1. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity.
- Author
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Martínez-Abundis E, González-Ortiz M, Mercado-Sesma AR, Reynoso-von-Drateln C, and Moreno-Andrade A
- Subjects
- Adult, C-Reactive Protein metabolism, Double-Blind Method, Humans, Insulin Secretion, Interleukin-6 blood, Obesity blood, Obesity complications, Plant Extracts pharmacology, Statistics, Nonparametric, Insulin metabolism, Insulin Resistance, Obesity metabolism, Persea chemistry, Phytotherapy, Plant Extracts therapeutic use, Glycine max chemistry
- Abstract
Aim: To evaluate the effect of avocado soybean unsaponifiables (ASU) on insulin secretion and insulin sensitivity in patients with obesity., Methods: A randomized, double-blind, placebo-controlled, clinical trial was carried out in 14 obese adult volunteers. After random allocation of the intervention, 7 patients received 300 mg of ASU or placebo during a fasting state for 3 months. A metabolic profile including IL-6 and high-sensitivity C-reactive protein (hs-CRP) levels was carried out prior to the intervention. A hyperglycemic-hyperinsulinemic clamp technique was used to assess insulin secretion and insulin sensitivity phases. Mann-Whitney U test and Wilcoxon test were performed for statistical analyses. The study was approved by the local ethics committee of our institution., Results: At baseline, both groups were similar according to clinical and laboratory characteristics. There was no significant difference in insulin secretion and insulin sensitivity with ASU., Conclusions: ASU administration for 3 months did not modify insulin secretion and insulin sensitivity in patients with obesity., (© 2013 S. Karger GmbH, Freiburg.)
- Published
- 2013
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