21 results on '"Kyung Ae Lee"'
Search Results
2. 2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
- Author
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Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Nan Hee Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, YoonJu Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae Jin Kim, Hyun Min Kim, Jung Hae Ko, Nam Hoon Kim, Chong Hwa Kim, Jeeyun Ahn, Tae Jung Oh, Soo-Kyung Kim, Jaehyun Kim, Eugene Han, Sang-Man Jin, Won Suk Choi, and Min Kyong Moon
- Subjects
diabetes mellitus ,practice guideline ,prediabetic state ,republic of korea ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
In May 2023, the Committee of Clinical Practice Guidelines of the Korean Diabetes Association published the revised clinical practice guidelines for Korean adults with diabetes and prediabetes. We incorporated the latest clinical research findings through a comprehensive systematic literature review and applied them in a manner suitable for the Korean population. These guidelines are designed for all healthcare providers nationwide, including physicians, diabetes experts, and certified diabetes educators who manage patients with diabetes or individuals at risk of developing diabetes. Based on recent changes in international guidelines and the results of a Korean epidemiological study, the recommended age for diabetes screening has been lowered. In collaboration with the relevant Korean medical societies, recently revised guidelines for managing hypertension and dyslipidemia in patients with diabetes have been incorporated into this guideline. An abridgment containing practical information on patient education and systematic management in the clinic was published separately.
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- 2023
- Full Text
- View/download PDF
3. Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
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Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon, and on Behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association
- Subjects
age ,diabetes mellitus, type 2 ,diagnosis ,prediabetic state ,risk factors ,screening ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Diabetes screening serves to identify individuals at high-risk for diabetes who have not yet developed symptoms and to diagnose diabetes at an early stage. Globally, the prevalence of diabetes is rapidly increasing. Furthermore, obesity and/or abdominal obesity, which are major risk factors for type 2 diabetes mellitus (T2DM), are progressively increasing, particularly among young adults. Many patients with T2DM are asymptomatic and can accompany various complications at the time of diagnosis, as well as chronic complications develop as the duration of diabetes increases. Thus, proper screening and early diagnosis are essential for diabetes care. Based on reports on the changing epidemiology of diabetes and obesity in Korea, as well as growing evidence from new national cohort studies on diabetes screening, the Korean Diabetes Association has updated its clinical practice recommendations regarding T2DM screening. Diabetes screening is now recommended in adults aged ≥35 years regardless of the presence of risk factors, and in all adults (aged ≥19) with any of the risk factors. Abdominal obesity based on waist circumference (men ≥90 cm, women ≥85 cm) was added to the list of risk factors.
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- 2022
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- View/download PDF
4. Influence of Glucose Fluctuation on Peripheral Nerve Damage in Streptozotocin-Induced Diabetic Rats
- Author
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Yu Ji Kim, Na Young Lee, Kyung Ae Lee, Tae Sun Park, and Heung Yong Jin
