L, Oto A, White C, Webb-Peploe M, Van Belle E, and McFadden EP
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- Administration, Oral, Aged, Anticoagulants adverse effects, Arterial Occlusive Diseases prevention & control, Aspirin adverse effects, Aspirin therapeutic use, Coronary Disease complications, Drug Therapy, Combination, Female, Follow-Up Studies, Hemorrhage prevention & control, Heparin therapeutic use, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors adverse effects, Ticlopidine adverse effects, Ticlopidine therapeutic use, Treatment Outcome, Anticoagulants therapeutic use, Coronary Disease therapy, Elective Surgical Procedures, Platelet Aggregation Inhibitors therapeutic use, Stents
- Abstract
Background: Dual therapy with ticlopidine and aspirin has been shown to be as effective as or more effective than conventional anticoagulation in patients with an optimal result after implantation of intracoronary metallic stents. However, the safety and efficacy of antiplatelet therapy alone in an unselected population has not been evaluated., Methods: Patients were randomized to conventional anticoagulation or to treatment with antiplatelet therapy alone. Indications for stenting were classified as elective (decided before the procedure) or unplanned (to salvage failed angioplasty or to optimize the results of balloon angioplasty). After stenting, patients received aspirin and either ticlopidine or conventional anticoagulation (heparin or oral anticoagulant). The primary end point was the occurrence of bleeding or peripheral vascular complications; secondary end points were cardiac events (death, infarction, or stent occlusion) and duration of hospitalization., Results: In 13 centers, 236 patients were randomized to anticoagulation and 249 to antiplatelet therapy. Stenting was elective in 58% of patients and unplanned in 42%. Stent implantation was successfully achieved in 99% of patients. A primary end point occurred in 33 patients (13.5%) in the antiplatelet group and 48 patients (21%) in the anticoagulation group (odds ratio=0.6 [95% CI 0.36 to 0.98], P=0.03). Major cardiac-related events in electively stented patients were less common (odds ratio=0.23 [95% CI 0.05 to 0.91], P=0.01) in the antiplatelet group (3 of 123, 2.4%) than the anticoagulation group (11 of 111, 9.9%). Hospital stay was significantly shorter in the antiplatelet group (4.3+/-3.6 versus 6. 4+/-3.7 days, P=0.0001)., Conclusions: Antiplatelet therapy after coronary stenting significantly reduced rates of bleeding and subacute stent occlusion compared with conventional anticoagulation.
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- 1998
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13. Coronary angioscopic findings in the infarct-related vessel within 1 month of acute myocardial infarction: natural history and the effect of thrombolysis.
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Van Belle E, Lablanche JM, Bauters C, Renaud N, McFadden EP, and Bertrand ME
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- Angioscopy, Coronary Angiography, Coronary Thrombosis drug therapy, Coronary Thrombosis pathology, Female, Humans, Male, Middle Aged, Time Factors, Coronary Vessels pathology, Myocardial Infarction drug therapy, Myocardial Infarction pathology, Thrombolytic Therapy
- Abstract
Background: Limited angioscopic information is available on the natural history of infarct-related plaque after myocardial infarction (MI), in particular the effect of thrombolysis., Methods and Results: We studied with angioscopy the morphological characteristics of the infarct-related lesion in 56 patients between 24 hours and 4 weeks after MI. Forty of these patients were initially treated with a thrombolytic agent. Most lesions were complex (complex + ulcerated shape = 54%). The predominant color of the plaque was yellow in 79% of cases; only 6% were uniformly white. Angioscopically visible thrombus was found in 77% of cases. Despite angioscopic evidence of instability, only 7% of the patients had post-MI angina. During the 1-month time window since the occurrence of MI, there was no significant difference in the angioscopic appearance of the plaque except for a slight increase in uniformly white plaques (P=.07). The use of a thrombolytic agent at the onset of MI was associated with a reduction in thrombus size and less protruding thrombi (P=.02) but not with a decreased frequency of plaque containing thrombi. Furthermore, a trend for more frequently ulcerated plaques (45% versus 16%, P=.06) was associated with the use of a thrombolytic agent., Conclusions: These results suggest that healing of the infarct-related lesion requires more than 1 month and that an "unstable" yellow plaque with adherent thrombus is common during that period. This finding may partly explain the unique behavior of recent infarct-related lesions, which are more prone to occlude than other lesions.
