1. Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
- Author
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Seul Gi Yoo, Kyoung Hwa Lee, Kyungdo Han, Yeonju La, Da Eun Kwon, and Sang Hoon Han
- Subjects
Adult ,Male ,medicine.medical_specialty ,endocrine system diseases ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Population ,Cytomegalovirus ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Republic of Korea ,medicine ,Humans ,Disease ,education ,Aged ,Dyslipidemias ,education.field_of_study ,Type 1 diabetes ,business.industry ,Incidence ,Incidence (epidemiology) ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Diabetes mellitus, type 2 ,Odds ratio ,Middle Aged ,medicine.disease ,Case-Control Studies ,Cytomegalovirus Infections ,Hypertension ,Cohort ,Kidney Failure, Chronic ,Original Article ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Background: A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated im mune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evalu ated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). Methods: From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 mil lion, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Diseases and Related-Health Problems 10th Revision (ICD-10) B25 code between 2010 and 2014 after exclusion of patients with T2DM to 2006. The 2,880 control patients without T2DM from 2006 to cohort entry point were selected between 2010 and 2014 by age, sex matching with case group. The subjects without new-onset T2DM were followed until 2015. T2DM, hypertension (HTN), dyslip idemia (DYS), and end-stage renal disease (ESRD) were coded as ICD-10. Results: The frequency of new-onset T2DM in case group was significantly higher than that in control (5.6% vs. 2.2%, P
- Published
- 2019