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Objective: The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol]., Methods: Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples., Results: Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level., Conclusions: This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.

Objectives: The aim of this study was to determine whether the environmental exposure to pyrethroids affects semen quality and the level of reproductive hormones in men., Methods: The study population consisted of 334 men who attended the infertility clinic for diagnostic purposes and who had normal semen concentration of 15 to 300 mln/mL. Participants were interviewed and provided a semen sample. The pyrethroids metabolites-3-phenoxybenzoic acid (3PBA), cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (CDCCA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (TDCCA), and cis-2,2-dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA) were analyzed in the urine using a validated gas chromatography ion-trap mass spectrometry method., Results: Urinary pyrethroids metabolites levels were significantly associated with an increase in the percentage of sperm with abnormal morphology and decrease in sperm concentration, the level of testosterone, and computer-aided semen analysis parameters., Conclusions: Environmental pyrethroids exposure may affect semen quality and the level of reproductive hormones.