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Aims: This study set out to test the hypothesis that the suicides that can be attributed to a psychiatric illness show a higher seasonality than the suicides due to any other reason., Methods: All the suicides registered in Italy from 1984 to 2000 (57,796 deaths by suicide: males = 41,741, yearly rate = 11.3 per 100,000; females = 16,055, yearly rate = 4.0 per 100,000) were analyzed with circular statistic techniques, based on the maximization of mean vector length method and on the Rayleigh test., Results: The suicides clearly attributed to a psychiatric illness were 35.0% among males and 51.3% among females. An economic reason for suicide was more frequently found among males; somatic illness or sentimental reasons were equally distributed in both sexes. The suicides attributable to a psychiatric illness showed a significantly higher seasonal unevenness than the suicides attributable to somatic illness and to sentimental or economic reasons., Conclusions: The main drawback of this study is that psychiatric diagnoses were not formally assessed by a forensic specialist. However, it succeeded in showing that the dynamics of suicidal behaviour are not unilineal: suicides due to psychiatric or somatic illness mainly happen in spring/summer and those due to economic difficulties mainly in December. Patients with psychiatric and/or somatic illness should be more carefully followed in spring/summer., (2007 S. Karger AG, Basel)

Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin C 6 mg/m(2) on day 1, and capecitabine (Xeloda) 2,000 mg/m(2)/day from day 1 to day 14 with cycles repeated every 4 weeks. Overall, 77.4% had visceral metastases and 33 were pretreated with >/=3 chemotherapy lines. A median of 6 cycles were given (range 1-19) with a complete response observed in 2 patients (3.9%), partial response in 17 (33.3%) and stable disease in 19 (37.2%). Overall response rate was 37.2% (95% CI, 24.0-50.5%), with a median duration of 10.4 months. Median time to progression was 8.1 months and median survival was 17.4 months (1- and 2-year survival rates of 60 and 28%, respectively). Toxicity was mild. The most frequent grade 3/4 events were neutropenia (5.7% of patients), diarrhea (3.8%), and deep venous thrombosis (3.8%). Capecitabine plus mitomycin C may represent an effective and manageable treatment option for advanced breast cancer patients resistant to anthracyclines and taxanes. This approach provides an alternative for pretreated patients with advanced breast cancer., (Copyright (c) 2006 S. Karger AG, Basel.)

Objective: To study time distribution of spontaneous deliveries., Methods: A retrospective analysis of 1,791 spontaneous deliveries over a 4-year period (1993-1996) was made at the department of Obstetrics and Gynaecology, Civil Hospital, Fano, Italy. Circular statistics techniques (maximization of mean vector length) were used., Results: Some unexpected infradian disuniformities (with 60- and 90-hour periods) were observed. Moreover, a correlation between the distribution of spontaneous deliveries and the lunar phases was found., Conclusions: In this study, some unexpected infradian disuniformities were found. However, no biological explanations appear to be reasonable in light of current knowledge, so the interpretation of these results remains an open question.