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1. Plasma Levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA125a-5p as Potential Diagnostic Biomarkers for Rheumatoid Arthritis

Author

Fatemeh Safari, Shafieh Movassaghi, Majid Kabuli, Mojtaba Saffari, Abdolrahman Rostamian, Zeinab Imani-Saber, Mohsen Ghadami, and Elia Damavandi

Subjects
Adult, Male, medicine.medical_specialty, Inflammation, Disease, Real-Time Polymerase Chain Reaction, Gastroenterology, Arthritis, Rheumatoid, Predictive Value of Tests, Internal medicine, microRNA, Murine leukemia virus, Humans, Immunology and Allergy, Diagnostic biomarker, Medicine, Circulating MicroRNA, Rheumatoid arthritis, Autoimmune disease, biology, Reverse Transcriptase Polymerase Chain Reaction, business.industry, RNA, Middle Aged, Prognosis, medicine.disease, biology.organism_classification, MiR-24-3p, Up-Regulation, MicroRNAs, Case-Control Studies, MiR-146a, Female, medicine.symptom, business, Biomarkers
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by inflammation of the articular tissue. This study aims to evaluate the expression of microRNA (miR)-146a-5p, miR-24-3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. This study was performed on 50 RA patients and 50 healthy controls. Five microliters of blood were taken from each patient/control. Plasma RNA was extracted using the Trisol solution. cDNAs were synthesized; using moloney murine leukemia virus (MMLV) and deoxynucleoside triphosphate (dNTP). Real-time PCR was performed using SYBR green kit. The mean expression of miR-146a-5p, miR-24-3p, and miR-125a-5p in the RA group were 8.1±1.9, 6.5±1.2, and 6.8±2.2 and in the healthy group were 4.8±1.6, 3.6±2.2, and 3.4±1.7, respectively. Significant differences were also observed in the mean expression of these three miRNAs in four subgroups of RA patients with different disease activity based on disease activity score 28 (DAS28) (p

Published
2021

2. Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality

Author

Soghrat Faghihzadeh, Sussan K. Ardestani, Mohammad Mehdi Naghizadeh, Mostafa Mohammadi, Ali Mohammad Mohseni Majd, Bentolhoda Mohammad Shirazi, Tooba Ghazanfari, Hamid Emadi Kouchak, Nasim Khajavirad, Ensie Sadat Mirsharif, Alireza Abdollahi, Maedeh Mahmoodi Aliabadi, Saeed Mohammadi, Davoud Jamali, Sara Ghaffarpour, Jalil Arabkheradmand, Maryam Edalatifard, Mohammad Saber Zamani, Zahra Nasiri, Hossein Ghanaati, Maryam Rajabnia Chenary, Maryam Mahloujirad, Mohammad Salehi, Abdolrahman Rostamian, Mohammad Vodjgani, Alireza Izadi, Saeed Namaki, Seyed Ali Dehghan Manshadi, and Mohammad Taghi Beigmohammadi

Subjects
Male, medicine.medical_specialty, Neutrophils, Immunology, Blood sugar, Hematocrit, Severity of Illness Index, Gastroenterology, Procalcitonin, Transaminase, Cohort Studies, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Severity of illness, medicine, Humans, Immunology and Allergy, Lymphocyte Count, Inflammation, Creatinine, medicine.diagnostic_test, SARS-CoV-2, business.industry, Mortality rate, COVID-19, Complete blood count, Middle Aged, Survival Analysis, C-Reactive Protein, chemistry, Disease Progression, Medicine, Female, business, Biomarkers, 030215 immunology
Abstract

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) spread rapidly all over the world in late 2019 and caused critical illness and death in some infected patients. This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical patients (85.7%). Increased serum levels of blood sugar, urea, creatinine, uric acid, phosphorus, total bilirubin, serum glutamic-oxaloacetic transaminase, serum glutamic-oxaloacetic transaminase, lactic dehydrogenase, C-reactive protein, ferritin, and procalcitonin were significantly prevalent (p=0.002, p

Published
2021

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