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diabetes mellitus ,diabetic neuropathies ,insulin ,peripheral nerves ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background It is unclear whether glycemic variability (GV) is a risk factor for diabetic peripheral neuropathy (DPN), and whether control of GV is beneficial for DPN. The purpose of this study was to investigate the effect of GV on peripheral nerve damage by inducing glucose fluctuation in streptozotocin-induced diabetic rats. Methods Rats were divided into four groups: normal (normal glucose group [NOR]), diabetes without treatment (sustained severe hyperglycemia group; diabetes mellitus [DM]), diabetes+once daily insulin glargine (stable hyperglycemia group; DM+LAN), and diabetes+once daily insulin glargine with twice daily insulin glulisine (unstable glucose fluctuation group; DM+Lantus [LAN]+Apidra [API]). We measured anti-oxidant enzyme levels and behavioral responses against tactile, thermal, and pressure stimuli in the plasma of rats. We also performed a quantitative comparison of cutaneous and sciatic nerves according to glucose fluctuation. Results At week 24, intraepidermal nerve fiber density was less reduced in the insulin-administered groups compared to the DM group (P0.05; 16.2±1.6, 12.4±2.0, 14.3±0.9, and 13.9±0.6 for NOR, DM, DM+LAN, and DM+LAN+API, respectively). The DM group exhibited significantly decreased glutathione levels compared to the insulin-administered groups (2.64±0.10 μmol/mL, DM+LAN; 1.93±0.0 μmol/mL, DM+LAN+API vs. 1.25±0.04 μmol/mL, DM; P
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- 2022
- Full Text
- View/download PDF
5. Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
- Author
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Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Kim, Hye Soon Kim, Il Seong Nam-Goong, Eun Sook Kim, Jin Ook Chung, Dong-Hyeok Cho, Chang Won Lee, Young Il Kim, Dong Jin Chung, Kyu Chang Won, In Joo Kim, Tae Sun Park, Duk Kyu Kim, and Hosang Shon
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diabetes mellitus, type 2 ,drug therapy, combination ,hypoglycemic agents ,injections ,insulin ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM). Methods From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated. Results In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, −1.1%±1.2%; P
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- 2021
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- View/download PDF
6. Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats
- Author
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Kyung Ae Lee, Heung Yong Jin, Na Young Lee, Yu Ji Kim, and Tae Sun Park
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Diabetes mellitus, experimental ,Diabetic nephropathies ,Diabetic neuropathies ,Peripheral nerves ,Sodium-glucose transporter 2 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P
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- 2018
- Full Text
- View/download PDF
7. Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from Diabetic versus Normal Mice
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Kyung Ae Lee, Na Young Lee, Tae Sun Park, and Heung Yong Jin
- Subjects
Adipose tissue ,Diabetes mellitus ,Neuropathy ,Peripheral nerves ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control mice were used. Epididymal adipose tissue from diabetic db/db mice with that from control heterozygous db/m mice was compared using confocal microscopy-based method to visualize intact whole adipose tissue. Immunohistochemistry with tyrosine hydroxylase for sympathetic (SP), choline acetyltransferase for parasympathetic (PSP), and protein gene product 9.5 (PGP 9.5) for whole autonomic nerves was performed. The quantity of immunostained portion of SP, PSP, and PGP 9.5 stained nerve fibers showed decreased trend in diabetic group; however, the ratio of SP/PSP of adipose tissue was higher in diabetic group compared with control group as follows (0.70±0.30 vs. 0.95±0.25, P
- Published
- 2018
- Full Text
- View/download PDF
8. The Relationship between Anemia and the Initiation of Dialysis in Patients with Type 2 Diabetic Nephropathy
- Author
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Sun Hee Kim, Kyung Ae Lee, Heung Yong Jin, Hong Sun Baek, and Tae Sun Park
- Subjects
Anemia ,Diabetes ,Dialysis ,Nephropathy ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundAnemia is associated with various poor clinical outcomes in chronic kidney disease patients. The aim of this study was to investigate the relationship between anemia and the initiation degree and time of dialysis in type 2 diabetic nephropathy patients.MethodsThis observational retrospective study included 130 type 2 diabetic nephropathy patients in Korea. The existence of anemia, the degree and time of dialysis initiation were reviewed. Clinical characteristics and variables were also compared.ResultsThe levels of hemoglobin and serum creatinine were significantly correlated with the dialysis initiation (P