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- 1998
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14. Effect of nadroparin, a low-molecular-weight heparin, on clinical and angiographic restenosis after coronary balloon angioplasty: the FACT study. Fraxiparine Angioplastie Coronaire Transluminale.
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Lablanche JM, McFadden EP, Meneveau N, Lusson JR, Bertrand B, Metzger JP, Legrand V, Grollier G, Macaya C, de Bruyne B, Vahanian A, Grentzinger A, Masquet C, Wolf JE, Tobelem G, Fontecave S, Vacheron A, d'Azemar P, and Bertrand ME
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- Adolescent, Adult, Aged, Anticoagulants adverse effects, Double-Blind Method, Female, Hemorrhage chemically induced, Humans, Male, Middle Aged, Nadroparin adverse effects, Prospective Studies, Recurrence, Treatment Outcome, Angioplasty, Balloon, Coronary, Anticoagulants therapeutic use, Coronary Angiography, Coronary Disease diagnostic imaging, Coronary Disease therapy, Nadroparin therapeutic use
- Abstract
Background: Experimental studies suggest that the antiproliferative effect of heparin after arterial injury is maximized by pretreatment. No previous studies of restenosis have used a pretreatment strategy. We designed this study to determine whether treatment with nadroparin, a low-molecular-weight heparin, started 3 days before the procedure and continued for 3 months, affected angiographic restenosis or clinical outcome after coronary angioplasty., Methods and Results: In a prospective multicenter, double-blind, randomized trial, elective coronary angioplasty was performed on 354 patients who were treated with daily subcutaneous nadroparin (0.6 mL of 10,250 anti-Xa IU/mL) or placebo injections started 3 days before angioplasty and continued for 3 months. Angiography was performed just before and immediately after angioplasty and at follow-up. The primary study end point was angiographic restenosis, assessed by quantitative coronary angiography 3 months after balloon angioplasty. Clinical follow-up was continued up to 6 months. Clinical and procedural variables and the occurrence of periprocedural complications did not differ between groups. At angiographic follow-up, the mean minimal lumen diameter and the mean residual stenosis in the nadroparin group (1.37+/-0.66 mm, 51.9+/-21.0%) did not differ from the corresponding values in the control group (1.48+/-0.59 mm, 48.8+/-18.9%). Combined major cardiac-related clinical events (death, myocardial infarction, target lesion revascularization) did not differ between groups (30.3% versus 29.6%)., Conclusions: Pretreatment with the low-molecular-weight heparin nadroparin continued for 3 months after balloon angioplasty had no beneficial effect on angiographic restenosis or on adverse clinical outcomes.
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- 1997
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15. Restenosis rates in diabetic patients: a comparison of coronary stenting and balloon angioplasty in native coronary vessels.
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Van Belle E, Bauters C, Hubert E, Bodart JC, Abolmaali K, Meurice T, McFadden EP, Lablanche JM, and Bertrand ME
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- Aged, Coronary Angiography, Coronary Disease diagnostic imaging, Diabetic Angiopathies diagnostic imaging, Female, Humans, Male, Middle Aged, Recurrence, Treatment Outcome, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Diabetic Angiopathies therapy, Stents
- Abstract
Background: Diabetes is a major risk factor for restenosis after coronary balloon angioplasty. Recent studies have shown that coronary stenting significantly reduces restenosis compared with balloon angioplasty alone. However, limited information is available on the effect of coronary stenting in diabetic patients., Methods and Results: We designed this study to analyze the effect of diabetes on restenosis in patients treated with either balloon angioplasty or coronary stenting who were enrolled in a 6-month angiographic follow-up program. Three hundred consecutive patients, 19% of whom were diabetics, who underwent coronary stent implantation during a single-vessel procedure on native coronary vessels and who had 6-month angiographic follow-up constituted the study group (stent group). Three hundred consecutive patients who underwent 6-month angiographic follow-up after single-vessel conventional balloon angioplasty served as control patients (balloon group). Preprocedural, postprocedural, and follow-up angiograms were analyzed with quantitative angiography. In the balloon group, the restenosis rate was almost twofold higher in diabetic than in nondiabetic patients (63% versus 36%; P=.0002) owing to both a greater late loss (0.79+/-0.70 versus 0.41+/-0.61 mm, respectively; P<.0001) and a higher rate of late vessel occlusion (14% versus 3%, respectively; P<.001). In the stent group, restenosis rates were similar in diabetics and nondiabetics (25% versus 27%, respectively). Furthermore, in the stent group, late loss (0.77+/-0.65 versus 0.79+/-0.57 mm, respectively) and the rate of late vessel occlusion (2% versus 1%, respectively) did not differ significantly between diabetic and nondiabetic patients., Conclusions: Although diabetics have increased rates of restenosis and late vessel occlusion after simple balloon angioplasty, they have the same improved outcome with coronary stenting that has been documented in nondiabetic patients.
