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Your search keyword '"Senior, Kathryn"' showing total 2 results
Start Over Author "Senior, Kathryn" Region africa Publisher lancet
2 results on '"Senior, Kathryn"'

1. Natural selection may reduce susceptibility to AIDS.

Author

Senior, Kathryn

Subjects
*HIV, *NATURAL selection, *CHEMOKINES, *AIDS, *NATURAL immunity, *GENETICS
Abstract

Discusses a study which shows that the high prevalence of HIV in Africa creates conditions for natural selection of variants that affect the time between HIV infection and the onset of AIDS. Selection pressures exerted on CCR5, a cell-surface receptor for chemokines; Expectation that the HIV epidemic will also affect alleles associated with resistance to HIV infection; Other genetic factors that might increase resistance to AIDS.

Published
2001
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2. Basis of HIV resistance suggests new vaccine strategy.

Author

Senior, Kathryn and Senior, K

Subjects
*HIV, *IMMUNE response, *SEX workers, *VACCINES, *IMMUNOLOGY, *HIV prevention, *HIV infection epidemiology, *AIDS vaccines, *CELLULAR immunity, *COMPARATIVE studies, *HIV infections, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *REFERENCE values, *RESEARCH, *RISK assessment, *STATISTICAL sampling, *T cells, *EVALUATION research, *DISEASE incidence, *HIV seroconversion, *HIV seronegativity, *PHARMACODYNAMICS
Abstract

Reports that a study of the immune responses in sex workers in Nairobi, Kenya, revealed that women who remain seronegative for HIV for several years mounted cytotoxic T lymphocyte responses to a different set of epitopes than those who were HIV positive. Trial of a vaccine that includes the seronegative-specific isotopes; Difficulty of developing a vaccine in Africa, because of genetic variability of the virus and the host population; Outlook for another vaccine that is being tested.

Published
2001
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