1. Effects of Twitch Contraction Induced by Magnetic Stimulation on Expression of Skeletal Muscle Fibrosis Related Genes and Limited Range of Motion in Rats.
- Author
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Kiyoko Kubo, Junya Sakamoto, Ayana Honda, Yuichiro Honda, Hideki Kataoka, Jiro Nakano, and Minoru Okita
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FIBROSIS , *ANKLE physiology , *ANIMAL experimentation , *COLLAGEN , *GENES , *RANGE of motion of joints , *MAGNETOTHERAPY , *MUSCLE contraction , *POLYMERASE chain reaction , *PROLINE , *RATS , *RESEARCH funding , *SPINE , *CALF muscles , *TREATMENT effectiveness , *REVERSE transcriptase polymerase chain reaction , *DORSIFLEXION , *THERAPEUTICS - Abstract
Objective: We examined the effects of twitch contraction induced by lumbar spinal root magnetic stimulation on immobilization-induced limited range of motion and skeletal muscle fibrosis in rat soleus muscle. Design: The groups included male Wistar rats (controls), rats with both bilateral ankle joints immobilized with plaster casts for 4 wks (immobilization [IM]), and rats in which twitch contraction of the soleus muscle was induced by lumbar magnetic stimulation for 4 wks of immobilization (twitch contraction [TC]). Group differences in ankle dorsiflexion range of motion, collagen content as determined by hydroxyproline assay, and the expression of fibrosis-related genes as determined by reverse transcription-polymerase chain reaction (hypoxia inducible factor 1α, α-smooth muscle actin, and types I and III collagen) in the soleus muscle were examined after the 4-wk-long experiment. Results: Range of motion in the TC group was significantly greater than that in the IM group. The hydroxyproline content and the expressions of fibrosis-related genes decreased significantly in the TC group compared with those in the IM group. No significant differences were seen in the expression of transforming growth factor β mRNA. Conclusions: These results suggest that twitch contraction induced by lumbar spinal root magnetic stimulation may reduce immobilization induced limited range of motion and skeletal muscle fibrosis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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