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Background: Cardiovascular diseases (CVDs) are the major cause of mortality and disability in patients with type 2 diabetes mellitus (T2DM). The increased risk of major cardiovascular (CV) events in patients with T2DM causes an estimated 12-year reduction in life expectancy. Despite their heightened CV risks, most T2DM patients do not meet treatment targets for multiple CV risk factors. Moreover, in the UAE, the incidence of cardiometabolic diseases is exceedingly high, impacting young patients and leading to a high burden of premature CV events. Summary: We propose this comprehensive cardiometabolic evaluation to address both glycemic control and early diagnosis of CV complications as well as early implementation of multifactorial intensive therapies that are evidence and guideline based. Widespread utilization and implementation of the guidelines in primary diabetic care, coupled with early referral to a CV or the relevant specialists, will result in a significant reduction of CV events and CV hospitalization in the UAE population. Hence, the Emirates Diabetes and Endocrine Society with the Emirates Cardiac Society collaborated for the first time to develop these recommendations. These will aid in the early identification of CV risk factors in persons with prediabetes and diabetes, as well as their effective assessment and management. These guidelines are aimed not just at primary care physicians but also specialists, perhaps leading to a more collaborative and multidisciplinary approach to the prevention, diagnosis, and treatment of patients with diabetes and CVD. Key Message: The establishment of combined cardiometabolic clinics providing comprehensive assessment and management in every major cardiology and diabetology center, particularly in patients who have already had a CV event, where the combined involvement of a cardiologist and a diabetologist in an intensive multifactorial outpatient program is urgently required to prevent recurrent CV events. In addition, establishing a National Cardiometabolic Registry is an essential element of this recommendation.

Introduction: The safety and effectiveness of gliclazide modified release (MR) in patients with type 2 diabetes mellitus (T2DM) who fasted during Ramadan were previously published. Here, we carried out a regional analysis among patients living in Gulf Cooperation Council (GCC) countries. Patients and Methods: DIA-RAMADAN was a real-world, observational, international, noncomparative study conducted in nine countries that included >1200 T2DM adults receiving gliclazide MR for at least 90 days before inclusion. The study comprised 2 visits: at inclusion, 6–8 weeks before the start of Ramadan (V0) and 4–6 weeks after the end of Ramadan (V1). The primary endpoint was the proportion of patients reporting ≥1 symptomatic hypoglycemic event as collected using a patient diary. Changes in HbA1c, fasting plasma glucose (FPG), and weight were also analyzed. This manuscript represents data collected in GCC countries (Kuwait, Saudi Arabia, and United Arab Emirates). Results: Data from 161 patients were analyzed: mean (SD) age 56.8 (10.6) years, 30.4% women, body mass index 29.1 (3.7) kg/m2, T2DM disease duration 6.7 (3.3) years, baseline HbA1c 7.9% (0.8). The proportions of patients reporting ≥1 symptomatic hypoglycemic event or confirmed hypoglycemia during Ramadan were 4.3% and 0.6%, respectively. No cases of severe hypoglycemia were reported. Significant reductions in main variables were observed before the start of Ramadan (V0) and 4–6 weeks after the end of Ramadan (V1): HbA1c (from 7.9 [0.8] to 7.6 [0.7]%; p value

Objective: The aim of this study is to assess the correlation between the findings in preoperative localization studies and biochemical parameters with the surgical outcome in patients with primary hyperparathyroidism. Design and Methods: In patients with hyperparathyroidism, preoperative localization imaging studies are considered important for their role in surgical cure, operative length, and extent of surgical incision. Sometimes discordant imaging studies lead to further extensive diagnostic work-up to avoid operative risks and may result in delay to surgical referral. In this single-center retrospective study at a tertiary referral center in Dubai, we evaluated the concordance of presurgical imaging modalities in primary hyperparathyroidism with the surgical outcome after parathyroidectomy. Results: This study included n = 59 patients. 74.6% were female, and the mean age was 52.59 years (SD = 13.6). Preoperative parathyroid sestamibi scans were done on n = 50 patients with 68% having a positive result. A radiology department neck ultrasound was done on n = 42 patients, 52% of whom had a positive finding for a parathyroid adenoma, while n = 17 patients required an endocrinology department neck ultrasound scan with 71% having a positive finding. Complete concordance of findings with the postoperative pathology result was found in 78% of patients who had a preoperative parathyroid sestamibi, 78% of patients who had a preoperative radiology department neck ultrasound, and 86% of patients with a preoperative endocrinology department ultrasound. There was no correlation between the preoperative laboratory values of calcium and PTH with the scan findings based on our data. Conclusion: Our results showed a high degree of complete concordance between the usual imaging modalities and surgical findings.