1. Renal involvement in psychological eating disorders
- Author
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Giuseppe Mulè, Gioacchino Li Cavoli, U Rotolo, Li Cavoli, G, Mule', G, and Rotolo, U.
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Anorexia Nervosa ,Hypokalemia ,Bioinformatics ,Rhabdomyolysis ,Adipokines ,Binge-eating disorder ,Internal medicine ,Animals ,Humans ,Medicine ,Obesity ,Bulimia ,Inflammation ,Dehydration ,Glomerulosclerosis, Focal Segmental ,business.industry ,Bulimia nervosa ,Bulimia Nervosa ,Acute kidney injury ,General Medicine ,Kidney disease ,medicine.disease ,Kidney diseases ,Nephrocalcinosis ,Eating disorders ,Endocrinology ,Anorexia nervosa (differential diagnoses) ,Cytokines ,Intercellular Signaling Peptides and Proteins ,Female ,Kidney Diseases ,business - Abstract
Psychological eating disorders – anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder – are an increasing public health problem with severe clinical manifestations: hypothermia, hypotension, electrolyte imbalance, endocrine disorders and kidney failure; they are of interest to nephrologists, but pathophysiological mechanisms in determining the renal involvement are still unclear. We describe pathophysiology, histological features and clinical manifestations of the most frequent psychological eating disorders: AN and BN. Regarding AN, we analyze the recent literature, and identify 3 principal pathways towards renal involvement: chronic dehydration-hypokalemia, nephrocalcinosis and chronic rhabdomyolysis. Regarding BN, we describe the correlation between obesity and many proinflammatory cytokines, chemokines, growth factors and adipokines, having potential metabolic and hemodynamic effects on the kidney and an important role in the pathogenesis of obesity-related renal injury, independently of hypertension and diabetes.
- Published
- 2011