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Your search keyword '"Insulin cerebrospinal fluid"' showing total 4 results
Start Over Descriptor "Insulin cerebrospinal fluid" Publisher lippincott williams & wilkins
4 results on '"Insulin cerebrospinal fluid"'

1. Insulin and Alzheimer's disease: an amyloid connection.

Author

Galasko D

Subjects
Aged, Aging metabolism, Alzheimer Disease metabolism, Amyloid beta-Peptides cerebrospinal fluid, Diabetes Mellitus metabolism, Humans, Insulin cerebrospinal fluid, Insulin pharmacology, Memory drug effects, Models, Biological, Peptide Fragments cerebrospinal fluid, Solubility, Alzheimer Disease etiology, Amyloid beta-Peptides metabolism, Diabetes Complications, Insulin metabolism
Published
2003
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2. Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.

Author

Gurwitz D, Chapman J, and Weizman A

Subjects
Age of Onset, Alzheimer Disease genetics, Alzheimer Disease metabolism, Apolipoprotein E4, Brain metabolism, Disease Progression, Head blood supply, Humans, Insulin blood, Insulin cerebrospinal fluid, Insulin-Like Growth Factor I metabolism, Risk Factors, Alzheimer Disease etiology, Anthropometry, Apolipoproteins E genetics, Head anatomy & histology
Published
2002
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3. Insulin, diabetes mellitus, Alzheimer's disease, and apolipoprotein E.

Author

Gambassi G and Bernabei R

Subjects
Alzheimer Disease genetics, Alzheimer Disease metabolism, Blood Glucose metabolism, Brain metabolism, Diabetes Mellitus genetics, Diabetes Mellitus metabolism, Humans, Insulin blood, Insulin cerebrospinal fluid, Alzheimer Disease physiopathology, Apolipoproteins E genetics, Diabetes Mellitus physiopathology, Insulin metabolism
Published
1998
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4. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

Author

Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, and Porte D Jr

Subjects
Aged, Alzheimer Disease genetics, Apolipoprotein E4, Homozygote, Humans, Middle Aged, Alzheimer Disease blood, Alzheimer Disease cerebrospinal fluid, Apolipoproteins E genetics, Insulin blood, Insulin cerebrospinal fluid
Abstract

Patients with Alzheimer's disease (AD) have elevations of fasting plasma insulin that are hypothesized to be associated with disrupted brain insulin metabolism. We examined paired fasted plasma and CSF insulin levels in 25 patients with AD and 14 healthy age-matched adults and determined whether insulin levels were related to severity of dementia and apolipoprotein E-epsilon4 homozygosity, a known genetic risk factor for AD. The AD patients had lower CSF insulin, higher plasma insulin, and a reduced CSF-to-plasma insulin ratio when compared with healthy adults. The differences were greater for patients with more advanced AD. Patients who were not apolipoprotein E-epsilon4 homozygotes had higher plasma insulin levels and reduced CSF-to-plasma ratios, whereas epsilon4 homozygotes with AD had normal values. Both plasma and CSF insulin levels are abnormal in AD, and there are metabolic differences among apolipoprotein E genotypes.

Published
1998
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