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- 1997
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16. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting.
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Amant C, Bauters C, Bodart JC, Lablanche JM, Grollier G, Danchin N, Hamon M, Richard F, Helbecque N, McFadden EP, Amouyel P, and Bertrand ME
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- Aged, Alleles, Coronary Angiography, Coronary Disease diagnostic imaging, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Odds Ratio, Prospective Studies, Recurrence, Reoperation, Risk Factors, Stents, Coronary Disease enzymology, Coronary Disease surgery, Myocardial Revascularization, Peptidyl-Dipeptidase A genetics
- Abstract
Background: Although intracoronary stent implantation significantly reduces restenosis compared with balloon angioplasty, a minority of patients still develop restenosis predominantly due to neointimal hyperplasia. Experimental studies suggest that the renin-angiotensin system is involved in neointimal hyperplasia after arterial injury. In humans, the plasma and cellular levels of ACE are associated with an I/D genetic polymorphism in the ACE gene, DD patients having higher levels., Methods and Results: We investigated a possible relation between the ACE I/D polymorphism and restenosis in 146 patients who underwent successful implantation of a Palmaz-Schatz stent and had 6-month follow-up angiography. The minimal lumen diameter (MLD) before and after the procedure did not differ significantly among the three groups of genotypes (DD, ID, and II). At follow-up, MLD had a significant inverse relationship to the number of D alleles present (DD, 1.65 +/- 0.71 mm; ID, 1.84 +/- 0.60 mm; II, 2.05 +/- 0.61 mm; P < .007). Late luminal loss during the follow-up period was significantly related to the number of D alleles (DD, 0.89 +/- 0.61 mm; ID, 0.60 +/- 0.52 mm; II, 0.40 +/- 0.53 mm; P < .0001). The relative risk of restenosis (defined as a > 50% diameter stenosis at follow-up) approximated by the adjusted odds ratio was 2.00 per number of D alleles (95% confidence interval, 1.03 to 3.88, P < .04)., Conclusions: The ACE I/D polymorphism influences the level of late luminal loss after coronary stent implantation. These results suggest that the renin-angiotensin system may be implicated in the pathogenesis of restenosis after coronary stenting.
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- 1997
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17. Relation of coronary angioscopic findings at coronary angioplasty to angiographic restenosis.
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Bauters C, Lablanche JM, McFadden EP, Hamon M, and Bertrand ME
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- Aged, Angioscopy, Coronary Angiography, Coronary Disease therapy, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Recurrence, Risk Factors, Angioplasty, Balloon, Coronary adverse effects, Coronary Disease diagnosis
- Abstract
Background: Discordant results have been reported regarding morphological predictors of restenosis after percutaneous transluminal coronary angioplasty (PTCA). These discrepancies may be related to the limitations of angiography in the study of plaque morphology., Methods and Results: We studied 117 consecutive patients who underwent successful PTCA and who underwent coronary angioscopy before and immediately after the procedure. Angiographic follow-up was performed in 99 (85%) patients. We analyzed the relationship between angioscopic variables at the time of PTCA and the occurrence of restenosis assessed by quantitative coronary angiography. Plaque shape and color had no effect on late loss in luminal diameter (late loss: smooth lesions, 0.55 +/- 0.68 mm; complex lesions, 0.76 +/- 0.60 mm; white plaques, 0.51 +/- 0.56 mm; yellow plaques, 0.65 +/- 0.72 mm; P = NS). An angioscopic protruding thrombus at the PTCA site was associated with significantly greater loss in luminal diameter (late loss: no thrombus, 0.47 +/- 0.54 mm; lining thrombus, 0.59 +/- 0.67 mm; protruding thrombus, 1.07 +/- 0.77 mm; P < .05). Dissection assessed by angioscopy immediately after PTCA had no effect on late loss in luminal diameter (late loss: no dissection, 0.60 +/- 0.60 mm; simple dissection, 0.82 +/- 0.75 mm; complex dissection, 0.57 +/- 0.80 mm; P = NS)., Conclusions: These results show that coronary angioscopy may be helpful in predicting the risk of restenosis after PTCA. The high rate of angiographic recurrence observed when PTCA is performed at thrombus-containing lesions supports a role for thrombus in the process of luminal renarrowing after PTCA.
