8 results on '"Premi E"'
Search Results
2. Revisiting brain reserve hypothesis in frontotemporal dementia: evidence from a brain perfusion study
- Author
-
Enrico Premi, Raffaele Giubbini, Alessandro Padovani, Giuseppe Bellelli, Daniela Perani, Barbara Borroni, Antonella Alberici, Valentina Garibotto, Silvia Lucchini, Barbara Paghera, Chiara Agosti, Borroni, B, Premi, E, Agosti, C, Alberici, A, Garibotto, V, Bellelli, G, Paghera, B, Lucchini, S, Giubbini, R, Perani, D, Padovani, A, Perani, DANIELA FELICITA L., and Padovani, A.
- Subjects
Male ,Aging ,Cognitive Neuroscience ,Perfusion scanning ,Neuropsychological Tests ,Brain mapping ,Education ,Leisure Activities ,brain reserve ,Degenerative disease ,medicine ,Image Processing, Computer-Assisted ,Humans ,Dementia ,Cysteine ,Occupations ,Radionuclide Imaging ,Organotechnetium Compound ,Cognitive reserve ,Aged ,Brain Mapping ,Behavior ,Occupation ,neuroimaging ,Cognitive disorder ,Brain ,Frontotemporal lobe degeneration ,SPECT ,Organotechnetium Compounds ,Frontotemporal lobar degeneration ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Cerebrovascular Circulation ,Leisure Activitie ,Radiopharmaceutical ,Neuropsychological Test ,Female ,Radiopharmaceuticals ,Geriatrics and Gerontology ,Psychology ,Neuroscience ,Frontotemporal dementia ,Human - Abstract
Background: Literature data on Alzheimer’s disease suggest that years of schooling and occupational level are associated with a reserve mechanism. No data on patients with behavioral variant frontotemporal dementia (bvFTD) are available yet. Objective: To evaluate the impact of education, occupation, and midlife leisure activities on brain reserve in bvFTD. Methods: Fifty-four bvFTD patients entered the study and underwent neuropsychological and behavioral assessment, including the FTD-modified Clinical Dementia Rating for FTD (FTD-modified CDR), and SPECT imaging. We tested for the linear correlation of educational and occupational level, and midlife leisure activities with regional cerebral blood flow (rCBF), controlling for demographic variables (age and gender) and for cognitive performance (FTD-modified CDR) (statistical parametric mapping). Results: A significant relationship between higher educational and occupational attainments and lower rCBF in medial frontal cortex and dorsolateral frontal cortex, bilaterally, was found (p < 0.005). When midlife leisure activities were considered, no correlation was found. The correlation between a reserve index, accounting for both educational and occupational level, and rCBF showed the same pattern of hypoperfusion. Conclusions: This study suggests that education and occupation act as proxies for reserve capacity in bvFTD. These lifestyle attainments may counteract the onset of this genetic-based disease in at-risk individuals.
- Published
- 2009
3. Clinical and Diagnostic Findings of Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy in the COVID-19 Era.
- Author
-
Premi E, Acampora R, Salmi D, Ilie I, Pagnoncelli N, Germano F, Gandolfi G, Sanicas M, Seed A, Michael B, Donati S, Azzolini C, and Lanfranchi F
- Subjects
- Humans, SARS-CoV-2, Retina, COVID-19 Testing, COVID-19, White Dot Syndromes, Retinal Diseases diagnosis, Macular Degeneration
- Abstract
Background: Growing evidence suggests an association between the infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and eye disorders. The aim of this review was to analyze the clinical presentation and diagnostic features of acute macular neuroretinopathy (AMN) and paracentral acute middle maculopathy (PAMM) associated with COVID-19 infection. The features are then compared with previous reports regarding these retinal disorders, to recognize possible specific characteristics and to assess the role of multimodal ophthalmic imaging., Summary: A literature search was performed by consulting PubMed, Scopus, and Embase. The following terms were searched: "(COVID-19 OR SARS-CoV-2 OR coronavirus) AND ([acute macular neuroretinopathy] OR [paracentral acute middle maculopathy])." Inclusion criteria were as follows: (1) publication date from January 31, 2020 to January 31, 2022; (2) English language; (3) original research or case report; (4) free full-text availability.Optical coherence tomography (OCT) findings in AMN patients were hyper-reflectivity (HR) of the outer plexiform layer, of the outer nuclear layer, and ellipsoid or interdigitation zones (EZ and IZ, respectively) disruption. In most cases, the presence of HR and EZ/IZ abnormalities resulted combined. When performed, OCT angiography (OCTA) identified attenuation of signal of the deep capillary plexus (DCP). The most common OCT finding in PAMM was an alteration of the inner nuclear layer, associated with other areas of HR, while no signs of EZ/IZ disruption were detected. When performed, OCTA showed the attenuation of signal of both the DCP and the superficial capillary plexus., Key Messages: In this review, we reported a case series of AMN and PAMM in patients with a previous or concomitant infection from SARS-CoV-2. The microvascular changes in these cases are highlighted by the OCTA scans. Even if we are far from the determination of a direct link between COVID-19 and these retinal disorders, we could hypothesize that the vascular alterations associated with SARS-CoV-2 infection could be a possible risk factor for both AMN and PAMM., (© 2023 S. Karger AG, Basel.)
