1. Iron status and analysis of efficacy and safety of ferric carboxymaltose treatment in patients with inflammatory bowel disease.
- Author
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Beigel F, Löhr B, Laubender RP, Tillack C, Schnitzler F, Breiteneicher S, Weidinger M, Göke B, Seiderer J, Ochsenkühn T, and Brand S
- Subjects
- Adolescent, Adult, Aged, Anemia, Iron-Deficiency blood, Cohort Studies, Female, Ferric Compounds administration & dosage, Ferric Compounds adverse effects, Ferric Compounds blood, Ferritins blood, Hemoglobins, Humans, Inflammatory Bowel Diseases blood, Infusions, Intravenous, Iron blood, Male, Maltose administration & dosage, Maltose adverse effects, Maltose blood, Maltose therapeutic use, Middle Aged, Treatment Outcome, Young Adult, Anemia, Iron-Deficiency drug therapy, Ferric Compounds therapeutic use, Inflammatory Bowel Diseases drug therapy, Maltose analogs & derivatives
- Abstract
Background and Aims: We analyzed iron deficiency and the therapeutic response following intravenous ferric carboxymaltose in a large single-center inflammatory bowel disease (IBD) cohort., Methods: 250 IBD patients were retrospectively analyzed for iron deficiency and iron deficiency anemia. A subgroup was analyzed regarding efficacy and side effects of iron supplementation with ferric carboxymaltose., Results: In the cohort (n = 250), 54.4% of the patients had serum iron levels ≤60 μg/dl, 81.2% had ferritin ≤100 ng/ml, and 25.6% had hemoglobin (Hb) of ≤12 g/dl (females) or ≤13 g/dl (males). In the treatment subcohort (n = 80), 83.1% of the patients had iron ≤60 μg/dl, 90.4% had ferritin ≤100 ng/ml, and 66.7% had Hb ≤12/13 g/dl before ferric carboxymaltose treatment. After a median dose of 500 mg ferric carboxymaltose, 74.7% of the patients reached iron >60 μg/dl, 61.6% had ferritin >100 ng/ml, and 90.7% reached Hb >12/13 g/dl at follow-up (p < 0.0001 for all parameters vs. pretreatment values). The most frequent adverse event was a transient increase of liver enzymes with male gender as risk factor (p = 0.008, OR 8.62, 95% CI 1.74-41.66)., Conclusions: Iron deficiency and anemia are frequent in IBD patients. Treatment with ferric carboxymaltose is efficious, safe and well tolerated in iron-deficient IBD patients., (Copyright © 2011 S. Karger AG, Basel.)
- Published
- 2012
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