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Your search keyword '"Malee,Kathleen"' showing total 30 results
Start Over Author "Malee,Kathleen" Publisher lippincott williams & wilkins
30 results on '"Malee,Kathleen"'

1. Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy.

Author

Wagner, Thor A., Tierney, Camlin, Huang, Sharon, Nichols, Sharon, Malee, Kathleen M., Montañez, Nicole A., Coletti, Anne, Spiegel, Hans M. L., Krotje, Chelsea, Bone, Frederic, Wilkins, Megan, Abuogi, Lisa, Purswani, Murli, Bearden, Allison, Wiznia, Andrew, Agwu, Allison, Chadwick, Ellen G., Richman, Douglas, Gandhi, Monica, and Mehta, Patrick

Published
2024
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2. Acylcarnitines and Genetic Variation in Fat Oxidation Genes in HIV-infected, Antiretroviral-treated Children With and Without Myopathy.

Author

Kirmse, Brian, Hobbs, Charlotte, Aaron, Lisa, Montepiedra, Grace, Summar, Marshall, Williams, Paige L., Smith, Caitlin J., Van Dyke, Russell, Yu, Chunli, Ryckman, Kelli K., Borkowsky, William, Chadwick, Ellen, Sanders, Margaret Ann, Malee, Kathleen, Pyun, Yoonsun, Paul, Mary, Buschur, Shelley, McMullen-Jackson, Chivon, Harris, Lynnette, and Purswani, Murli

Published
2022
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6. Machine-learning classification of neurocognitive performance in children with perinatal HIV initiating de novo antiretroviral therapy.

Author

Paul, Robert H., Cho, Kyu S., Belden, Andrew C., Mellins, Claude A., Malee, Kathleen M., Robbins, Reuben N., Salminen, Lauren E., Kerr, Stephen J., Adhikari, Badri, Garcia-Egan, Paola M., Sophonphan, Jiratchaya, Aurpibul, Linda, Thongpibul, Kulvadee, Kosalaraksa, Pope, Kanjanavanit, Suparat, Ngampiyaskul, Chaiwat, Wongsawat, Jurai, Vonthanak, Saphonn, Suwanlerk, Tulathip, and Valcour, Victor G.

Published
2020
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7. Increased Risk of Executive Function and Emotional Behavioral Problems Among Virologically Well-Controlled Perinatally HIV-Infected Adolescents in Thailand and Cambodia.

Author

Kerr, Stephen J., Thanyawee Puthanakit, Malee, Kathleen M., Kulvadee Thongpibul, Penh Sun Ly, Jiratchaya Sophonphan, Tulathip Suwanlerk, Kosalaraksa, Pope, Pradthana Ounchanum, Aurpibul, Linda, Suparat Kanjanavanit, Chaiwat Ngampiyaskul, Chettra, Kea, Robbins, Reuben, Paul, Robert, Jintanat Ananworanich, and Mellin, Claude A.

Published
2019
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8. Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.

Author

Patel, Payal B. MD, Apornpong, Tanakorn MS, Puthanakit, Thanyawee MD, Thongpibul, Kulvadee PhD, Kosalaraksa, Pope MD, Hansudewechakul, Rawiwan MD, Kanjanavanit, Suparat MD, Ngampiyaskul, Chiawat MD, Luesomboon, Wicharn MD, Wongsawat, Jurai MD, Sun, Ly Penh MD, Chettra, Kea MD, MSc, Saphonn, Vonthanak MD, MSc, PhD, Mellins, Claude A. PhD, Malee, Kathleen PhD, Spudich, Serena MD, MA, Ananworanich, Jintanat MD, PhD, Kerr, Stephen J. MIPH, PhD, and Paul, Robert PhD

Published
2019
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10. Emotional and behavioral resilience among children with perinatally acquired HIV in Thailand and Cambodia.

