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2 results on '"Toru, Kiguchi"'

1. Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

Author

Sayaka Kiso, Hiroyuki Sugiura, Taiga Kuroi, Rika Omote, Tomohiro Toji, Tatsunori Ishikawa, Sachiyo Okamoto, Naho Nomura, Taro Masunari, Nobuo Sezaki, Toru Kiguchi, and Mitsune Tanimoto

Subjects
chronic lymphocytic leukemia, acute myeloid leukemia, autopsy, flow cytometry, immunohistochemical staining, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.

Published
2021
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2. Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

Author

Tomohiro Toji, Taro Masunari, Rika Omote, Sayaka Kiso, Toru Kiguchi, Tatsunori Ishikawa, Taiga Kuroi, Mitsune Tanimoto, Sachiyo Okamoto, Hiroyuki Sugiura, Nobuo Sezaki, and Naho Nomura

Subjects
Pathology, medicine.medical_specialty, business.industry, Chronic lymphocytic leukemia, flow cytometry, Myeloid leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Case Report, Autopsy, acute myeloid leukemia, medicine.disease, autopsy, Oncology, immune system diseases, immunohistochemical staining, hemic and lymphatic diseases, Medicine, Atypical phenotype, chronic lymphocytic leukemia, business, neoplasms, RC254-282
Abstract

The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.

Published
2021

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