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- 1995
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18. Relation between the deletion polymorphism of the angiotensin-converting enzyme gene and late luminal narrowing after coronary angioplasty.
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Hamon M, Bauters C, Amant C, McFadden EP, Helbecque N, Lablanche JM, Bertrand ME, and Amouyel P
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- Adult, Aged, Coronary Angiography, Coronary Disease genetics, Female, Follow-Up Studies, Gene Deletion, Humans, Male, Middle Aged, Polymorphism, Genetic, Recurrence, Risk Factors, Angioplasty, Balloon, Coronary, Coronary Disease diagnostic imaging, Coronary Disease therapy, Peptidyl-Dipeptidase A genetics
- Abstract
Background: The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been implicated in the pathogenesis of coronary artery disease. The deletion allele is strongly associated with the level of circulating ACE and is a potent risk factor for myocardial infarction. Recently, the deletion allele was also associated with the occurrence of visually diagnosed restenosis after percutaneous transluminal coronary angioplasty (PTCA) in a selected population of patients with acute myocardial infarction., Methods and Results: We investigated the influence of the ACE I/D polymorphism on the occurrence of restenosis after PTCA with the use of quantitative coronary angiography. ACE I/D genotypes were characterized in 118 consecutive patients who had one-vessel disease and were undergoing systematic angiographic follow-up. Coronary angiograms were analyzed before and after PTCA and at follow-up (7.4 +/- 3.0 months). Before PTCA, there were no clinical or angiographic differences among the three groups of genotypes (DD, n = 39; ID, n = 62; II, n = 17). After PTCA, the mean differences in minimal luminal diameter between post-PTCA and pre-PTCA angiograms (acute gain) were identical in the three groups, as was the mean percent residual stenosis. At follow-up angiography, the mean difference in minimal coronary luminal diameter between post-PTCA and follow-up angiograms (late loss) was not significantly different in the three groups of genotypes. The percentage of patients with restenosis defined as a > 50% stenosis was identical in the three groups., Conclusions: In this quantitative study, the I/D polymorphism of the ACE gene had no influence on the occurrence of restenosis after coronary angioplasty.
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- 1995
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19. Two-pronged antiplatelet therapy with aspirin and ticlopidine without systemic anticoagulation: an alternative therapeutic strategy after bailout stent implantation.
- Author
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Van Belle E, McFadden EP, Lablanche JM, Bauters C, Hamon M, and Bertrand ME
- Subjects
- Aged, Aspirin administration & dosage, Coronary Disease drug therapy, Drug Therapy, Combination, Female, Heparin administration & dosage, Heparin therapeutic use, Humans, Injections, Intravenous, Male, Middle Aged, Prognosis, Prospective Studies, Ticlopidine administration & dosage, Angioplasty, Balloon, Coronary, Aspirin therapeutic use, Coronary Disease therapy, Postoperative Complications prevention & control, Stents, Ticlopidine therapeutic use
- Abstract
Background: Intracoronary stent implantation for failed angioplasty is associated with a relatively high incidence of coronary and peripheral complications. On the basis of previous clinical and experimental data, we investigated a protocol of intensive antiplatelet therapy, with aspirin (200 mg) and ticlopidine (500 mg), without oral anticoagulation, and with only periprocedural heparin, after stent implantation., Methods: Between November 1993 and May 1994, 650 patients underwent balloon angioplasty in our institution. Stent implantation was attempted in 45 patients because of acute (58%) or threatened acute (22%) closure, or because the result of the primary angioplasty was inadequate (9%)., Results: Stents were successfully implanted in 42 (93%) patients. Two patients were not enrolled in the protocol (referring physician preference in one, metallic heart valve prosthesis in the other). In the remaining 40 patients, two sustained Q-wave infarctions and three sustained non Q-wave infarctions, which were already established at the time of stent implantation. No further clinical events occurred during hospitalization. During follow-up (mean 3.2 months) none of the patients died and none developed unstable angina or myocardial infarction. Ticlopidine-related rash occurred in two patients who were consequently put on warfarin therapy instead., Conclusions: Antiplatelet therapy with ticlopidine and aspirin, without systemic anticoagulation, appears to be a promising alternative to the classical approach with heparin and warfarin therapy, which requires intensive biological monitoring. This approach considerably simplifies patient management, and it could reduce the need for prolonged hospitalization.
