1. Immunosuppression in experimental Junin virus infection of mice.
- Author
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Giovanniello OA, Nejamkis MR, Galassi NV, and Nota NR
- Subjects
- Age Factors, Animals, Antilymphocyte Serum pharmacology, Arenaviruses, New World, Cyclophosphamide pharmacology, Cytarabine pharmacology, Dose-Response Relationship, Drug, Mice, Mice, Inbred BALB C, Pyridines pharmacology, T-Lymphocytes immunology, Hemorrhagic Fever, American immunology, Immunosuppression Therapy
- Abstract
The effects of cyclophosphamide (CY), anti-mouse thymocyte sera, oxisuran, and cytosine arabinoside were evaluated in adult and newborn mice infected with Junin virus. Treatment with CY was the most effective, Adult mice, which are not normally susceptible to intracerebral infection with 10(3) LD50 of Junin virus, were rendered susceptible by treatment with an adequate dose and schedule of CY. However, CY-treated newborn mice were protected from death. This animal model may be suitable for use in pathogenesis and protection studies.
- Published
- 1980
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