1. The complete genome of equid herpesvirus-1 (EHV-1) field isolates from Argentina reveals an interspecific recombinant strain.
- Author
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Tau RL, Marandino AE, Panzera Y, Alamos F, Vissani MA, Romera SA, Pérez R, and Maidana SS
- Subjects
- Argentina, Animals, Horses virology, Recombination, Genetic, Horse Diseases virology, Open Reading Frames genetics, Whole Genome Sequencing, DNA, Viral genetics, Herpesvirus 1, Equid genetics, Herpesvirus 1, Equid isolation & purification, Herpesvirus 1, Equid classification, Genome, Viral genetics, Herpesviridae Infections veterinary, Herpesviridae Infections virology, Phylogeny
- Abstract
The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Argentina, E/745/99 and E/1297/07. The E745/99 genome shares 98.2% sequence identity with Ab4, a reference EHV-1 strain. The E/1297/07 genome shares 99.8% identity with NY03, a recombinant strain containing part of ORF64 and part of the intergenic region from Equid alphaherpesvirus-4 (EHV-4). The E/1297/07 genome has the same breakpoints as other United States and Japanese recombinants, including NY03. The recombinant regions have varying numbers of tandem repeat sequences and different minor parental sequences (EHV-4), suggesting distinct origins of the recombinant events. These are the first complete genomes of EHV-1 from Argentina and South America available in the Databases., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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