1. Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
- Author
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Cheng-Chen Chang, Yi-Cheng Liao, Yu-An Chen, and Yen-Jen Chen
- Subjects
Liver injury ,medicine.medical_specialty ,business.industry ,Case Report ,medicine.disease ,Clinical trial ,Behavioral Neuroscience ,Psychiatry and Mental health ,Increased risk ,Internal medicine ,medicine ,Agomelatine ,Major depression ,Pharmacology (medical) ,Liver function ,Acute hepatitis ,Risk factor ,business ,Depression (differential diagnoses) ,medicine.drug - Abstract
Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.
- Published
- 2021