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Your search keyword '"Bolton‐Moore, Carolyn"' showing total 14 results
Start Over Author "Bolton‐Moore, Carolyn" Publisher lippincott williams & wilkins
14 results on '"Bolton‐Moore, Carolyn"'

5. Differentiated Care Preferences of Stable Patients on Antiretroviral Therapy in Zambia: A Discrete Choice Experiment.

Author

Eshun-Wilson, Ingrid, Mukumbwa-Mwenechanya, Mpande, Kim, Hae-Young, Zannolini, Arianna, Mwamba, Chanda P., Dowdy, David, Kalunkumya, Estella, Lumpa, Mwansa, Beres, Laura K., Roy, Monika, Sharma, Anjali, Topp, Steph M., Glidden, Dave V., Padian, Nancy, Ehrenkranz, Peter, Sikazwe, Izukanji, Holmes, Charles B., Bolton-Moore, Carolyn, and Geng, Elvin H.

Published
2019
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6. CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection.

Author

Moore, Carolyn Bolton, Capparelli, Edmund V., Samson, Pearl, Bwakura-Dangarembizi, Mutsa, Jean-Philippe, Patrick, Worrell, Carol, Heckman, Barbara, Purdue, Lynette, Spector, Stephen A., Benns, Alex, Borkowsky, William, Loftis, Amy, Hawkins, Elizabeth, Wallis, Carole, Chadwick, Ellen G., IMPAACT P1070 team, and Bolton Moore, Carolyn

Published
2017
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14. CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection.

Author

Bolton Moore C, Capparelli EV, Samson P, Bwakura-Dangarembizi M, Jean-Philippe P, Worrell C, Heckman B, Purdue L, Spector SA, Benns A, Borkowsky W, Loftis A, Hawkins E, Wallis C, and Chadwick EG

Subjects
Alkynes, Child, Preschool, Cyclopropanes, Female, Humans, Infant, Male, Prospective Studies, Benzoxazines administration & dosage, Benzoxazines pharmacokinetics, Cytochrome P-450 CYP2B6 genetics, Genotype, HIV Infections drug therapy, Reverse Transcriptase Inhibitors administration & dosage, Reverse Transcriptase Inhibitors pharmacokinetics
Abstract

Objectives: To determine safety-specific, efficacy-specific and genotypic-specific dose requirements of efavirenz (EFV) in children aged 3 to less than 36 months with HIV infection., Design: IMPAACT P1070 was a 24-week prospective cohort trial of EFV (as open capsules) and two nucleoside reverse transcriptase inhibitors in children with HIV infection 3 to less than 36 months without tuberculosis (Cohort 1)., Methods: CYP2B6 G516T genotype was determined, and intensive pharmacokinetics was performed at week 2. EFV dose was adjusted if outside the target area under the curve (AUC) 35-180 μg*h/ml. Pharmacokinetic and CYP2B6 G516T genotype data were used to model EFV exposures based on Food and Drug Administration (FDA)-approved doses., Results: Forty-seven participants, median age 19 months, initiated the study regimen with 24 weeks median follow-up; 38 516GG/GT and 9 516TT genotypes. Initially, median EFV AUC was higher in 516TT vs. 516GG/GT (median 490 vs. 107 μg*h/ml; P = 0.0001) with all 516TT above AUC target. Following an amendment that reduced the 516TT EFV dose by 75%, pharmacokinetic modeling predicted that 83% of participants met the AUC target (31/38 516GG/GT, 8/9 516TT). In contrast, modeling using P1070 data predicted that FDA-approved doses would produce subtherapeutic AUCs in almost one-third of participants with 516GG/GT and excessive AUCs in more than 50% with 516TT genotypes., Conclusion: CYP2B6 G516T genotype strongly influences EFV exposures in this age group. Genotype-directed dosing yields therapeutic EFV concentrations and appears to outperform other dosing approaches.

Published
2017
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