1. An aspiration material preparation system: application of a new liquid-based cytology technique for fine-needle aspiration of the breast.
- Author
-
Sakakibara E, Kimachi S, Hashimoto K, Inagaki H, Nagasaka T, Wakusawa S, and Yokoi T
- Subjects
- Biopsy, Fine-Needle instrumentation, Biopsy, Fine-Needle standards, Breast Neoplasms diagnosis, Breast Neoplasms surgery, Cytological Techniques instrumentation, Cytological Techniques standards, Female, Humans, Quality Control, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Biopsy, Fine-Needle methods, Breast cytology, Breast pathology, Breast Neoplasms pathology, Cytological Techniques methods
- Abstract
Objective: To evaluate the usefulness of our original liquid-based cell preparation system AMAPS (aspiration material preparation system) and to compare it with the AutoSmear system in breast aspiration cytology., Study Design: A total of 487 specimens of fine-needle aspiration cytology of the breast were retrieved, of which 250 were processed with AMAPS and 237 with the AutoSmear method (before the introduction of AMAPS). A final histological diagnosis was obtained by an excisional biopsy or a surgical resection in 148 cases., Results: Cell recovery rates were significantly improved with AMAPS (96.8 and 99.1% in Papanicolaou and Diff-Quik, respectively) compared with the AutoSmear method (40.9 and 42.3%, respectively; p<0.01). Within-run and day-to-day reproducibility of cell recovery was satisfactory, with coefficients of variations of 6.8 and 8.7%, respectively. Following the introduction of AMAPS in breast cytology, the unsatisfactory rate decreased significantly (from 16.0 to 8.8%; p<0.01), while the diagnostic sensitivity for malignancy did not change (97.8 to 98.1%). Moreover, the diagnostic specificity for benign lesions increased from 75 to 93.8%, thus decreasing the excision rate of fibrocystic disease., Conclusion: AMAPS may serve as an alternative to the conventional technique or commercially available liquid-based cytology systems., (Copyright © 2010 S. Karger AG, Basel.)
- Published
- 2011
- Full Text
- View/download PDF