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Your search keyword '"Mayer-Suess L"' showing total 4 results
Start Over Author "Mayer-Suess L" Publisher lippincott williams & wilkins
4 results on '"Mayer-Suess L"'

1. Prime Time for a Trial Assessing Safety of Intravenous Thrombolysis in Patients Treated With Direct Oral Anticoagulants.

Author

Boehme C, Mayer-Suess L, Mikšová D, Lang W, Knoflach M, and Kiechl S

Subjects
Humans, Stroke drug therapy, Administration, Oral, Administration, Intravenous, Fibrinolytic Agents adverse effects, Fibrinolytic Agents therapeutic use, Fibrinolytic Agents administration & dosage, Ischemic Stroke drug therapy, Thrombolytic Therapy adverse effects, Thrombolytic Therapy methods, Anticoagulants adverse effects, Anticoagulants therapeutic use, Anticoagulants administration & dosage
Abstract

Competing Interests: Disclosures Dr Kiechl reports grants from the Austrian Research Promotion Agency. The other authors report no conflicts.

Published
2024
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2. Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection.

Author

Mayer-Suess L, Pechlaner R, Barallobre-Barreiro J, Boehme C, Toell T, Lynch M, Yin X, Willeit J, Gizewski ER, Perco P, Ratzinger G, Kiechl S, Mayr M, and Knoflach M

Subjects
Humans, Recurrence, Skin metabolism, Aortic Dissection diagnosis, Biomarkers metabolism, Extracellular Matrix Proteins metabolism, Neck blood supply
Abstract

Objective: To assess whether connective tissue disorder is evident in patients with spontaneous cervical artery dissection and therefore identify patients at risk of recurrence using a cutting-edge quantitative proteomics approach., Methods: In the ReSect study, all patients with spontaneous cervical artery dissection treated at the Innsbruck University Hospital since 1996 were invited to attend a standardized clinical follow-up examination. Protein abundance in skin punch biopsies (n = 50) was evaluated by a cutting-edge quantitative proteomics approach (liquid chromatography-mass spectrometry) that has hitherto not been applied to such patients., Results: Patients with 1-time single-vessel (n = 19) or multiple-vessel (n = 13) dissections did not differ between each other or compared to healthy controls (n = 12) in protein composition. Patients with recurrent spontaneous cervical artery dissection (n = 6), however, showed significantly different expression of 25 proteins compared to the other groups combined. Literature review and Gene Ontology term annotation check revealed that 13 of the differently expressed proteins play a major role in the structural integrity of connective tissue or are linked to connective tissue disorders. These proteins showed clustering to a collagen/elastin cluster and one consisting of desmosome related proteins., Conclusion: This study unravels an extracellular matrix protein signature of recurrent spontaneous cervical artery dissection. In the long run and after large-scale validation, our findings may well assist in identifying patients at risk of recurrent spontaneous cervical artery dissection and thus guide therapy., (© 2020 American Academy of Neurology.)

Published
2020
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4. The dimension of preventable stroke in a large representative patient cohort.

Author

Boehme C, Toell T, Mayer-Suess L, Domig L, Pechlaner R, Willeit K, Tschiderer L, Seekircher L, Willeit P, Griesmacher A, Knoflach M, Willeit J, and Kiechl S

Subjects
Adult, Aged, Cohort Studies, Female, Guideline Adherence, Humans, Male, Middle Aged, Risk Factors, Primary Prevention, Stroke etiology, Stroke prevention & control
Abstract

Objective: To analyze the frequency of inadequately treated risk factors in a large representative cohort of patients with acute ischemic stroke or TIA and to estimate the proportion of events potentially avertable by guideline-compliant preventive therapy compared to the status quo., Methods: A total of 1,730 patients from the Poststroke Disease Management STROKE-CARD trial (NCT02156778) were recruited between 2014 and 2017. We focused on 8 risk conditions amenable to drug therapy and 3 lifestyle risk behaviors and assessed pre-event risk factor control in retrospect., Results: The proportion of patients with at least 1 inadequately treated risk condition was 79.5% (95% confidence interval [CI] 77.6%-81.4%) and increased to 95.1% (95% CI 94.1%-96.1%) upon consideration of the lifestyle risk behaviors. Risk factor control was worse in patients with recurrent vs first-ever events ( p < 0.001), men vs women ( p = 0.003), and patients ≤75 vs >75 years of age ( p < 0.001). The estimated degree of stroke preventability ranged from 0.4% (95% CI 0.2%-0.6%) to 13.7% (95% CI 12.2%-15.2%) for the individual risk factors. Adequate control of the 5 most relevant risk factors combined (hypertension, hypercholesterolemia, atrial fibrillation, smoking, and overweight) would have averted ≈1 of 2 events or 1 in 4 with a highly conservative computation approach., Conclusions: Our study confirms the existence of a considerable gap between risk factor control recommended by guidelines and real-world stroke prevention. Our study intends to increase awareness among physicians about stroke preventability and provides a quantitative basis for the emerging discussion on how to best tackle this challenge., (© 2019 American Academy of Neurology.)

Published
2019
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