1. Cardiovascular Protection Beyond Blood Pressure-Lowering Redux: The ACCOMPLISH trial.
- Author
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Kaciroti, Niko, Jamerson, Kenneth A., and Brook, Robert D.
- Abstract
The article discusses the results of the ACCOMPLISH trial, which aimed to determine the cardiovascular benefits of different antihypertensive medications. The trial found that starting treatment with a combination of a renin-angiotensin system inhibitor (benazepril) and a calcium channel blocker (amlodipine) reduced cardiovascular events by 20% compared to a thiazide diuretic (hydrochlorothiazide), despite minimal differences in blood pressure. The study suggests that the cardiovascular benefits of the combination therapy are likely due to BP-independent pathways, such as pleiotropic actions and other clinical benefits. The findings support the use of renin-angiotensin system inhibitors and calcium channel blockers as initial therapy for hypertension. [Extracted from the article]
- Published
- 2024
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