- Published
- 2023
- Full Text
- View/download PDF
4. Multimodal Brain Analysis of Functional Neurological Disorders: A Functional Stroke Mimic Case Series.
- Author
-
Premi E, Benussi A, Compostella S, Gilberti N, Vergani V, Delrio I, Spezi R, Gamba M, Costa A, Gasparotti R, Magoni M, Padovani A, and Borroni B
- Subjects
- Adult, Female, Humans, Multimodal Imaging, Stress, Psychological psychology, Diagnosis, Differential, Nervous System Diseases diagnosis, Stroke diagnosis, Stroke drug therapy, Tissue Plasminogen Activator therapeutic use
- Published
- 2017
- Full Text
- View/download PDF
5. Iron in Frontotemporal Lobar Degeneration: A New Subcortical Pathological Pathway?
- Author
-
Gazzina S, Premi E, Zanella I, Biasiotto G, Archetti S, Cosseddu M, Scarpini E, Galimberti D, Serpente M, Gasparotti R, Padovani A, and Borroni B
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease genetics, Atrophy, Brain pathology, Cohort Studies, Female, Frontotemporal Lobar Degeneration genetics, Frontotemporal Lobar Degeneration psychology, Gene Frequency, Gray Matter diagnostic imaging, Gray Matter metabolism, Gray Matter pathology, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Organ Size, Pilot Projects, Polymorphism, Genetic, Brain diagnostic imaging, Brain metabolism, Frontotemporal Lobar Degeneration diagnostic imaging, Frontotemporal Lobar Degeneration metabolism, Hemochromatosis Protein genetics, Iron metabolism
- Abstract
Introduction: Brain iron homeostasis dysregulation has been widely related to neurodegeneration. In particular, human haemochromatosis protein (HFE) is involved in iron metabolism, and HFE H63D polymorphism has been related to the risk of amyotrophic lateral sclerosis and Alzheimer's disease. Recently, iron accumulation in the basal ganglia of frontotemporal lobar degeneration (FTLD) patients has been described., Objective: To explore the relationship between HFE genetic variation and demographic, clinical and imaging characteristics in a large cohort of FTLD patients., Methods: A total of 110 FTLD patients underwent neuropsychological and imaging evaluation and blood sampling for HFE polymorphism determination. HFE H63D polymorphism was considered in the present study. Two imaging approaches were applied to evaluate the effect of HFE genetic variation on brain atrophy, namely voxel-based morphometry and region of interest-based probabilistic approach (SPM8; Wellcome Trust Centre for Neuroimaging)., Results: FTLD patients carrying the D* genotype (H/D or D/D) showed greater atrophy in the basal ganglia, bilaterally, compared to H/H carriers (x, y, z: -22, -4, 0; T = 3.45; cluster size: 33 voxels, x, y, z: 24, 4, -2; T = 3.38; cluster size: 36 voxels). The former group had even more pronounced behavioural symptoms, as defined by the Frontal Behavioural Inventory total scores., Conclusions: Our data suggest that H63D polymorphism could represent a disease-modifying gene in FTLD, fostering iron deposition in the basal ganglia. This suggests a new possible mechanism of FTLD-associated neurodegeneration., (© 2015 S. Karger AG, Basel.)
- Published
- 2016
- Full Text
- View/download PDF
6. Subcortical and Deep Cortical Atrophy in Frontotemporal Dementia due to Granulin Mutations.
- Author
-
Premi E, Garibotto V, Gazzina S, Formenti A, Archetti S, Gasparotti R, Padovani A, and Borroni B
- Abstract
Background/aims: Parkinsonism is often associated with symptoms of frontotemporal dementia (FTD), but its pathogenesis has been largely neglected. In genetic inherited FTD-related granulin (GRN) mutations, parkinsonism is an early sign, and it is more common than in sporadic disorders. Our aim was to study grey matter (GM) volume changes in subcortical and deep cortical regions in GRN-related FTD., Methods: A total of 33 FTD patients (13 carriers of the GRN mutation, GRN+, and 20 non-carriers, GRN-) and 12 healthy controls (HC) were included in the study. Each subject underwent an MRI examination (1) for voxel-based morphometry to study GM differences in cortical and subcortical regions, and (2) for a region of interest approach using a probabilistic atlas of subcortical regions (caudate nucleus, putamen, thalamus and amygdala) to assess the regional differences., Results: The GRN+ group showed greater damage in frontotemporal regions than the GRN- group. The FTD patients had greater GM atrophy in the caudate nucleus and in the thalamus bilaterally than the HC. Damage to these subcortical and deep cortical regions was greater in the GRN+ than in the GRN- patients., Discussion: Subcortical and deep cortical involvement is a key feature of FTD, and more pronounced in GRN-related disease. Damage to the caudate region in GRN+ patients may explain the parkinsonism frequently associated since the early stages of the disease.