- Published
- 1995
- Full Text
- View/download PDF
20. Restenosis after delayed coronary angioplasty of the culprit vessel in patients with a recent myocardial infarction treated by thrombolysis.
- Author
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Bauters C, Khanoyan P, McFadden EP, Quandalle P, Lablanche JM, and Bertrand ME
- Subjects
- Coronary Angiography, Coronary Disease diagnostic imaging, Coronary Disease epidemiology, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Incidence, Male, Middle Aged, Multivariate Analysis, Recurrence, Retrospective Studies, Time Factors, Treatment Outcome, Ventricular Function, Left physiology, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Myocardial Infarction drug therapy, Thrombolytic Therapy
- Abstract
Background: Clinical follow-up after percutaneous transluminal coronary angioplasty (PTCA) of an infarct-related lesion has demonstrated a low incidence of recurrent symptoms and repeated revascularization. In the absence of systematic angiographic follow-up, this low rate of clinical restenosis may reflect either a truly lower incidence of anatomic restenosis or the lack of recurrent symptoms in patients with extensive infarction in the territory of the restenotic vessel., Methods and Results: We studied 300 consecutive patients who, after a thrombolysis for myocardial infarction, underwent delayed (10.5 +/- 6 days after the myocardial infarction) PTCA of the infarct-related lesion. Procedural success was obtained in 253 patients (84%), and angiographic follow-up was performed in 205 of this group (81%) at a mean of 7.3 +/- 1.9 months. Restenosis (defined as the recurrence of > 50% stenosis) was present in 105 patients (51%). Only 34 of the 105 patients (32%) with angiographic restenosis were symptomatic; the other 68% had clinically silent restenosis. Of these 105 patients, 27 (13% of the total population undergoing follow-up angiography) had reocclusion at the dilated site at follow-up. The severity of the stenosis at follow-up and the late loss in minimal lumen diameter followed a nearly Gaussian distribution if the lesions that were totally occluded at follow-up were excluded. By multivariate analysis, two independent predictors of reocclusion were identified: a small reference diameter (P < .0005) and the presence of collateral vessels before the procedure (P < .01). Only one factor was associated with restenosis in the 178 patients who did not have reocclusion at follow-up; a Thrombolysis in Myocardial Infarction grade < or = 2 before the procedure (P < .0001). At follow-up, there was a significantly (P < .01) higher ejection fraction in patients without restenosis (56.1 +/- 13.4%) and in patients with restenosis without total occlusion (56.0 +/- 13.8%) than in patients with reocclusion (46.4 +/- 13.0%)., Conclusions: Despite a satisfactory clinical outcome, delayed PTCA of an infarct-related lesion is associated with a high rate of angiographic recurrence. Two distinct mechanisms account for recurrent stenosis: progressive luminal renarrowing as documented after angioplasty of stable lesions and reocclusion of the infarct-related lesion. Only reocclusion is associated with a deterioration in left ventricular function at follow-up.
- Published
- 1995
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21. Local lesion-related factors and restenosis after coronary angioplasty. Evidence from a quantitative angiographic study in patients with unstable angina undergoing double-vessel angioplasty.
