1. Assessment of laser Doppler perfusion imager’sin vivoreliability: Can it be used for a prospective analysis?
- Author
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Chirag Shah, Damanpreet Singh Bedi, Aristidis Veves, Antonella Caselli, and Colleen O’Connor
- Subjects
Materials science ,Laser scanning ,Biomedical Engineering ,Blood flow ,Laser Doppler velocimetry ,Laser ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Microcirculation ,law.invention ,medicine.anatomical_structure ,Forearm ,law ,Cuff ,medicine ,Instrumentation ,Perfusion ,Biomedical engineering - Abstract
The aim of this study was to assess the reliability of the laser Doppler perfusion imager (Lisca PIM 1.0; Lisca development, Linkoping, Sweden) for longitudinal analysis. We measured the skin blood flow under a biological zero condition at the forearm level in 84 patients enrolled in a 12 week prospective interventional trial. Since the biological zero is the background reading registered by the laser when blood flow has been occluded, any fluctuation of the measurements obtained under this condition can be attributable to the laser scanner’s variability rather than biological variation. After the blood flow of the arm was occluded and arrested by a pressure cuff, blood perfusion readings were taken before and after the iontophoresis of a 1% acetylcholine chloride solution and a 1% sodium nitroprusside solution at the beginning of the study and during the two follow-up visits. A total of 927 biological zero readings were recorded throughout the study. The coefficient of variation of these measurements was...
- Published
- 2002
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