- Published
- 2014
- Full Text
- View/download PDF
7. Nature versus nurture in frontotemporal lobar degeneration: the interaction of genetic background and education on brain damage.
- Author
-
Premi E, Garibotto V, Alberici A, Paghera B, Giubbini R, Padovani A, and Borroni B
- Subjects
- Aged, Cohort Studies, Educational Status, Female, Frontal Lobe blood supply, Frontotemporal Lobar Degeneration psychology, Gene-Environment Interaction, Genetic Predisposition to Disease, Gyrus Cinguli blood supply, Humans, Intercellular Signaling Peptides and Proteins genetics, Male, Parietal Lobe blood supply, Progranulins, Regional Blood Flow genetics, Temporal Lobe blood supply, Tomography, Emission-Computed, Single-Photon, tau Proteins genetics, Brain blood supply, Cognitive Reserve, Frontotemporal Lobar Degeneration genetics
- Abstract
Background: Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder with a strong genetic background. It has been reported that modifiable factors, i.e. education (E), might act as proxies for reserve capacity., Objective: To evaluate the impact of genetic background (positive family history, FH) on reserve mechanisms, by measuring regional cerebral blood flow (rCBF) correlates in FTLD patients., Methods: 145 FTLD patients were recruited and underwent clinical, neuropsychological, behavioral assessment, and SPECT study. The main effect of E and FH on rCBF was evaluated. To test the potential interaction between the E and rCBF in FTLD patients with or without positive FH, a difference of slope analysis in the two groups was calculated. All the analyses were controlled for disease severity (Clinical Dementia Rating Scale, FTD-CDR)., Results: A main effect of education (E+ < E-) in frontal regions was reported, and high genetic loading (FH+ < FH-) was associated with a greater bilateral temporoparietal hypoperfusion. Evaluating the relationship between E and rCBF, a greater hypoperfusion of cingulate region in FH+ as compared to FH- was observed., Discussion: Reserve mechanisms are available also in presence of an unfavorable genetic status. However, these compensatory mechanisms are modulated by the interaction with genetic factors., (Copyright © 2012 S. Karger AG, Basel.)
- Published
- 2012
- Full Text
- View/download PDF
8. Revisiting brain reserve hypothesis in frontotemporal dementia: evidence from a brain perfusion study.
- Author
-
Borroni B, Premi E, Agosti C, Alberici A, Garibotto V, Bellelli G, Paghera B, Lucchini S, Giubbini R, Perani D, and Padovani A
- Subjects
- Aged, Aging physiology, Behavior physiology, Brain Mapping, Cysteine analogs & derivatives, Dementia diagnostic imaging, Education, Female, Humans, Image Processing, Computer-Assisted, Leisure Activities, Male, Middle Aged, Neuropsychological Tests, Occupations, Organotechnetium Compounds, Radionuclide Imaging, Radiopharmaceuticals, Brain diagnostic imaging, Brain physiology, Cerebrovascular Circulation physiology, Dementia physiopathology
- Abstract
Background: Literature data on Alzheimer's disease suggest that years of schooling and occupational level are associated with a reserve mechanism. No data on patients with behavioral variant frontotemporal dementia (bvFTD) are available yet., Objective: To evaluate the impact of education, occupation, and midlife leisure activities on brain reserve in bvFTD., Methods: Fifty-four bvFTD patients entered the study and underwent neuropsychological and behavioral assessment, including the FTD-modified Clinical Dementia Rating for FTD (FTD-modified CDR), and SPECT imaging. We tested for the linear correlation of educational and occupational level, and midlife leisure activities with regional cerebral blood flow (rCBF), controlling for demographic variables (age and gender) and for cognitive performance (FTD-modified CDR) (statistical parametric mapping)., Results: A significant relationship between higher educational and occupational attainments and lower rCBF in medial frontal cortex and dorsolateral frontal cortex, bilaterally, was found (p < 0.005). When midlife leisure activities were considered, no correlation was found. The correlation between a reserve index, accounting for both educational and occupational level, and rCBF showed the same pattern of hypoperfusion., Conclusions: This study suggests that education and occupation act as proxies for reserve capacity in bvFTD. These lifestyle attainments may counteract the onset of this genetic-based disease in at-risk individuals.
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.