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- 2015
- Full Text
- View/download PDF
9. Relationship between the Korean Version Survey of the Autonomic Symptoms Score and Cardiac Autonomic Neuropathy Parameters in Patients with Diabetic Peripheral Neuropathy
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Sun Hee Kim, Kyung Ae Lee, Heung Yong Jin, Hong Sun Baek, and Tae Sun Park
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Autonomic neuropathy ,Diabetes ,Survey of autonomic symptom scale ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundThe Survey of Autonomic Symptom (SAS) scale was reported as an easy instrument to assess the autonomic symptoms in patients with early diabetic neuropathy. In this study, we investigated the relationship between the SAS scale and the parameters of cardiac autonomic neuropathy (CAN) in Korean patients with diabetic peripheral neuropathy (DPN).MethodsThe SAS scale was tested in 30 healthy controls and 73 patients with DPN at Chonbuk National University Hospital, in Korea. The SAS score was compared to the parameters of the CAN test and the total symptom score (TSS) for DPN in patients with DPN.ResultsThe SAS symptom score and total impact score were increased in patients with DPN compared to the control group (P=0.01), particularly in sudomotor dysfunction (P=0.01), and vasomotor dysfunction (P=0.01). The SAS score was increased in patients with CAN compared to patients without CAN (P
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- 2014
- Full Text
- View/download PDF
10. Effect of Granulocyte Colony-Stimulating Factor on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rat
- Author
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Kyung Ae Lee, Kyung Taek Park, Hea Min Yu, Heung Yong Jin, Hong Sun Baek, and Tae Sun Park
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Diabetes mellitus ,Granulocyte colony-stimulating factor ,Peripheral nerves ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
There are controversial reports about the effect of granulocyte colony-stimulating factor (G-CSF) in peripheral nerve protection. Therefore, the present study aimed to investigate the effect of G-CSF on peripheral nerves in streptozotocin (STZ) induced diabetic rats. After STZ or vehicle injection, rats were divided into five groups (n=6) as follows: normal+vehicle, normal+G-CSF (50 µg/kg for 5 days), diabetes mellitus (DM)+vehicle, DM+G-CSF (50 µg/kg for 5 days), and DM+G-CSF extension (50 µg/kg for 5 days and followed by two injections per week up to 24 weeks). Our results showed that the current perception threshold was not significantly different among experimental groups. G-CSF treatment inhibited the loss of cutaneous nerves and gastric mucosal small nerve fibers in morphometric comparison, but statistical significance was not observed. The present results demonstrated that G-CSF has no harmful but minimal beneficial effects with respect to peripheral nerve preservation in diabetic rats.
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- 2013
- Full Text
- View/download PDF
11. Influence of Glucose Fluctuation on Peripheral Nerve Damage in Streptozotocin-Induced Diabetic Rats
- Author
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Kyung Ae Lee, Na Young Lee, Heung Yong Jin, Yu Ji Kim, and Tae Sun Park
- Subjects
diabetic neuropathies ,Insulin glulisine ,insulin ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Nerve fiber ,Streptozocin ,Diseases of the endocrine glands. Clinical endocrinology ,Diabetes Mellitus, Experimental ,Rats, Sprague-Dawley ,Internal medicine ,Diabetes mellitus ,medicine ,Animals ,Glycemic ,business.industry ,Insulin glargine ,Insulin ,RC648-665 ,medicine.disease ,Streptozotocin ,Sciatic Nerve ,Rats ,peripheral nerves ,Glucose ,Endocrinology ,Peripheral neuropathy ,medicine.anatomical_structure ,diabetes mellitus ,business ,medicine.drug - Abstract