- Author
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de Groote P, Bauters C, McFadden EP, Lablanche JM, Leroy F, and Bertrand ME
- Subjects
- Coronary Angiography methods, Electrocardiography, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Recurrence, Risk Factors, Angina, Unstable diagnostic imaging, Angina, Unstable therapy, Angioplasty, Balloon, Coronary, Coronary Disease diagnostic imaging, Coronary Disease therapy
- Abstract
Background: Restenosis rates are high when coronary angioplasty is performed in patients with unstable angina. The relative contributions of local and systemic factors to this excess risk of restenosis are unclear. To assess these, we compared changes in minimal lumen diameter and the incidence of restenosis, determined by quantitative coronary angiography, after coronary angioplasty at culprit and nonculprit lesions dilated in the course of a single procedure in patients with unstable angina., Methods and Results: We identified 67 consecutive patients with unstable angina in whom two lesions, in different vessels, were dilated during the same procedure. Lesions were designated as culprit or nonculprit on the basis of the location of ECG changes during chest pain combined with assessment of the angiographic characteristics of the lesions. With these criteria, 43 patients had identifiable culprit lesions. Stenosis severity before and immediately after angioplasty and at follow-up was assessed with quantitative angiography. Angiographic follow-up was performed in 91% (39 patients) of this subgroup. Culprit lesions were more severe (P < .02) than nonculprit lesions. The late loss at culprit lesions (0.87 +/- 0.75 mm) was significantly (P < .01) greater than the equivalent value for nonculprit lesions (0.33 +/- 0.69 mm). With a categorical definition (> 50% stenosis at follow-up), restenosis occurred at 67% of culprit lesions and at 32% of nonculprit lesions (P < .01)., Conclusions: The greater loss in minimal lumen diameter and the consequent higher rate of restenosis at culprit compared with nonculprit lesions suggest that local "lesion-related" factors are an important determinant of the high rate of restenosis when coronary angioplasty is performed in patients with unstable angina.
- Published
- 1995
- Full Text
- View/download PDF
22. Evidence for time-dependent activation of monocytes in the systemic circulation in unstable angina but not in acute myocardial infarction or in stable angina.
- Author
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Jude B, Agraou B, McFadden EP, Susen S, Bauters C, Lepelley P, Vanhaesbroucke C, Devos P, Cosson A, and Asseman P
- Subjects
- Adult, Aged, Aged, 80 and over, Blood Coagulation, Female, Fibrinogen metabolism, Humans, Male, Middle Aged, Peptide Fragments metabolism, Prospective Studies, Prothrombin metabolism, Thromboplastin metabolism, Time Factors, Angina Pectoris blood, Angina, Unstable blood, Monocytes physiology, Myocardial Infarction blood
- Abstract
Background: Platelet activation plays a pivotal role in the pathogenesis of acute coronary disease. Monocytes are involved in the progression of atherosclerosis and are potent activators of blood coagulation through their ability to synthesize tissue factor (TF). The aim of this study was to compare markers of monocyte and coagulation activation in the systemic blood of patients with unstable angina, acute myocardial infarction, or stable angina., Methods and Results: We studied 26 patients with unstable angina (10 +/- 5 hours after the onset of the last episode of pain), 18 patients with acute myocardial infarction (5 +/- 4 hours after the onset of pain), and 34 patients with stable angina. We measured levels of TF expression in peripheral blood mononuclear cells (isolated by gradient centrifugation and incubated for 16 hours, with or without endotoxin stimulation), levels of plasma prothrombin fragment 1 + 2 (F1 + 2), and levels of fibrinogen in peripheral blood. In patients with unstable angina, both stimulated and unstimulated cells exhibited higher levels of TF expression than in patients with stable angina (P = .0001). In patients with acute myocardial infarction, monocyte TF activity did not differ from that in patients with stable angina. Mean levels of F1 + 2 and of fibrinogen did not differ significantly between groups. Only in the unstable angina group, a modest correlation was found between fibrinogen (r = .72, P = .005) and F1 + 2 levels (r = .54, P = .001) levels and the degree of monocyte TF expression. In patients with unstable angina, monocyte TF expression (both stimulated and unstimulated, assessed by biological activity and by antigen techniques) and fibrinogen levels were correlated with the time elapsed from the beginning of the most recent episode of pain (.61 < r < .72, .02 < P < .0001). By contrast, there was no correlation between these variables and the time from onset of pain in patients with acute myocardial infarction., Conclusions: A time-dependent activation of systemic monocytes and a time-dependent increase in fibrinogen levels occurs in unstable angina but not in myocardial infarction. These findings provide further evidence that a specific inflammatory process occurs in unstable angina. Further studies are required to determine whether monocyte activation is a cause or a consequence of plaque instability in patients with unstable angina and to clarify the interrelations between platelet and monocyte activation in these circumstances.
- Published
- 1994
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23. Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.
