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Your search keyword '"Kim, S. -J"' showing total 130 results
Start Over Author "Kim, S. -J" Publisher lippincott williams & wilkins
130 results on '"Kim, S. -J"'

1. Synergistic antinociception between zaprinast and morphine in the spinal cord of rats on the formalin test.

Author

Yoon, Myung Ha, Choi, J. I., Kim, S. J., Kim, C. M., Bae, H. B., and Chung, S. T.

Subjects
CYCLIC guanylic acid, PHOSPHODIESTERASES, DOSE-effect relationship in pharmacology, LABORATORY rats, MORPHINE, CATHETERIZATION
Abstract

Background and objective: The cyclic guanosine monophosphate level, which causes an antinociception, is increased in cells as a direct result of phosphodiesterase inhibition. This study used a nociceptive test to examine the nature of the pharmacological interaction between intrathecal zaprinast, a phosphodiesterase inhibitor, and morphine. Methods: Catheters were inserted into the intrathecal space through an incision in the atlanto-occipital membrane of male Sprague-Dawley rats. As a nociceptive model, 50 pL of a 5% formalin solution was injected into the hind paw. After observing the effect of zaprinast (37, 111, 369 nmol) and morphine (1, 4, 10, 40 nmol) alone, the interactions of their combination were examined by an isobolographic analysis. Results: Intrathecal zaprinast (P < 0.05) and morphine (P < 0.05) dose-dependently suppressed the flinching observed during phase 1 and phase 2 in the formalin test. The ED50 values (95% confidence intervals) of zaprinast and morphine in phase 1 were 161.9 (87.9–298.3) and 11.6 nmol (4.8–27.9 nmol), respectively. The phase 2 ED50 values (95% confidence intervals) of zaprinast and morphine were 229.9 (142.5–370.9) and 3.9 nmol (1.9–7.6 nmol), respectively. Isobolographic analysis revealed a synergistic interaction after intrathecal delivery a zaprinast-morphine mixture in both phases. The ED50 values of (95% confidence intervals) zaprinast in the combination of zaprinast with morphine in phase 1 and phase 2 were 14.2 (4.9–40.6) and 10.4 nmol (3–35.9 nmol), respectively. Conclusions: Intrathecal zaprinast and morphine are effective against acute pain and facilitated pain state. Zaprinast interacts synergistically with morphine. [ABSTRACT FROM AUTHOR]

Published
2006
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2. Arthroscopically assisted treatment of avulsion fractures of the posterior cruciate ligament from the tibia.

Author

Kim, S J, Shin, S J, Choi, N H, and Cho, S K

Subjects
*ANTERIOR cruciate ligament surgery, *ANTERIOR cruciate ligament, *ARTHROSCOPY, *AVULSION fractures, *ACCIDENTAL falls, *FRACTURE fixation, *JOINT hypermobility, *SURGICAL complications, *TIBIA injuries, *TIME, *TRAFFIC accidents, *TREATMENT effectiveness, *COMMINUTED fractures
Abstract

Background: The attachment of the posterior cruciate ligament to the posterior intercondylar fossa of the tibia is in a location that is difficult to access for arthroscopic surgical procedures. This report presents a variety of arthroscopically assisted reduction and fixation methods for managing avulsion fractures of the posterior cruciate ligament from the tibia.Methods: Thirteen patients (fourteen knees) who had an avulsion fracture of the posterior cruciate ligament were treated with an arthroscopic procedure. Eleven patients underwent the operation in the acute phase (four to ten days after the injury), and two patients had delayed surgery (at nineteen and twenty months after the injury) because of nonunion. The choice of fixation method was based on the size of the avulsed fragment. Six knees that had a small bone fragment (<10 mm) with comminution were fixed with use of multiple sutures. Two knees that had a small bone fragment without comminution were fixed with 23-gauge wires. Two knees that had a medium-sized fragment (10 to 20 mm) were fixed with Kirschner wires. Four knees that had a large single fragment of bone (>20 mm) that involved the condyles were fixed with one or two cannulated screws.Results: All patients had osseous union as determined on radiographs. Three injured knees in two patients showed limitation of motion after the operation. These patients had been immobilized for two or three months after the surgery because of concomitant fractures. The eleven patients who had undergone the operation in the acute phase, including two in whom postoperative arthrofibrosis had developed, showed no or trace posterior instability following the procedure. However, the two patients in whom the surgery had been delayed had residual grade-I posterior instability. The postoperative side-to-side differences, when measured with use of the KT-2000 arthrometer and posterior stress radiographs, showed better results in the patients in whom the surgery had been performed in the acute phase than in the patients in whom the operation had been delayed.Conclusion: Arthroscopic procedures can be used to treat tibial avulsion fractures of the posterior cruciate ligament. [ABSTRACT FROM AUTHOR]

Published
2001

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