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1. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study.

Author

Castaigne, Sylvie, Pautas, Cécile, Terré, Christine, Raffoux, Emmanuel, Bardessoule, Dominique, Bastie, Jean-Noel, Legrand, Ollivier, Thomas, Xavier, Turlure, Pascal, Reman, Oumedaly, Revel, Thierry de, Gastaud, Lauris, Gunzburg, Noémie de, Contentin, Nathalie, Henry, Estelle, Marolleau, Jean-Pierre, Aljijakh, Ahmad, Rousselot, Philippe, Fenaux, Pierre, and Preudhomme, Claude

Subjects
*LEUKEMIA treatment, *TOXICITY testing, *HEMATOLOGY, *DRUG dosage, *DRUG efficacy
Abstract

The article presents a study which investigates the effect of gemtuzumab ozogamicin to the improvement of patients with leukemia without causing excessive toxicity. The study uses the randomized open-label phase three analysis in patients aged 50-70 years in haematology centres in France. Results show that the safe delivery of higher cumulative doses is allowed by the use of fractionated lower doses of gemtuzumab ozogamicin.

Published
2012
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