- Author
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Hamon M, Vallet B, Bauters C, Wernert N, McFadden EP, Lablanche JM, Dupuis B, and Bertrand ME
- Subjects
- Administration, Oral, Animals, Arteries pathology, Catheterization, Iliac Artery injuries, Iliac Artery pathology, Male, Rabbits, Time Factors, Acetylcholine pharmacology, Arginine pharmacology, Arteries injuries, Endothelium, Vascular physiopathology, Tunica Intima drug effects, Vasodilation drug effects
- Abstract
Background: Nitric oxide (NO), in addition to its potent vasorelaxant properties, may participate in growth regulation of cultured smooth muscle cells. It was recently demonstrated that in vivo endothelial injury induces the production of NO from L-arginine in the arterial wall., Methods and Results: We studied the effects of long-term administration of L-arginine, the precursor of NO, on neointimal thickening and on neoendothelium-dependent vasorelaxation 4 weeks after balloon denudation of normocholesterolemic rabbit iliac arteries. Rabbits were fed with either a standard diet or a diet supplemented with L-arginine (2.25%) in their drinking water 3 days before and during 4 weeks after balloon denudation. The effectiveness of L-arginine supplementation was confirmed by measurement of plasma arginine levels. L-Arginine had no effect on hemodynamic parameters. All animals were killed 4 weeks after balloon denudation, and a digital histomorphometric analysis of three serial nonconsecutive histological cross sections per iliac artery was performed. Intimal thickening was reduced (P < .05) from 0.43 +/- 0.08 (SE) mm2 in controls (n = 8) to 0.24 +/- 0.02 mm2 in treated animals (n = 8). Ten animals (n = 5 in each group) were used for in vitro vasoreactivity assessment 4 weeks after balloon denudation. Neoendothelium-dependent acetylcholine-induced relaxation (10(-8) mol/L to 3.10(-5) mol/L) in treated animals (Emax = -24.1 +/- 5.5%) was significantly greater than in controls (Emax = -8.9 +/- 2.2%). Endothelium-independent relaxation did not differ between groups (Emax = -58.1 +/- 6.5% in L-arginine-supplemented animals versus -52.9 +/- 6.8% in controls)., Conclusions: Our results demonstrate that L-arginine, a precursor of NO, reduces neointimal thickening after balloon denudation and improves neoendothelial-dependent acetylcholine-induced relaxation.
- Published
- 1994
- Full Text
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24. Exercise-induced ST-segment depression in patients without restenosis after coronary angioplasty. Relation to preprocedural impaired left ventricular function.
- Author
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Beregi JP, Bauters C, McFadden EP, Quandalle P, Bertrand ME, and Lablanche JM
- Subjects
- Aged, Coronary Angiography, Coronary Disease therapy, Exercise Test, Female, Humans, Male, Middle Aged, Postoperative Complications, Recurrence, Reference Values, Ventricular Function, Angioplasty, Balloon, Coronary, Electrocardiography, Heart physiopathology, Physical Exertion, Ventricular Function, Left
- Abstract
Background: ST-segment depression during exercise testing is frequently observed in the absence of restenosis after coronary angioplasty., Methods and Results: We studied the determinants of this phenomenon in 70 consecutive patients with unstable angina related to a single left anterior descending coronary artery lesion who had successful angioplasty without restenosis (< 50% stenosis by quantitative angiography). We compared preangioplasty clinical, angiographic, and hemodynamic variables in the group with positive (ExT Pos, n = 35; ST depression, 2.3 +/- 0.9 mm) and negative (ExT Neg, n = 35; ST depression, 0.3 +/- 0.5 mm) results on exercise testing at follow-up angiography. At this time, minimal lumen diameter (1.7 +/- 0.4 mm) and mean residual stenosis (34 +/- 11%) in the ExT Pos group were not significantly different from the values (1.9 +/- 0.5 mm, 38 +/- 10%) in the ExT Neg group. Before angioplasty, the ExT Pos group had a lower ejection fraction (63 +/- 8% versus 68 +/- 9%, P < .05), more marked anterior hypokinesis estimated by the extent of anterior wall contraction on quantitative ventriculography (P < .05), and a greater end-systolic volume (30 +/- 11 versus 25 +/- 9 mL/m2, P < .05) than the ExT Neg group. At follow-up angiography, regional anterior wall motion was normal in 68 patients (97%). Anterior hypokinesis before angioplasty was strongly associated (P < .01) with a positive exercise test at control (71% compared with 31% in patients with normal wall motion before angioplasty)., Conclusions: In the absence of significant epicardial stenosis after angioplasty, ST-segment depression is strongly associated with the presence of preprocedural regional ventricular dysfunction that has recovered at follow-up angiography.
