1. Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle
- Author
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Barbara J.M. Mulder, Karin van der Tuuk, Tjark Ebels, Willem Drenthen, Elke S. Hoendermis, Adriaan A. Voors, Jolien W. Roos-Hesselink, Sing C. Yap, Philip Moons, Hubert W. Vliegen, Dirk J. van Veldhuisen, Petronella G. Pieper, Arie P.J. van Dijk, Cardiovascular Centre (CVC), Cardiology, and ACS - Amsterdam Cardiovascular Sciences
- Subjects
Infertility ,Adult ,Male ,medicine.medical_specialty ,Heart disease ,media_common.quotation_subject ,Pregnancy Complications, Cardiovascular ,MEDLINE ,Fertility ,Double outlet right ventricle ,Prevalence ,Medicine ,Humans ,Pharmacology (medical) ,Registries ,Menstruation Disturbances ,media_common ,Retrospective Studies ,RISK ,Pregnancy ,COMPLICATIONS ,business.industry ,Obstetrics ,Infant, Newborn ,Pregnancy Outcome ,Retrospective cohort study ,medicine.disease ,congenital heart disease ,Double Outlet Right Ventricle ,Pregnancy Complications ,CONGENITAL HEART-DISEASE ,Female ,pregnancy ,Cardiology and Cardiovascular Medicine ,business ,Infertility, Female ,PROSPECTIVE MULTICENTER - Abstract
Objectives: To investigate outcome of pregnancy and fertility in women with double outlet right ventricle (DORV). Methods: Using 2 congenital heart disease registries, 21 female patients with DORV (aged 18–39 years) were retrospectively identified. Detailed recordings of each patient and their completed (>20 weeks gestation) pregnancies were recorded. Results: Overall, 10 patients had 19 pregnancies, including 3 spontaneous miscarriages (16%). During the 16 live birth pregnancies, primarily (serious) noncardiac complications were observed, e.g. premature labor/delivery (n = 7 and n = 3, respectively), small for gestational age (n = 4), preeclampsia (n = 2) and recurrence of congenital heart disease (n = 2). Except for postpartum endocarditis and deterioration of subpulmonary obstruction, only mild cardiac complication pregnancies were recorded. Two women with children reported secondary female infertility. Several menstrual cycle disorders were reported: secondary amenorrhea (n = 4), primary amenorrhea (n = 3) and oligomenorrhea (n = 2). Conclusion: Successful pregnancy in women with DORV is possible. Primarily noncardiac complications were observed and only few (minor) cardiac complications. Infertility and menstrual cycle disorders appear to be more prevalent.
- Published
- 2008