1. Hypertension in Cardiovascular and Kidney Disease: Recent Trends - Treating Two Diseases as One.
- Author
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De Pascalis A, Tomassetti A, Vetrano D, Tringali E, Di Lullo L, Napoli M, La Manna G, and Cianciolo G
- Subjects
- Humans, Antihypertensive Agents therapeutic use, Blood Pressure physiology, Glomerular Filtration Rate physiology, Risk Factors, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic physiopathology, Hypertension complications, Hypertension physiopathology, Hypertension drug therapy, Cardiovascular Diseases complications, Disease Progression
- Abstract
Background: Hypertension and chronic kidney disease (CKD) are closely interlinked pathophysiologic states, such that high blood pressure (BP) is an independent risk factor for disease progression in both adult and pediatric patients with kidney disorders and progressive decline in kidney function can conversely lead to worsening BP control., Summary: Hypertension in CKD is not only associated with GFR loss, but increases cardiovascular risk, which is the leading source of mortality and morbidity in this population. Given this complex relationship between hypertension, CKD, and CVD, an optimal management of BP in CKD is mandatory to break an established vicious pathophysiological cycle that leads to adverse outcomes., Key Messages: New promising molecules for the treatment of CKD, with interesting mechanisms, particularly regarding their pathophysiological interactions with arterial hypertension, are available or under development and in the very next future they may change the way we treat high BP in CKD patients., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2024
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