1. Synthesis, Characterization and Cytotoxic Effect of Some New Thiazolyl Hydrazone Derivatives of 1-Indanone.
- Author
-
Nazim, Urooj, Narayanan, Silpa, Ali, Mohsin, Khan, Khalid Mohammed, Ali, Basharat, Li, Jonathan, Chen, Zhe-Sheng, Ahmed, Mansoor, and Yang, Dong-Hua
- Subjects
HYDRAZONE derivatives ,COLON cancer ,MASS spectrometry ,LUNG cancer ,PROSTATE cancer ,CHEMICAL synthesis - Abstract
Summary: In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25±0.02 to 5.04±0.2 µM. On the other hand all the compounds didn't show cytotoxic activity against other forms of human cancer cells. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF