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16 results on '"Escalard, Simon"'

3. Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19

Author

Escalard, Simon, Maïer, Benjamin, Redjem, Hocine, Delvoye, François, Hébert, Solène, Smajda, Stanislas, Ciccio, Gabriele, Desilles, Jean-Philippe, Mazighi, Mikael, Blanc, Raphael, and Piotin, Michel

Subjects
Male, Pneumonia, Viral, Arterial Occlusive Diseases, Brain Ischemia, Time-to-Treatment, Plasminogen Activators, coagulation disorder, Humans, Thrombolytic Therapy, Hospital Mortality, Pandemics, Aged, Thrombectomy, outbreak, Brief Report, COVID-19, Brain, Blood Coagulation Disorders, Cerebral Arteries, Middle Aged, stroke, Cerebral Veins, Treatment Outcome, Tissue Plasminogen Activator, Female, Coronavirus Infections
Abstract

Background and Purpose: Higher rates of strokes have been observed in patients with coronavirus disease 2019 (COVID-19), but data regarding the outcomes of COVID-19 patients suffering from acute ischemic stroke due to large vessel occlusion (LVO) are lacking. We report our initial experience in the treatment of acute ischemic stroke with LVO in patients with COVID-19. Methods: All consecutive patients with COVID-19 with acute ischemic stroke due to LVO treated in our institution during the 6 first weeks of the COVID-19 outbreak were included. Baseline clinical and radiological findings, treatment, and short-term outcomes are reported. Results: We identified 10 patients with confirmed COVID-19 treated for an acute ischemic stroke due to LVO. Eight were men, with a median age of 59.5 years. Seven had none or mild symptoms of COVID-19 at stroke onset. Median time from COVID-19 symptoms to stroke onset was 6 days. All patients had brain imaging within 3 hours from symptoms onset. Five patients had multi-territory LVO. Five received intravenous alteplase. All patients had mechanical thrombectomy. Nine patients achieved successful recanalization (mTICI2B-3), none experienced early neurological improvement, 4 had early cerebral reocclusion, and a total of 6 patients (60%) died in the hospital. Conclusions: Best medical care including early intravenous thrombolysis, and successful and prompt recanalization achieved with mechanical thrombectomy, resulted in poor outcomes in patients with COVID-19. Although our results require further confirmation, a different pharmacological approach (antiplatelet or other) should be investigated to take in account inflammatory and coagulation disorders associated with COVID-19.

Published
2020

4. Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial.

Author

Anadani, Mohammad, Maier, Benjamin, Escalard, Simon, Labreuche, Julien T, de Havenon, Adam, Sabben, Candice, Lapergue, Bertrand, Gory, Benjamin, Richard, Sebastien, Sibon, Igor, Desilles, Jean-Philippe, Blanc, Raphael, Piotin, Michel, Mazighi, Mikael, of, behalf the BP-TARGET Study Group, Maïer, Benjamin, Labreuche, Julien, and of behalf the BP-TARGET Study Group*

Published
2022
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5. Association of Hypotension During Thrombectomy and Outcomes Differs With the Posterior Communicating Artery Patency.

Author

Maïer, Benjamin, Robichon, Erwan, Bourcier, Romain, Dargazanli, Cyril, Labreuche, Julien, Thion, Laurie-Anne, Leguen, Morgan, Riem, Romuald, Desilles, Jean-Philippe, Boulouis, Grégoire, Delvoye, François, Hebert, Solène, Redjem, Hocine, Smajda, Stanislas, Escalard, Simon, Blanc, Raphaël, Piotin, Michel, Lapergue, Bertrand, Mazighi, Mikael, and ASTER Trial†

Published
2021
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6. Effect of Operator's Experience on Proficiency in Mechanical Thrombectomy: A Multicenter Study.