- Published
- 1994
- Full Text
- View/download PDF
25. Relative prognostic value of clinical, exercise, and angiographic data after a first myocardial infarction.
- Author
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Leroy F, Lablanche JM, McFadden EP, Bauters C, and Bertrand ME
- Subjects
- Adult, Aged, Angina Pectoris diagnosis, Coronary Angiography, Coronary Artery Bypass, Discriminant Analysis, Dyspnea diagnosis, Exercise Test, Female, Humans, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction surgery, Predictive Value of Tests, Prognosis, Retrospective Studies, Survival Rate, Heart Function Tests, Myocardial Infarction mortality, Myocardial Infarction physiopathology
- Abstract
Background: Studies examining the relative value of clinical, exercise test, and angiographic data in the prediction of further clinical events after a first acute myocardial infarction (AMI) have produced conflicting results., Methods: We examined the relative value of clinical, exercise test, and angiographic data as predictors of death, recurrent infarction, and the subsequent development of angina or dyspnea in 303 consecutive patients who underwent exercise testing and coronary angiography within 2 months of an uncomplicated first acute myocardial infarction (AMI), and who were followed for 48 (+/- 22) months., Results: A combination of two clinical and two exercise variables correctly identified 79% of subsequent deaths. No variables had a predictive value for re-infarction. A combination of two exercise variables correctly identified 75% of patients who developed angina during follow up. A combination of two clinical variables and one exercise variable correctly identified 76% of patients who developed dyspnea during follow up., Conclusions: Exercise testing provided useful prognostic information independent of clinical data. Combining clinical and exercise data identified a group of patients at low risk of future events. In this low-risk group of patients, the addition of angiographic data did not provide additional prognostic information.
- Published
- 1993
- Full Text
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26. Effect of ketanserin on proximal and distal coronary constrictor responses to intracoronary infusion of serotonin in patients with stable angina, patients with variant angina, and control patients.
- Author
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McFadden EP, Bauters C, Lablanche JM, Leroy F, Clarke JG, Henry M, Schandrin C, Davies GJ, Maseri A, and Bertrand ME
- Subjects
- Adult, Angina Pectoris diagnostic imaging, Angina Pectoris, Variant diagnostic imaging, Coronary Angiography, Electrocardiography, Female, Humans, Male, Middle Aged, Reference Values, Angina Pectoris physiopathology, Angina Pectoris, Variant physiopathology, Coronary Circulation drug effects, Ketanserin pharmacology, Serotonin pharmacology, Vasoconstriction
- Abstract
Background: Serotonin, released by aggregating platelets, may contribute to or cause myocardial ischemia by constricting epicardial vessels. Experimental studies suggest that this constriction is mediated by two distinct serotonin receptor subtypes: 5-hydroxytryptamine1-like (S1-like) and 5-hydroxytryptamine2 (S2)., Methods and Results: To determine the relative contribution of S1-like and S2 receptors to the vasoconstrictor effects of serotonin, we studied the effect of ketanserin (0.75 mg, intracoronary), a selective S2 receptor antagonist, on the constrictor response of human coronary vessels to intracoronary infusions of serotonin. In control patients (n = 7), serotonin (10(-4) mol/l) caused significant (p less than 0.05) constriction only in distal segments, which was significantly (p less than 0.05) inhibited by ketanserin. In stable angina patients (n = 8), serotonin (10(-4) mol/l) caused significant constriction in proximal (p less than 0.01) and distal (p less than 0.01) segments, which was significantly inhibited by ketanserin in proximal (p less than 0.05) but not distal (p = 0.30) segments. In patients with variant angina (n = 3), epicardial occlusion at the site of preexisting stenoses in proximal locations occurred at infused concentrations of 10(-6) (one patient) or 10(-5) (two patients) mol/l. The infusion of the same concentration of serotonin after ketanserin again caused epicardial occlusion., Conclusions: Our results suggest that functionally important S1-like receptors that mediate vasoconstriction exist in the epicardial vessels of patients with stable or variant angina. Their activation, either at hyperreactive sites in patients with variant angina or in the distal epicardial vessels of patients with chronic stable angina, may contribute to or cause myocardial ischemia when serotonin is released after the intracoronary activation of platelets.
- Published
- 1992
- Full Text
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