1. The Impact of Vascular Access for In-Hospital Major Bleeding in Patients with Acute Coronary Syndrome at Moderate- to Very High-Bleeding Risk
- Author
-
Myung Ho Jeong, Byung Ryul Cho, Youngkeun Ahn, Hyoung-Mo Yang, Hyunmin Choe, Hee Yeol Kim, Won-Yong Shin, Min Soo Hyon, Byung Ok Kim, Keum Soo Park, Seung-Woon Rha, Kyoo Rok Han, Sang Sik Jung, Keun Ho Park, Moo Hyun Kim, Jang Whan Bae, Junghan Yoon, and Kwang Soo Cha
- Subjects
Male ,Acute coronary syndrome ,medicine.medical_specialty ,Blood transfusion ,Cardiovascular Disorders ,medicine.medical_treatment ,Hemorrhage ,Kaplan-Meier Estimate ,Percutaneous Coronary Intervention ,Risk Factors ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Hospital Mortality ,Myocardial infarction ,Acute Coronary Syndrome ,Aged ,Retrospective Studies ,business.industry ,Unstable angina ,Mortality rate ,Percutaneous coronary intervention ,Retrospective cohort study ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Surgery ,Femoral Artery ,Treatment Outcome ,Radial Artery ,Female ,Stents ,Original Article ,business - Abstract
The aim of our study was to determine the impact of vascular access on in-hospital major bleeding (IHMB) in acute coronary syndrome (ACS). We analyzed 995 patients with non-ST elevation myocardial infarction and unstable angina at the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) moderate- to very high-bleeding risk scores in trans-radial intervention (TRI) retrospective registry from 16 centers in Korea. A total of 402 patients received TRI and 593 patients did trans-femoral intervention (TFI). The primary end-point was IHMB as defined in the CRUSADE. There were no significant differences in in-hospital and 1-yr mortality rates between two groups. However, TRI had lower incidences of IHMB and blood transfusion than TFI (6.0% vs 9.4%, P = 0.048; 4.5% vs 9.4%, P = 0.003). The patients suffered from IHMB had higher incidences of in-hospital and 1-yr mortality than those free from IHMB (3.1% vs 15.0%, P < 0.001; 7.2% vs 30.0%, P < 0.001). TRI was an independent negative predictor of IHMB (odds ratio, 0.305; 95% confidence interval, 0.109-0.851; P = 0.003). In conclusions, IHMB is still significantly correlated with in-hospital and 1-yr mortality. Our study suggests that compared to TFI, TRI could reduce IHMB in patients with ACS at moderate- to very high-bleeding risk.
- Published
- 2013