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Your search keyword '"Trylesinski, Aldo"' showing total 2 results
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2. Risk factors for CD4 lymphopenia in patients treated with a tenofovir/didanosine high dose-containing highly active antiretroviral therapy regimen.

Author

Lacombe K, Pacanowski J, Meynard JL, Trylesinski A, and Girard PM

Subjects
Adenine adverse effects, Adult, Antiretroviral Therapy, Highly Active adverse effects, CD4 Lymphocyte Count, Female, Humans, Male, Risk Factors, Tenofovir, Adenine analogs & derivatives, Anti-HIV Agents adverse effects, CD4-Positive T-Lymphocytes, Didanosine adverse effects, HIV Infections drug therapy, Lymphopenia chemically induced, Organophosphonates adverse effects
Abstract

In this study, the dynamics of CD4 cell depletion during tenofovir/didanosine co-administration were analysed. Ninety-five HIV-positive patients were followed for 562 days, and 37 lost at least 50 CD4 cells, with a median delay of 274 days. Cox analysis showed that the CD4 cell decrease was associated with a duration of treatment by didanosine of more than 853 days and a didanosine dose of more than 5.50 mg/kg.

Published
2005
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