Author

Zhu, François, Hassen, Wagih Ben, Bricout, Nicolas, Kerleroux, Basile, Janot, Kevin, Gory, Benjamin, Anxionnat, René, Richard, Sébastien, Marchal, Adrien, Blanc, Raphael, Piotin, Michel, Consoli, Arturo, Trystram, Denis, Regent, Christine Rodriguez, Desilles, Jean-Philippe, Weisenburger-Lile, David, Escalard, Simon, Herbreteau, Denis, Ifergan, Heloise, and Maldonado, Igor Lima

Published
2021
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7. European Multicenter Study of ET-COVID-19.

Author

Cagnazzo, Federico, Piotin, Michel, Escalard, Simon, Maier, Benjamin, Ribo, Marc, Requena, Manuel, Pop, Raoul, Hasiu, Anca, Gasparotti, Roberto, Mardighian, Dikran, Piano, Mariangela, Cervo, Amedeo, Eker, Omer Faruk, Durous, Vincent, Sourour, Nader-Antoine, Elhorany, Mahmoud, Zini, Andrea, Simonetti, Luigi, Marcheselli, Simona, and Paolo, Nuzzi Nunzio

Published
2021
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9. Effect of Steady and Dynamic Blood Pressure Parameters During Thrombectomy According to the Collateral Status.

Author

Maïer, Benjamin, Dargazanli, Cyril, Bourcier, Romain, Kyheng, Maëva, Labreuche, Julien, Mosimann, Pascal J., Puccinelli, Francesco, Taylor, Guillaume, Le Guen, Morgan, Riem, Romuald, Desilles, Jean-Philippe, Boisseau, William, Fahed, Robert, Redjem, Hocine, Smajda, Stanislas, Ciccio, Gabriele, Escalard, Simon, Blanc, Raphaël, Piotin, Michel, and Lapergue, Betrand

Published
2020
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10. Impact of Reperfusion for Nonagenarians Treated by Mechanical Thrombectomy: Insights From the ETIS Registry.

Author

Drouard-de Rousiers, Eve, Lucas, Ludovic, Richard, Sébastien, Consoli, Arturo, Mazighi, Mikaël, Labreuche, Julien, Kyheng, Maéva, Gory, Benjamin, Dargazanli, Cyril, Arquizan, Caroline, Marnat, Gaultier, Blanc, Raphaël, Desal, Hubert, Bourcier, Romain, Sibon, Igor, Lapergue, Bertrand, Piotin, Michel, Redjem, Hocine, Escalard, Simon, and Desilles, Jean-Philippe

Published
2019
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12. Neutrophil count predicts poor outcome despite recanalization after endovascular therapy.

Author

Boisseau, William MD, Desilles, Jean-Philippe MD, PhD, Fahed, Robert MD, Kyheng, Maeva MSc, Zuber, Kevin MSc, Sabben, Candice MD, Taylor, Guillaume MD, Ben Maacha, Malek MSc, Maier, Benjamin MD, Botta, Daniele MD, Escalard, Simon MD, Ciccio, Gabriele MD, Smajda, Stanislas MD, Redjem, Hocine MD, Piotin, Michel MD, PhD, Mazighi, Mikael MD, PhD, Blanc, Raphael MD, MSc, Boisseau, William, Desilles, Jean-Philippe, and Fahed, Robert

Published
2019
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13. Acute Stroke With Large Ischemic Core Treated by Thrombectomy.

Author

Panni, Pietro, Gory, Benjamin, Xie, Yu, Consoli, Arturo, Desilles, Jean-Philippe, Mazighi, Mikael, Labreuche, Julien, Piotin, Michel, Turjman, Francis, Eker, Omer Faruk, Bracard, Serge, Anxionnat, René, Richard, Sébastien, Hossu, Gabriela, Blanc, Raphael, Lapergue, Bertrand, Redjem, Hocine, Escalard, Simon, Ciccio, Gabriele, and Smajda, Stanislas

Published
2019
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15. Outcome of Aneurysmal Subarachnoid Hemorrhage Not Altered With Transatlantic Airplane Transfer: A Bicentric Matched Case-control Study.