Author

Malee, Kathleen M., Kerr, Stephen, Paul, Robert, Puthanakit, Thanyawee, Thongpibul, Kulvadee, Kosalaraksa, Pope, Ounchanum, Pradthana, Kanjanavanit, Suparat, Aurpibul, Linda, Ngampiyaskul, Chaiwat, Luesomboon, Wicharn, Wongsawat, Jurai, Vonthanak, Saphonn, Ly, Penh S., Chettra, Kea, Suwanlerk, Tulathip, Sophonphan, Jiratchaya, Valcour, Victor, Ananworanich, Jintanat, and Mellins, Claude A.

Published
2019
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11. Impact of Perinatally Acquired HIV Disease Upon Longitudinal Changes in Memory and Executive Functioning.

Author

Malee, Kathleen M., Chernoff, Miriam C., Sirois, Patricia A., Williams, Paige L., Garvie, Patricia A., Kammerer, Betsy L., Harris, Lynnette L., Nozyce, Molly L., Yildirim, Cenk, and Nichols, Sharon L.

Abstract

Background: Little is known regarding effects of perinatally acquired HIV infection (PHIV) on longitudinal change in memory and executive functioning (EF) during adolescence despite the importance of these skills for independence in adulthood. Methods: PHIV (n = 144) and perinatally HIV-exposed uninfected youth (PHEU, n = 79), ages 12-17, completed standardized tests of memory and EF at baseline and 2 years later. Changes from baseline for each memory and EF outcome were compared between PHEU and PHIV youth with (PHIV/C, n = 39) and without (PHIV/non-C, n = 105) history of CDC class C (AIDS-defining) diagnoses. Among PHIV youth, associations of baseline and past disease severity with memory and EF performance at follow-up were evaluated using adjusted linear regression models. Results: Participants were primarily black (79%); 16% were Hispanic; 55% were female. Mean memory and EF scores at follow-up generally fell in the low-average to average range. Pairwise comparison of adjusted mean change from baseline to follow-up revealed significantly greater change for PHIV/non-C compared with PHEU youth in only one verbal recognition task, with a difference in mean changes for PHIV/non-C versus PHEU of 20.99 (95% CI: 21.80 to 20.19; P = 0.02). Among youth with PHIV, better immunologic status at baseline was positively associated with follow-up measures of verbal recall and recognition and cognitive inhibition/flexibility. Past AIDS-defining diagnoses and higher peak viral load were associated with lower performance across multiple EF tasks at follow-up. Conclusions: Youth with PHIV demonstrated stable memory and EF during a 2-year period of adolescence, allowing cautious optimism regarding long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2017
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20. Prevalence, Incidence, and Persistence of Psychiatric and Substance Use Disorders Among Mothers Living With HIV.

Author

Malee, Kathleen M., Mellins, Claude A., Huo, Yanling, Tassiopoulos, Katherine, Smith, Renee, Sirois, Patricia A., Allison, Susannah M., Kacanek, Deborah, Kapetanovic, Suad, Williams, Paige L., Grant, Mitzie L., Marullo, Daniel, and Aidala, Angela A.

Abstract

To evaluate prevalence, incidence, remission, and persistence of psychiatric and substance use disorders among HIV-infected mothers and identify biopsychosocial correlates.HIV-infected mothers (n = 1223) of HIV-exposed uninfected children enrolled in a prospective cohort study; HIV-uninfected mothers (n = 128) served as a comparison group. Mothers provided sociodemographic and health information and completed the Client Diagnostic Questionnaire (CDQ). Prevalence of any psychiatric or substance use disorder at initial evaluation was compared between the 2 groups. Incident, remitting, and persisting disorders were identified for 689 mothers with HIV who completed follow-up CDQs. We used logistic regression to evaluate adjusted associations of biopsychosocial characteristics with presence, incidence, remission, and persistence of disorders.Thirty-five percent of mothers screened positive for any psychiatric or substance use disorder at initial evaluation, with no difference by maternal HIV status (P = 1.00). Among HIV-infected mothers, presence of any disorder was associated with younger age [adjusted odds ratio (aOR): 1.39; 95% CI: 1.09 to 1.75], single parenthood (aOR: 1.35; 95% CI: 1.08 to 1.68), and functional limitations (aOR: 2.29; 95% CI: 1.81 to 2.90). Incident disorders were associated with functional limitations (aOR: 1.92; 95% CI: 1.10 to 3.30). Among HIV-infected mothers with a disorder at initial evaluation (n = 238), 61% had persistent disorders. Persistent disorders were associated with lower income (aOR: 2.44; 95% CI: 1.33 to 4.76) and functional limitations (aOR: 3.19; 95% CI: 1.87 to 5.48). Receipt of treatment for any disorder was limited: 4.5% at study entry, 7% at follow-up, 5.5% at both entry and follow-up.Psychiatric and substance use disorders remain significant comorbid conditions among HIV-infected mothers and require accessible evidence-informed treatment. [ABSTRACT FROM AUTHOR]

