1. Regulatory effects of cytokine production in atopic allergic reaction by gammi-danguieumja.
- Author
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Na HJ, Shin HY, Kim NH, Kwon MW, Park EJ, Hong SH, Kim NI, and Kim HM
- Subjects
- Animals, Anti-Allergic Agents toxicity, Calcimycin, Cell Line, Cell Survival, Drugs, Chinese Herbal toxicity, Histamine Release drug effects, Humans, Interferon-gamma immunology, Interleukin-8 immunology, Ionophores, Mast Cells immunology, Rats, Rats, Sprague-Dawley, T-Lymphocytes immunology, Tetradecanoylphorbol Acetate analogs & derivatives, Tumor Necrosis Factor-alpha immunology, p-Methoxy-N-methylphenethylamine, Anti-Allergic Agents pharmacology, Cytokines immunology, Drugs, Chinese Herbal pharmacology, Mast Cells drug effects, T-Lymphocytes drug effects
- Abstract
Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. In addition, GD inhibited histamine release from activated mast cells. These results suggest that GD contributes to the regulation of atopic allergic reactions.
- Published
- 2004
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