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Objective To research the analgesic effect of galanin on native rats, inflammatory rats and neuropathic rats in nucleus accumbens (NAc), and to explore its mechanism. Methods　A inflammatory pain model was prepared by subcutaneous injection of carrageine into rat’s plantar, while the model of neuralgia was prepared by ligation of the left sciatic nerve. The hind-paw withdraw latency (HWL)induced by thermal stimulation and the hind-paw withdraw threshold (HWT)induced by mechanical stimulation were measured to reflect the pain threshold. The expression of galanin receptors (GalRs) in the nucleus accumbens of inflammatory and neuropathic rats were detected by western blot ( WB). Results 1. The HWL of normal ( Pleft < 0.05; Pright < 0.01), inflammatory (Pleft < 0.001; Pright < 0.001)and neuropathic (Pleft < 0.001; Pright < 0.001) rats were increased by injection of galanin into nucleus accumbens, and the HWT of normal (Pleft < 0.001; Pright < 0.01), inflammatory (Pleft < 0.001; Pright < 0.001)and neuropathic (Pleft < 0.001; Pright < 0.001) rats also were increased. 2. The antinociception of galanin on the rats with inflammatory (HWL: Pleft < 0.05, Pright < 0.05; HWT: Pleft < 0.01, Pright < 0.05)or neuropathic pain (HWL: Pleft < 0.05, Pright < 0.05; HWT: Pleft < 0.001, Pright < 0.001)was stronger than that of the native rats. However, the antinociception of galanin on the rats with the inflammatory pain and neuropathic pain was not significantly different (P > 0.05). 3. The expressions of GalR1 were increased in rats after 3 hours of subcutaneous injection of carrageine (P < 0.001) and 14 days of sciatic nerve ligation (P < 0.001), and the expressions of GalR2 also were increased in rats after 3 hours of subcutaneous injection of carrageine (P < 0.05) and 14 days of sciatic nerve ligation ( P < 0.05). Conclusion Intra-NAc injection of galanin has the antinociceptive effects on native, inflammatory and neuralgia rats and the antinociceptive effect of galanin in rats is induced by the activation of GalRs. [ABSTRACT FROM AUTHOR]