1. Incidence, Clinical Characteristics, Long-Term Course, and Comparison of Progressive and Nonprogressive Cases of Aphthous-Type Crohn's Disease: A Single-Center Cohort Study.
- Author
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Tsurumi, Kozue, Matsui, Toshiyuki, Hirai, Fumihito, Takatsu, Noritaka, Yano, Yutaka, Hisabe, Takashi, Sato, Yuho, Beppu, Takahiro, Fujiwara, Shoko, Ishikawa, Satoshi, Matsushima, Yu, Okado, Yuki, Ono, Yoichiro, Yoshizawa, Naoyuki, Nagahama, Takashi, Takaki, Yasuhiro, Yao, Kenshi, and Iwashita, akinori
- Subjects
CROHN'S disease diagnosis ,DISEASE progression ,CANKER sores ,SMALL intestine ulcers ,DIAGNOSIS - Abstract
Background/Aims: In Japan, aphthous-type Crohn's disease (type A CD) is thought to represent an early phase of Crohn's disease (CD), and diagnosis of type A CD is possible in the diagnostic criteria for CD in Japan. However, the details of type A CD are not well understood. Methods: Subjects comprised 649 CD patients diagnosed between 1985 and 2011. The incidence of type A CD over time was clarified in two periods (1985-2004 and 2005-2011). The course of type A CD was also investigated, and cases that did and did not progress to typical CD were compared. Results: No significant difference was seen in the incidence of type A CD between the two periods (5.2 vs. 8.5%, p = 0.125). Type A CD patients followed at our hospital progressed to typical CD at a rate of 59.3%. In comparing progressive and nonprogressive cases, the frequency of large, densely distributed aphthous lesions in the small intestine was higher among progressive cases (p = 0.018). Conclusion: Type A CD is an early phase of CD, and CD diagnostic criteria including early cases are valid in Japan. Copyright © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2013
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