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Your search keyword '"Culley, Deborah J."' showing total 142 results
Start Over Author "Culley, Deborah J." Publisher lippincott williams & wilkins
142 results on '"Culley, Deborah J."'

3. Odor Enrichment Attenuates the Anesthesia/Surgery-induced Cognitive Impairment.

Author

Zhang, Ce, Han, Yuan, Liu, Xiaojun, Tan, Hong, Dong, Yuanlin, Zhang, Yiying, Liang, Feng, Zheng, Hui, Crosby, Gregory, Culley, Deborah J., Marcantonio, Edward R., Shen, Yuan, Cao, Jun-Li, and Xie, Zhongcong

Abstract

Objective: To determine the association between olfactory function and cognition in patients and rodents. Background: Perioperative neurocognitive disorders include delayed neurocognitive recovery (dNCR). The contribution of olfactory function to dNCR remains undetermined. It is unknown whether odor enrichment could mitigate dNCR. Methods: We performed a prospective observational cohort study to determine potential association between olfactory impairment and dNCR in patients. We assessed the effects of anesthesia/surgery on olfactory and cognitive function in mice using the block test and Barnes maze. We measured interleukin-6 (IL-6), olfactory mature protein, growth-associated protein 43, mature and premature olfactory neurons, postsynaptic density 95, and synaptophysin in blood, nasal epithelium, and hippocampus of mice. Odor enrichment, IL-6 antibody, and knockout of IL-6 were used in the interaction experiments. Results: Patients with dNCR had worse odor identification than the patients without dNCR [preoperative: 7 (1.25, 9) vs 10 (8, 11), median (interquartile range), P <0.001; postoperative: 8 (2.25, 10) vs 10 (8, 11), P <0.001]. Olfactory impairment associated with dNCR in patients before and after adjusting age, sex, education, preoperative mini-mental state examination score, and days of the neuropsychological tests. Anesthesia/surgery induced olfactory and cognitive impairment, increased levels of IL-6 in blood and nasal epithelium, decreased amounts of olfactory receptor neurons and their markers in the nasal epithelium, and reduced amounts of synapse markers in the hippocampus of mice. These changes were attenuated by odor enrichment and IL-6 antibody. Conclusion: The anesthesia/surgery-induced olfactory impairment may contribute to dNCR in patients and postoperative cognitive impairment in mice. Odor enrichment could be a potential intervention. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group.

Author

Berger, Miles, Schenning, Katie J., Brown IV, Charles H., Deiner, Stacie G., Whittington, Robert A., Eckenhoff, Roderic G., Angst, Martin S., Avramescu, Sinziana, Bekker, Alex, Brzezinski, Marek, Crosby, Greg, Culley, Deborah J., Eckenhoff, Maryellen, Eriksson, Lars I., Evered, Lis, Ibinson, Jim, Kline, Richard P., Kofke, Andy, Ma, Daqing, and Mathew, Joseph P.

Published
2018
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23. Simulation-based Assessment to Reliably Identify Key Resident Performance Attributes.

Author

Blum, Richard H., Muret-Wagstaff, Sharon L., Boulet, John R., Cooper, Jeffrey B., Petrusa, Emil R., Baker, Keith H, Davidyuk, Galina, Dearden, Jennifer L, Feinstein, David M, Jones, Stephanie B, Kimball, William R, Mitchell, John D, Nadelberg, Robert L, Wiser, Sarah H, Albrecht, Meredith A, Anastasi, Amanda K, Bose, Ruma R, Chang, Laura Y, Culley, Deborah J, and Fisher, Lauren J

Published
2018
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24. Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients.

Author

Culley, Deborah J., Flaherty, Devon, Fahey, Margaret C., Rudolph, James L., Javedan, Houman, Chuan-Chin Huang, Wright, John, Bader, Angela M., Hyman, Bradley T., Blacker, Deborah, Crosby, Gregory, and Huang, Chuan-Chin

Subjects
*COGNITION disorders diagnosis, *DIAGNOSIS of delirium, *AGE distribution, *CLINICAL trials, *COGNITION disorders, *COMPARATIVE studies, *DELIRIUM, *LENGTH of stay in hospitals, *LONGITUDINAL method, *NEUROPSYCHOLOGICAL tests, *RESEARCH methodology, *MEDICAL cooperation, *ORTHOPEDIC surgery, *PREOPERATIVE care, *RESEARCH, *RESEARCH funding, *EVALUATION research, *PREDICTIVE tests, *SURGICAL complications, *PSYCHOLOGICAL factors, *DIAGNOSIS, *PSYCHOLOGY
Abstract

Background: The American College of Surgeons and the American Geriatrics Society have suggested that preoperative cognitive screening should be performed in older surgical patients. We hypothesized that unrecognized cognitive impairment in patients without a history of dementia is a risk factor for development of postoperative complications.Methods: We enrolled 211 patients 65 yr of age or older without a diagnosis of dementia who were scheduled for an elective hip or knee replacement. Patients were cognitively screened preoperatively using the Mini-Cog and demographic, medical, functional, and emotional/social data were gathered using standard instruments or review of the medical record. Outcomes included discharge to place other than home (primary outcome), delirium, in-hospital medical complications, hospital length-of-stay, 30-day emergency room visits, and mortality. Data were analyzed using univariate and multivariate analyses.Results: Fifty of 211 (24%) patients screened positive for probable cognitive impairment (Mini-Cog less than or equal to 2). On age-adjusted multivariate analysis, patients with a Mini-Cog score less than or equal to 2 were more likely to be discharged to a place other than home (67% vs. 34%; odds ratio = 3.88, 95% CI = 1.58 to 9.55), develop postoperative delirium (21% vs. 7%; odds ratio = 4.52, 95% CI = 1.30 to 15.68), and have a longer hospital length of stay (hazard ratio = 0.63, 95% CI = 0.42 to 0.95) compared to those with a Mini-Cog score greater than 2.Conclusions: Many older elective orthopedic surgical patients have probable cognitive impairment preoperatively. Such impairment is associated with development of delirium postoperatively, a longer hospital stay, and lower likelihood of going home upon hospital discharge. [ABSTRACT FROM AUTHOR]

Published
2017
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37. As We Heal the Body, Do We Harm the Brain?

Author

Culley, Deborah J.

Subjects
*DELIRIUM, *COGNITION disorders, *DISEASES in older people, *DEMENTIA, *BRAIN diseases
Abstract

The article focuses on delirium and prolonged postoperative cognitive dysfunction, which are seen as the most common forms of perioperative morbidity in elders, affecting 8-74% of them. Delirium is defined as an acute brain disorder characterized in part by an altered level of consciousness, distorted environmental awareness, and a change in cognition or the development of perceptual disturbances that are not the result of a preexisting dementia.

Published
2010
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45. In Response.

Author

Berger, Miles, Angst, Martin S., Culley, Deborah J., Price, Catherine E., Scott, David A., Whittington, Robert A., and Eckenhoff, Roderic G.

Published
2019
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48. At the Sharp End of Spines.

Author

Crosby, Gregory, Culley, Deborah J., and Patel, Piyush M.

Subjects
*SIDE effects of anesthetics, *POSTPARTUM depression, *APOPTOSIS, *NEURONS
Abstract

The authors reflect on the study by A. Briner and colleagues regarding the vulnerability of developing brain to anesthetics. The authors say that based from animal studies, it is possible for cognitive and social behavior deficiency when expose to anesthetics during postnatal period. The author also compare the study by Briner to the study by B. P. Head and colleagues which shows that anesthetics exposure leads to neuroapoptosis.

Published
2010
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