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Objective: To assess correlation of Aspartate Aminotransferase (AST) to platelet ratio index with other biochemical markers such as white cell count, platelet count, hemoglobin, hematocrit and liver function tests in patients of dengue fever for disease severity. Methods: Data was collected from 223 dengue fever patients admitted to a hospital setting in an outbreak of 2022. Binary logistic regressions analysis was employed. AST to Platelet Ratio Index (APRI) was calculated and all parameters were studied to assess their association with the disease severity. Severity of dengue was based on development of complications like bleeding, shock, end organ damage and duration of stay in the hospital. Results: The analysis done by software SPSS version 26.0 showed that 3.6% of the patients were severely ill while 96.4% were non severe with mean duration of stay in the hospital of 4.95 days. Univariate analysis showed ALT and age have positive correlation with disease severity with CI 95% and APRI significant positive correlation was at CI 90%. Multivariate analysis showed age and APRI to have association with disease severity with OR 1.06 and OR 1.16 respectively (p <0.05). Area under the Receiver Operating Characteristic (ROC) curve for APRI was 0.59. Conclusion: In addition to other biochemical parameters APRI can be used as an independent marker of predicting severity of disease in dengue patients thus it can add value in timely management of the dengue patients. [ABSTRACT FROM AUTHOR]