Background: It is unclear whether glycemic variability (GV) is a risk factor for diabetic peripheral neuropathy (DPN), and whether control of GV is beneficial for DPN. The purpose of this study was to investigate the effect of GV on peripheral nerve damage by inducing glucose fluctuation in streptozotocin-induced diabetic rats.Methods: Rats were divided into four groups: normal (normal glucose group [NOR]), diabetes without treatment (sustained severe hyperglycemia group; diabetes mellitus [DM]), diabetes+once daily insulin glargine (stable hyperglycemia group; DM+LAN), and diabetes+once daily insulin glargine with twice daily insulin glulisine (unstable glucose fluctuation group; DM+Lantus [LAN]+Apidra [API]). We measured anti-oxidant enzyme levels and behavioral responses against tactile, thermal, and pressure stimuli in the plasma of rats. We also performed a quantitative comparison of cutaneous and sciatic nerves according to glucose fluctuation.Results: At week 24, intraepidermal nerve fiber density was less reduced in the insulin-administered groups compared to the DM group (P0.05; 16.2±1.6, 12.4±2.0, 14.3±0.9, and 13.9±0.6 for NOR, DM, DM+LAN, and DM+LAN+API, respectively). The DM group exhibited significantly decreased glutathione levels compared to the insulin-administered groups (2.64±0.10 μmol/mL, DM+LAN; 1.93±0.0 μmol/mL, DM+LAN+API vs. 1.25±0.04 μmol/mL, DM; P
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- 2022
12. Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
- Author
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Dong Jin Chung, Young Sang Lyu, Tae Sun Park, In Joo Kim, Jun Sung Moon, Young Il Kim, Heung Yong Jin, Eonju Jeon, Ju Hyung Lee, Eun Sook Kim, Seung Min Chung, Sang Soo Kim, Sung Woo Kim, Jung Eun Jang, Tae Nyun Kim, Jin Ook Chung, Nan Hee Cho, Sunghwan Suh, Kyu Chang Won, Chang Won Lee, Duk Kyu Kim, Hye Soon Kim, Jeong Mi Kim, Hosang Shon, Min Hee Jang, Sang Yong Kim, Il Seong Nam-Goong, Dong Hyeok Cho, Kyung Ae Lee, Jin Hwa Kim, and Mi-Kyung Kim
- Subjects
Blood Glucose ,Drug ,medicine.medical_specialty ,Combination therapy ,Drug/Regimen ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,medicine.medical_treatment ,Drug therapy, combination ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Diseases of the endocrine glands. Clinical endocrinology ,Injections ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,medicine ,Insulin ,Humans ,Hypoglycemic Agents ,Retrospective Studies ,media_common ,Glycated Hemoglobin ,business.industry ,Type 2 Diabetes Mellitus ,Retrospective cohort study ,RC648-665 ,medicine.disease ,Regimen ,Diabetes Mellitus, Type 2 ,Oral hypoglycemic agents ,Original Article ,business - Abstract
Background Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM). Methods From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated. Results In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, −1.1%±1.2%; P
- Published
- 2021
13. Management of Type 2 Diabetes Mellitus in Adolescents and Young Adults
- Author
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Kyung Ae Lee
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Diabetes mellitus ,Medicine ,Type 2 Diabetes Mellitus ,Young adult ,business ,medicine.disease - Published
- 2020
14. Relationship between the Korean Version Survey of the Autonomic Symptoms Score and Cardiac Autonomic Neuropathy Parameters in Patients with Diabetic Peripheral Neuropathy
- Author
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Heung Yong Jin, Tae Sun Park, Sun Hee Kim, Kyung Ae Lee, and Hong Sun Baek
- Subjects
medicine.medical_specialty ,Survey of autonomic symptom scale ,Complications ,Diabetic neuropathy ,lcsh:RC648-665 ,business.industry ,Endocrinology, Diabetes and Metabolism ,fungi ,Diabetes ,food and beverages ,Cardiac autonomic neuropathy ,medicine.disease ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Autonomic neuropathy ,Peripheral neuropathy ,Internal medicine ,Diabetes mellitus ,medicine ,Physical therapy ,Autonomic symptoms ,Original Article ,In patient ,business ,Korean version - Abstract
Background: The Survey of Autonomic Symptom (SAS) scale was reported as an easy instrument to assess the autonomic symp toms in patients with early diabetic neuropathy. In this study, we investigated the relationship between the SAS scale and the parameters of cardiac autonomic neuropathy (CAN) in Korean patients with diabetic peripheral neuropathy (DPN). Methods: The SAS scale was tested in 30 healthy controls and 73 patients with DPN at Chonbuk National University Hospital, in Korea. The SAS score was compared to the parameters of the CAN test and the total symptom score (TSS) for DPN in patients with DPN. Results: The SAS symptom score and total impact score were increased in patients with DPN compared to the control group (P=0.01), particularly in sudomotor dysfunction (P=0.01), and vasomotor dysfunction (P=0.01). The SAS score was increased in patients with CAN compared to patients without CAN (P
- Published
- 2014
15. Effect of Granulocyte Colony-Stimulating Factor on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rat
- Author
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Tae Sun Park, Hong Sun Baek, Kyung Ae Lee, Kyung Taek Park, Hea Min Yu, and Heung Yong Jin
- Subjects
medicine.medical_specialty ,Pathology ,Complications ,Diabetic rat ,Endocrinology, Diabetes and Metabolism ,Granulocyte ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Granulocyte colony-stimulating factor ,Diabetes mellitus ,Peripheral nerve ,Statistical significance ,Internal medicine ,medicine ,Peripheral nerves ,lcsh:RC648-665 ,business.industry ,Brief Report ,medicine.disease ,Streptozotocin ,Peripheral ,medicine.anatomical_structure ,Endocrinology ,business ,medicine.drug - Abstract
There are controversial reports about the effect of granulocyte colony-stimulating factor (G-CSF) in peripheral nerve protection. Therefore, the present study aimed to investigate the effect of G-CSF on peripheral nerves in streptozotocin (STZ) induced diabetic rats. After STZ or vehicle injection, rats were divided into five groups (n=6) as follows: normal+vehicle, normal+G-CSF (50 µg/kg for 5 days), diabetes mellitus (DM)+vehicle, DM+G-CSF (50 µg/kg for 5 days), and DM+G-CSF extension (50 µg/kg for 5 days and followed by two injections per week up to 24 weeks). Our results showed that the current perception threshold was not significantly different among experimental groups. G-CSF treatment inhibited the loss of cutaneous nerves and gastric mucosal small nerve fibers in morphometric comparison, but statistical significance was not observed. The present results demonstrated that G-CSF has no harmful but minimal beneficial effects with respect to peripheral nerve preservation in diabetic rats.
- Published
- 2013
16. The Correlation and Accuracy of Glucose Levels between Interstitial Fluid and Venous Plasma by Continuous Glucose Monitoring System
- Author
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Woong Ji Kim, Heung Yong Jin, Seon Mee Kang, Hong Sun Baek, Kyung Ae Lee, Min-Gul Kim, Ji Hyun Park, Young Ha Baek, Tae Sun Park, and Soo Wan Chae
- Subjects
medicine.medical_specialty ,Pathology ,Continuous glucose monitoring ,business.industry ,Venous Plasma ,medicine.disease ,Extracellular fluid ,Plasma ,Interstitial fluid ,Internal medicine ,Diabetes mellitus ,Continuous glucose monitoring system ,Cardiology ,Medicine ,Original Article ,business ,human activities - Abstract
Background Clinical experience with the continuous glucose monitoring systems (CGMS) is limited in Korea. The objective of this study is to evaluate the accuracy of the CGMS and the correlation between interstitial fluid and venous plasma glucose level in Korean healthy male subjects. Methods Thirty-two subjects were served with glucose solution contained same amount of test food's carbohydrate and test foods after separate overnight fasts. CGMS was performed over 3 days during hopitalization for each subjects. Venous plasma glucose measurements were carried out during 4 hours (0, 0.25, 0.5, 0.75, 1, 2, 4 hours) just before and after glucose solution and test food load. The performance of the CGMS was evaluated by comparing its readings to those obtained at the same time by the hexokinase method using the auto biochemistry machine (Hitachi 7600-110). Also, correlations between glucose recorded with CGMS and venous plasma glucose value were examined. Results CGMS slightly underestimated the glucose value as compared with the venous plasma glucose level (16.3 ± 22.2 mg/dL). Correlation between CGMS and venous plasma glucose values throughout sensor lifetime is 0.73 (regression analysis: slope = 1.08, intercept = 8.38 mg/dL). Sensor sensitivity can deteriorate over time, with correlations between venous blood glucose and CGMS values dropping from 0.77 during 1st day to 0.65 during 2nd and 3rd day. Conclusion The accuracy of data provided by CGMS may be less than expected. CGMS sensor sensitivity is decreased with the passage of time. But, from this study, CGMS can be used for glucose variability tendency monitoring conveniently to the Korean.
- Published
- 2010
17. Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from db/db Diabetic versus Normal Mice
- Author
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Kyung Ae Lee, Heung Yong Jin, Na Young Lee, and Tae Sun Park
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Adipose tissue ,030209 endocrinology & metabolism ,White adipose tissue ,030204 cardiovascular system & hematology ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,chemistry.chemical_compound ,Diabetes mellitus ,0302 clinical medicine ,Internal medicine ,Adipocyte ,medicine ,Peripheral nerves ,lcsh:RC648-665 ,Tyrosine hydroxylase ,business.industry ,Brief Report ,medicine.disease ,Choline acetyltransferase ,eye diseases ,Neuropathy ,Peripheral ,Endocrinology ,chemistry ,Immunohistochemistry ,business ,Complication - Abstract
Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control mice were used. Epididymal adipose tissue from diabetic db/db mice with that from control heterozygous db/m mice was compared using confocal microscopy-based method to visualize intact whole adipose tissue. Immunohistochemistry with tyrosine hydroxylase for sympathetic (SP), choline acetyltransferase for parasympathetic (PSP), and protein gene product 9.5 (PGP 9.5) for whole autonomic nerves was performed. The quantity of immunostained portion of SP, PSP, and PGP 9.5 stained nerve fibers showed decreased trend in diabetic group; however, the ratio of SP/PSP of adipose tissue was higher in diabetic group compared with control group as follows (0.70±0.30 vs. 0.95±0.25, P
- Published
- 2018
18. Glycemic Control in Cancer Patients
- Author
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Kyung Ae Lee, Hong Sun Baek, and Tae Sun Park
- Subjects
medicine.medical_specialty ,business.industry ,Cancer ,030209 endocrinology & metabolism ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,medicine ,Terminal care ,030212 general & internal medicine ,Intensive care medicine ,business ,Glycemic - Published
- 2016
19. The Relationship between Anemia and the Initiation of Dialysis in Patients with Type 2 Diabetic Nephropathy
- Author
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Kyung Ae Lee, Hong Sun Baek, Tae Sun Park, Sun Hee Kim, and Heung Yong Jin
- Subjects
medicine.medical_specialty ,Complications ,Anemia ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Renal function ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Gastroenterology ,Nephropathy ,Diabetic nephropathy ,chemistry.chemical_compound ,hemic and lymphatic diseases ,Diabetes mellitus ,Internal medicine ,medicine ,Dialysis ,Creatinine ,lcsh:RC648-665 ,business.industry ,Diabetes ,medicine.disease ,Surgery ,chemistry ,Original Article ,business ,Kidney disease - Abstract
Background: Anemia is associated with various poor clinical outcomes in chronic kidney disease patients. The aim of this study was to investigate the relationship between anemia and the initiation degree and time of dialysis in type 2 diabetic nephropathy patients. Methods: This observational retrospective study included 130 type 2 diabetic nephropathy patients in Korea. The existence of anemia, the degree and time of dialysis initiation were reviewed. Clinical characteristics and variables were also compared. Results: The levels of hemoglobin and serum creatinine were significantly correlated with the dialysis initiation ( P
- Published
- 2015
20. The Education Effect of Glucometer Use on the Glucose Levels and the Glucose Value Comparison among Diverse Glucometers
- Author
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Kyung Ae Lee, Woong Ji Kim, Ji Hyun Park, Heung Yong Jin, Hong Sun Baek, So-Yeon Jeon, and Tae Sun Park
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Diabetes mellitus ,medicine ,medicine.disease ,business ,Value (mathematics) - Published
- 2011
21. Psychosocial Therapy of Obesity: Based on the Transtheoretical Model
- Author
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Kyung Ae Lee
- Subjects
business.industry ,Psychosocial therapy ,Transtheoretical model ,Medicine ,business ,medicine.disease ,Obesity ,Clinical psychology - Published
- 2008
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