Author

Martino F, Trainel M, Guillaume J, Schaffar A, Escalard S, Pons A, and Engrand N

Abstract

Objective: It is recommended that ruptured cerebral aneurysms are treated in a high-volume center within 72 hours of ictus. We assessed the impact of long-distance aeromedical evacuation in patients presenting aSAH., Methods: This case-control study compared patients with aneurysmal subarachnoid hemorrhage (aSAH) who had a 6750 km air transfer from Guadeloupe (a Caribbean island) to Paris, France, for neurointerventional management in a tertiary center with a matched cohort from Paris region treated in the same center over a 10-year period (2010 to 2019). The 2 populations were matched on age, sex, World Federation of Neurological Surgeons score, and Fisher score. The primary outcome was a 1-year modified Rankin Scale score ≤3. Secondary outcomes included time from diagnosis to securing aneurysm, 1-year mortality, and a cost analysis., Results: Among 128 consecutive aSAH transferred from Guadeloupe, 93 were matched with 93 patients from the Paris area. The proportion of patients with 1-year modified Rankin Scale ≤3 (75% vs 82%, respectively; P= 0.5) and 1-year mortality (18% vs 14%, respectively; P= 0.2) was similar in the Guadeloupe and Paris groups. The median (interquartile range: Q1, Q3) time from diagnosis to securing the aneurysm was higher in the patients from Guadeloupe than those from Paris (48 [30, 63] h vs 23 [12, 24] h, respectively; P< 0.001). Guadeloupean patients received mechanical ventilation (58% vs 38%; P< 0.001) and external ventricular drainage (55% vs 39%; P= 0.005) more often than those from Paris. The additional cost of treating a Guadeloupe patient in Paris was estimated at 7580 Euros or 17% of the estimated cost in Guadeloupe., Conclusions: Long-distance aeromedical evacuation of patients with aSAH from Guadeloupe to Paris resulted in a 25-hour increase in time to aneurysm coiling embolization time but did not impact 1-year functional outcomes or mortality., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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16. Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak: Decreased Activity, and Increased Care Delays.

Author

Kerleroux B, Fabacher T, Bricout N, Moïse M, Testud B, Vingadassalom S, Ifergan H, Janot K, Consoli A, Ben Hassen W, Shotar E, Ognard J, Charbonnier G, L'Allinec V, Guédon A, Bolognini F, Marnat G, Forestier G, Rouchaud A, Pop R, Raynaud N, Zhu F, Cortese J, Chalumeau V, Berge J, Escalard S, and Boulouis G

Subjects
Aged, Aged, 80 and over, Brain Ischemia epidemiology, COVID-19, Female, France epidemiology, Hospitalization statistics & numerical data, Humans, Male, Mechanical Thrombolysis methods, Middle Aged, Patient Admission statistics & numerical data, Procedures and Techniques Utilization, Prospective Studies, SARS-CoV-2, Stroke epidemiology, Time-to-Treatment statistics & numerical data, Betacoronavirus, Brain Ischemia surgery, Coronavirus Infections, Delivery of Health Care, Mechanical Thrombolysis statistics & numerical data, Pandemics, Pneumonia, Viral, Stroke surgery
Abstract

Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT)., Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value)., Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76-0.82]; P <0.001) in MT case volumes during the epidemic period, and a significant increase in delays between imaging and groin puncture, overall (mean 144.9±SD 86.8 minutes versus 126.2±70.9; P <0.001 in 2019) and in transferred patients (mean 182.6±SD 82.0 minutes versus 153.25±67; P <0.001). After the instatement of strict epidemic mitigation measures, there was a significant negative correlation between the number of hospitalizations for COVID and the number of MT cases ( R 2 -0.51; P =0.04). Patients treated during the COVID outbreak were less likely to receive intravenous thrombolysis and to have unwitnessed strokes (both P <0.05)., Conclusions: Our study showed a significant decrease in patients treated with MTs during the first stages of the COVID epidemic in France and alarming indicators of lengthened care delays. These findings prompt immediate consideration of local and regional stroke networks preparedness in the varying contexts of COVID-19 pandemic evolution.

Published
2020
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