1. Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801.
- Author
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Fumagalli F, Molteni R, Bedogni F, Gennarelli M, Perez J, Racagni G, and Riva MA
- Subjects
- Animals, Brain anatomy & histology, Brain drug effects, Brain metabolism, Brain-Derived Neurotrophic Factor genetics, Drug Interactions, Fibroblast Growth Factor 2 genetics, Genes, fos physiology, Hippocampus metabolism, Male, Quetiapine Fumarate, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Antipsychotic Agents pharmacology, Brain-Derived Neurotrophic Factor metabolism, Dibenzothiazepines pharmacology, Dizocilpine Maleate pharmacology, Excitatory Amino Acid Antagonists pharmacology, Fibroblast Growth Factor 2 metabolism, Gene Expression Regulation drug effects, Hippocampus drug effects
- Abstract
Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.
- Published
- 2004
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