1. Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele
- Author
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Helena Katherina Van Schalkwyk, Natália Bordin Andriguetti, Andrew A. Somogyi, Joseph Tucci, Daniel T. Barratt, and Paul Pumuye
- Subjects
Adult ,Cyclopropanes ,Male ,medicine.medical_specialty ,Efavirenz ,CYP2B6 ,Adolescent ,Genotype ,HIV Infections ,RM1-950 ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Article ,chemistry.chemical_compound ,Papua New Guinea ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,Gene Frequency ,Internal medicine ,parasitic diseases ,medicine ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Allele ,Adverse effect ,Allele frequency ,Cytochrome P-450 CYP2B6 Inducers ,Aged ,Uncategorized ,business.industry ,General Neuroscience ,Research ,General Medicine ,Articles ,Middle Aged ,medicine.disease ,Benzoxazines ,Cytochrome P-450 CYP2B6 ,chemistry ,Alkynes ,Female ,Therapeutics. Pharmacology ,Public aspects of medicine ,RA1-1270 ,business ,AIDS Population - Abstract
Papua New Guinea (PNG) has a high HIV/AIDS prevalence and very high frequency of the CYP2B6 c.516G>T (rs3745274) variant. We have conducted the first investigation of the impact of c.516G>T and patient demographics on plasma efavirenz (EFV) and 8‐hydroxyefavirenz (8OH‐EFV) concentrations, metabolic ratio (8OH‐EFV/EFV) (MR), and their association with adverse effects, in PNG patients with HIV/AIDS. For 156 PNG patients with HIV/AIDS taking EFV 600 mg/day (for 3–156 months), plasma EFV and 8OH‐EFV concentrations were quantified, CYP2B6 c.516G>T genotyped, and demographic and self‐reported adverse effects data recorded. Genotype differences in EFV and 8OH‐EFV concentrations, MR, and percent within therapeutic range (1000–4000 ng/ml) were examined, in addition to EFV and 8OH‐EFV concentration differences between patients experiencing adverse effects. CYP2B6 c.516T allele frequency was 53%. Plasma EFV (p
- Published
- 2022
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