1. Failure to Replicate Influence of GRIK4 and GNB3 Polymorphisms on Treatment Outcome in Major Depression
- Author
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Joseph Zohar, Alessandro Serretti, Julien Mendlewicz, Carlos Forray, M. Fink, Sylvie Linotte, Raffaella Calati, Lenore Snyder, Irina Antonijevic, Siegfried Kasper, Diana De Ronchi, Ursula F. Bailer, Concetta Crisafulli, Isabelle Massat, Yves Lecrubier, Alberto Chiesa, Joseph Bollen, Daniel Souery, Serretti, A, Chiesa, A, Crisafulli, C, Massat, I, Linotte, S, Calati, R, Kasper, S, Bailer, U, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A., Chiesa A., Crisafulli C., Massat I., Linotte S., Calati R., Kasper S., Bailer U., Lecrubier Y., Fink M., Antonijevic I., Forray C., Snyder L., Bollen J., Zohar J., De Ronchi D., Souery D., and Mendlewicz J.
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Candidate gene ,Genotype ,Treatment outcome ,GNB3 ,GRIK4 ,Gene Frequency ,Receptors, Kainic Acid ,Internal medicine ,medicine ,Humans ,Genetic Association Studies ,Biological Psychiatry ,Depression (differential diagnoses) ,Aged ,Genetic association ,MAJOR DEPRESSIVE DISORDER ,Depressive Disorder, Major ,Polymorphism, Genetic ,biology ,Replicate ,Middle Aged ,medicine.disease ,Heterotrimeric GTP-Binding Proteins ,Antidepressive Agents ,Psychiatry and Mental health ,Treatment Outcome ,Neuropsychology and Physiological Psychology ,Major depressive disorder, GRIK4, GNB3 ,biology.protein ,Regression Analysis ,Major depressive disorder ,Female ,Psychology ,Clinical psychology - Abstract
In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies.
- Published
- 2012