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2 results on '"Cohen, Jeffrey"'

1. Recommendations for observational studies of comorbidity in multiple sclerosis

Author

Marrie, Ruth Ann, Miller, Aaron, Sormani, Maria Pia, Thompson, Alan, Waubant, Emmanuelle, Trojano, Maria, O'Connor, Paul, Fiest, Kirsten, Reider, Nadia, Reingold, Stephen, and Cohen, Jeffrey A.

Subjects
Multiple sclerosis, Medical/Systematic disease, Epidemiology, 3. Good health
Abstract

Objective:To reach consensus about the most relevant comorbidities to study in multiple sclerosis (MS) with respect to incidence, prevalence, and effect on outcomes; review datasets that may support studies of comorbidity in MS; and identify MS outcomes that should be prioritized in such studies.Methods:We held an international workshop to meet these objectives, informed by a systematic review of the incidence and prevalence of comorbidity in MS, and an international survey regarding research priorities for comorbidity.Results:We recommend establishing age- and sex-specific incidence and prevalence estimates for 5 comorbidities (depression, anxiety, hypertension, hyperlipidemia, and diabetes); evaluating the effect of 7 comorbidities (depression, anxiety, hypertension, diabetes, hyperlipidemia, chronic lung disease, and autoimmune diseases) on disability, quality of life, brain atrophy and other imaging parameters, health care utilization, employment, and mortality, including age, sex, race/ethnicity, socioeconomic status, and disease duration as potential confounders; harmonizing study designs across jurisdictions; and conducting such studies worldwide. Ultimately, clinical trials of treating comorbidity in MS are needed.Conclusion:Our recommendations will help address knowledge gaps regarding the incidence, prevalence, and effect of comorbidity on outcomes in MS.

2. Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

Author

Kaho B. Onomichi, Anna Tomczak, Allyson Reid, Ilya Kister, Jacinta M. Behne, Megan Kenneally Behne, Claire S Riley, Leticia Tornes, Julia J. Schubert, Jeffrey A. Cohen, Michael J. Levy, Devin S. Mullin, Jeffrey Bennett, Lawrence J. Cook, Renee R. Rodriguez, Terrence F. Blaschke, Zoe Rimler, Anthony Traboulsee, Jessica S. Alvey, Casey Engel, Derek W. Blackway, Anne Rumpf, Libby Levine, Anna Marie Jolley, Jennifer L. Sedlak, Ruth Johnson, Tanuja Chitnis, Katrina McMullen, Nancy Nealon, Brie Marron, Renee Kuhn, Mason Kruse-Hoyer, Brian Coords, Andrew W. Russo, Angela Greer, Stephen McKechnie, Terry J. Smith, Sarah M. Planchon, Melanie Marcille, Lilyana Amezcua, F. Rene Enriquez, Michael R. Yeaman, Pavle Repovic, Maureen A. Mealy, Ilana Katz Sand, Jeff Yearley, Erika Amundson, May H. Han, Lisa Eunyoung Lee, John W. Rose, Melissa Pederson, Daniel W. Behne, Robert Carruthers, Katherine E. Nelson, Ana Pruitt, Jessica Coleman, Eric C. Klawiter, Judy Sheard, Diane Ivancic, Nancy L. Sicotte, Myka Barnes-Garcia, İÜC, Neurology, Ayşe Altıntaş ( ORCID 0000-0002-8524-5087 & YÖK ID 11611), Cook, Lawrence J., Rose, John W., Alvey, Jessica S., Jolley, Anna Marie, Kuhn, Renee, Marron, Brie, Pederson, Melissa, Enriquez, Rene, Yearley, Jeff, McKechnie, Stephen, Han, May H., Tomczak, Anna J., Levy, Michael, Mealy, Maureen A., Coleman, Jessica, Bennett, Jeffrey L., Johnson, Ruth, Barnes-Garcia, Myka, Traboulsee, Anthony L., Carruthers, Robert L., Lee, Lisa Eunyoung, Schubert, Julia J., McMullen, Katrina, Kister, Ilya, Rimler, Zoe, Reid, Allyson, Sicotte, Nancy L., Planchon, Sarah M., Cohen, Jeffrey A., Ivancic, Diane, Sedlak, Jennifer L., Sand, Ilana Katz, Repovic, Pavle, Amezcua, Lilyana, Pruitt, Ana, Amundson, Erika, Chitnis, Tanuja, Mullin, Devin S., Klawiter, Eric C., Russo, Andrew W., Riley, Claire S., Onomichi, Kaho B., Levine, Libby, Nelson, Katherine E., Nealon, Nancy M., Engel, Casey, Kruse-Hoyer, Mason, Marcille, Melanie, Tornes, Leticia, Rumpf, Anne, Greer, Angela, Behne, Megan Kenneally, Rodriguez, Renee R., Behne, Daniel W., Blackway, Derek W., Coords, Brian, Blaschke, Terrence F., Sheard, Judy, Smith, Terry J., Behne, Jacinta M., Yeaman, Michael R., Abboud, Hesham, Aktas, Orhan, Altintas, Ayse, Apiwattanakul, Metha, Asgari, Nasrin, Banwell, Brenda, Bichuetti, Denis, Bowen, James, Broadley, Simon, Bruck, Wolfgang, Cabre, Philippe, Cohen, Jeffrey, De Seze, Jerome, Delgado-Garcia, Guillermo, Basuroski, Irena Dujmovic, Fujihara, Kazuo, Goodman, Andrew, Havla, Joachim, Hellwig, Kerstin, Hintzen, Rogier, Hooper, D. Craig, Iorio, Raffaele, Jacob, Anu, Jarius, Sven, Jimenez Arango, Jorge Andres, John, Gareth, Kim, Ho Jin, Kim, Sung Min, Kimbrough, Dorian J., Kissani, Najib, Kleiter, Ingo, Lana-Peixoto, Marco, Leite, M. Isabel, Liu, Yaou, Lublin, Fred, Maiga, Youssoufa, Mao-Draayer, Yang, Marignier, Romain, Matiello, Marcelo, Momtazee, Callene, Morrow, Mark, Nakashima, Ichiro, O'Connor, Kevin, Oreja-Guevara, Celia, Palace, Jacqueline, Pandit, Lekha, Paul, Friedemann, Prayoonwiwat, Naraporn, Probstel, Anne-Katrin, Qian, Peiqing, Quan, Chao, Ringelstein, Marius, Rivera, Victor, Rotstein, Dalia L., Ruprecht, Klemens, Sa, Maria Jose, Saiz, Albert, Serguera, Che, Shosha, Eslam, Siritho, Sasitorn, Siva, Aksel, Soto de Castillo, Ibis, Stuve, Olaf, Tenembaum, Silvia, Villoslada, Pablo, Wingerchuk, Dean, Wuerfel, Jens, Yeh, E. Ann, Zamvil, Scott S., Langer-Gould, Annette, School of Medicine, and Department of Neurology

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pediatrics, Biomedical Research, Internationality, MEDLINE, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, Spectrum disorder, Longitudinal Studies, Intersectoral Collaboration, International research, Neuromyelitis optica, business.industry, Neuromyelitis Optica, Middle Aged, medicine.disease, 3. Good health, 030104 developmental biology, Neurology, Cohort, Medicine, Clinical neurology, Neurosciences, Female, Observational study, Neurology (clinical), Function and Dysfunction of the Nervous System, business, 030217 neurology & neurosurgery, Neuromyelitis-optica, Diagnostic-criteria, Prevalence, Multicenter, Disorders, Features, Cohort study
Abstract

Objective to develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. Methods to illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. Results as of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. Conclusions collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD., The Guthy-Jackson Charitable Foundation, The CIRCLES Project

Published
2019

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