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1. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.

Author

Beaugerie, Laurent, Brousse, Nicole, Bouvier, Anne Marie, Colombel, Jean Frédéric, Lémann, Marc, Cosnes, Jacques, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Gendre, Jean Pierre, Simon, Tabassome, Maynadié, Marc, Hermine, Olivier, Faivre, Jean, and Carrat, Fabrice

Subjects
*LYMPHOPROLIFERATIVE disorders, *INFLAMMATORY bowel diseases, *CHRONIC diseases, *INFLAMMATION, *CROHN'S disease, *GASTROENTERITIS
Abstract

The article presents a study which assessed the risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease. During a three-year follow-up, cases of lymphoproliferative disorder were compared with the number of cases expected in the general population with the same age and sex distributions. The risk of lymphoproliferative disorder was found to be higher in patients exposed to thiopurines. According to the article, the excess risk of lymphoproliferative disorder in patients taking thiopurines for chronic inflammatory might be caused by inflammatory itself, by thiopurine exposure, or a combination of two.

Published
2009
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