Published
2014
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27. Impact of medications prescribed for treatment of attention-deficit hyperactivity disorder on physical growth in children and adolescents with HIV.

Author

Sirois PA, Montepiedra G, Kapetanovic S, Williams PL, Pearson DA, Malee K, Garvie PA, Kammerer BL, Nichols SL, Nozyce ML, Mintz M, Mitchell WG, Oleske JM, IMPAACT/PACTG 219C Team, Sirois, Patricia A, Montepiedra, Grace, Kapetanovic, Suad, Williams, Paige L, Pearson, Deborah A, and Malee, Kathleen

Published
2009
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30. Relationships between markers of vascular dysfunction and neurodevelopmental outcomes in perinatally HIV-infected youth.

Author

Kapetanovic S, Leister E, Nichols S, Miller T, Tassiopoulos K, Hazra R, Gelbard HA, Malee KM, Kammerer B, Mendez AJ, and Williams PL

Subjects
Adolescent, Antiretroviral Therapy, Highly Active, Atherosclerosis virology, CD4 Lymphocyte Count, Child, Cognition Disorders blood, Cognition Disorders virology, Cross-Sectional Studies, Endothelium, Vascular drug effects, Endothelium, Vascular virology, Female, HIV Infections drug therapy, HIV Infections virology, Humans, Male, Prospective Studies, RNA, Viral, United States, Viral Load, Biomarkers blood, Cognition Disorders physiopathology, Endothelium, Vascular physiopathology, HIV Infections physiopathology, HIV-1
Abstract

Objective: To examine the relationship between markers of vascular dysfunction and neurodevelopmental status in pediatric HIV disease., Design: A cross-sectional design within a prospective, 15-site cohort study conducted in the United States., Methods: Nine vascular biomarkers were examined in 89 HIV-infected children: soluble P-selectin/sCD62P, fibrinogen, adiponectin, monocyte chemoattractant protein-1/CCL-2, interleukin-6, C-reactive protein, soluble vascular cell adhesion molecule-1/sCD106, sE-selectin/sCD62E, and soluble intercellular adhesion molecule-1/sCD54. The Wechsler Intelligence Scale for Children-Fourth edition (WISC-IV) was administered yielding indices for verbal comprehension, perceptual reasoning, working memory and processing speed, and overall composite Full-Scale IQ score. Linear regression models were used to evaluate neurodevelopmental status (measured by WISC-IV scores) as a function of each biomarker while adjusting for demographics, disease severity, and receipt of HAART. Biomarker levels were evaluated in quartiles to evaluate trends in WISC-IV responses., Results: Among the 89 HIV-infected children (median age = 12 years), 56% were girls, 71% black, 16% Hispanic, and 43% had yearly household income below US $20,000. Log (soluble P-selectin) was significantly correlated with all WISC-IV scores; adjusted slopes showed 6-11-point average decrease in scores for each one log unit increase in soluble P-selectin. Final linear regression models for log (fibrinogen) adjusted for sociodemographic and disease characteristics also indicated a negative correlation with all WISC-IV scores (13-30-point decrease for each one log unit increase in fibrinogen); these decreases were significant in the verbal comprehension, perceptual reasoning, and Full-Scale IQ scores., Conclusion: Proinflammatory microvascular and immunologic mechanisms may be involved in neurodevelopmental impairment in children with perinatally acquired HIV disease.

Published
2010
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