El Hiar, Raida, Hober, Didier, Jaidane, Hela, Sané, Famara, M'hadheb-Gharbi, Manel Ben, Caloone, Delphine, Gharbi, Jawhar, and Aouni, Mahjoub
Subjects
RNA virus infections, ECHO viruses, COXSACKIEVIRUS diseases, CENTRAL nervous system diseases, LABORATORY mice, PATHOGENIC microorganisms, MENINGOENCEPHALITIS, NEUROTROPHINS
Abstract
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Buscarini, Maurizio, Quek, Marcus L., Gilliam-Hegarich, Susan, Kasahara, Nori, and Bochner, Bernard
Subjects
ADENOVIRUSES, BLADDER cancer, CANCER cells, CANCER treatment, GENE therapy, GENE expression, MEMBRANE proteins, COXSACKIEVIRUS diseases, COXSACKIEVIRUSES
Abstract
Objective: The insertion of absent or underexpressed genes into cancer cells to alter their malignant phenotype is an important potential application of available gene therapy technology. One of the more common viral vector systems that has been extensively studied for this purpose are the replication-deficient adenoviruses (Ad). Adenoviral infection of cells is mediated through a complex pathway, initiated following viral-cell attachment. Adenoviral-cell attachment occurs following interactions with a 46-kDa transmembrane protein with high affinity for both the Coxsackie and adenovirus, designated the CAR (Coxsackie and adenoviral receptor). [ABSTRACT FROM AUTHOR]